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Q5P229 (GCH4_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:AZOSEA25100
ORF Names:ebA4438
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence CAI08635.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147698

Sites

Site1541May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5P229 [UniParc].

Last modified April 12, 2005. Version 2.
Checksum: D30AA5127945236A

FASTA27230,684
        10         20         30         40         50         60 
MTSQQAHAIP DVQNLNDSRK LAIDKVGIKS IRHPVRVSDK NGGVQHTIAV FNMYVGLPHN 

        70         80         90        100        110        120 
FKGTHMSRFI EIINGNEREI SVESIEPMLR EMVKRLEAET GQIELTFPYF INKSAPISGV 

       130        140        150        160        170        180 
QSLMDYEVTF TAEIREGGAY TFTMKTVVPV TSLCPCSKKI SEYGAHNQRS HVTVTAQTNS 

       190        200        210        220        230        240 
FLWIEELVQL VESQASCQLY GLLKRPDEKY VTEHAYDNPK FVEDMVRDVA GLLNAEARID 

       250        260        270 
CYRVESENFE SIHNHSAYAL IECDKRLVVG AN 

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR555306 Genomic DNA. Translation: CAI08635.1. Different initiation.
RefSeqYP_159536.1. NC_006513.1.

3D structure databases

ProteinModelPortalQ5P229.
SMRQ5P229. Positions 21-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING76114.ebA4438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI08635; CAI08635; ebA4438.
GeneID3179527.
KEGGeba:ebA4438.
PATRIC20971206. VBIAroAro98752_2541.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycAARO76114:GJTA-2541-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_AROAE
AccessionPrimary (citable) accession number: Q5P229
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways