Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5P1H1 (HEMH_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:AZOSEA27180
ORF Names:ebA4802
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Ferrochelatase HAMAP MF_00323
PRO_1000079191

Sites

Metal binding2111Iron By similarity
Metal binding2921Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5P1H1 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: CCA823B06B001676

FASTA36540,386
        10         20         30         40         50         60 
MARYWPEPAH THGTPERTGI LLVNLGTPAA PTAAAVRPYL KEFLSDPRVV EIPRAIWWPI 

        70         80         90        100        110        120 
LNGVILNLRP KKSAEKYAAI WSDAGSPLKV HTERQAKLLA GYLGHAGVTS VVVDWAMRYG 

       130        140        150        160        170        180 
APSISDILGR MKAEGCSRIL VVPLYPQYAA STTASVIDEV AGCLTRWRNL PEIRYVRNFH 

       190        200        210        220        230        240 
DHPGYVGALA RSVRDHWAKH GEPDQLVMSF HGIPKRSLDL GDPYHCECHV TARLLAAKLD 

       250        260        270        280        290        300 
LPPERWQLTF QSRFGKAEWL KPYTQPTLEA LGRKGTGRVD VICPGFASDC LETLEEIALE 

       310        320        330        340        350        360 
CRTAFLGAGG KAFHYIPCLN ERHDWIAALT DIVRSRIGDW LEAPVPAAEL LAATAQRART 


AGAER

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR555306 Genomic DNA. Translation: CAI08843.1.
RefSeqYP_159744.1. NC_006513.1.

3D structure databases

ProteinModelPortalQ5P1H1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5P1H1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3179668.
GenomeReviewsGene locus AZOSEA27180 in contig CR555306_GR.
KEGGeba:ebA4802.
NMPDRfig|76114.4.peg.2615.
PATRIC20971630. VBIAroAro98752_2745.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycASP76114:EBA4802-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_AROAE
AccessionPrimary (citable) accession number: Q5P1H1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents