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Q5P229

- GCH4_AROAE

UniProt

Q5P229 - GCH4_AROAE

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, AZOSEA25100, ebA4438
Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciAARO76114:GJTA-2541-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:AZOSEA25100
ORF Names:ebA4438
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147698Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA4438.

Structurei

3D structure databases

ProteinModelPortaliQ5P229.
SMRiQ5P229. Positions 21-265.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5P229-1 [UniParc]FASTAAdd to Basket

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MTSQQAHAIP DVQNLNDSRK LAIDKVGIKS IRHPVRVSDK NGGVQHTIAV    50
FNMYVGLPHN FKGTHMSRFI EIINGNEREI SVESIEPMLR EMVKRLEAET 100
GQIELTFPYF INKSAPISGV QSLMDYEVTF TAEIREGGAY TFTMKTVVPV 150
TSLCPCSKKI SEYGAHNQRS HVTVTAQTNS FLWIEELVQL VESQASCQLY 200
GLLKRPDEKY VTEHAYDNPK FVEDMVRDVA GLLNAEARID CYRVESENFE 250
SIHNHSAYAL IECDKRLVVG AN 272
Length:272
Mass (Da):30,684
Last modified:April 12, 2005 - v2
Checksum:iD30AA5127945236A
GO

Sequence cautioni

The sequence CAI08635.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI08635.1. Different initiation.
RefSeqiYP_159536.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI08635; CAI08635; ebA4438.
GeneIDi3179527.
KEGGieba:ebA4438.
PATRICi20971206. VBIAroAro98752_2541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI08635.1 . Different initiation.
RefSeqi YP_159536.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5P229.
SMRi Q5P229. Positions 21-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76114.ebA4438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI08635 ; CAI08635 ; ebA4438 .
GeneIDi 3179527.
KEGGi eba:ebA4438.
PATRICi 20971206. VBIAroAro98752_2541.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci AARO76114:GJTA-2541-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiGCH4_AROAE
AccessioniPrimary (citable) accession number: Q5P229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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