Reviewed, UniProtKB/Swiss-Prot Q5P1G6 (DAPB_AZOSE)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	AZOSEA27230
ORF Names:	ebA4812

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228320

Sequences

	Sequence		Length	Mass (Da)
	Q5P1G6-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: F2138D20D2FFF1B4	FASTA	276	28,962
	10 20 30 40 50 60 MSSKRNSLML PLRIAIAGAS GRMGRMLIEA TLKEEGAVLA SAFDRPGTTF IGRDAGELSG 70 80 90 100 110 120 SATGILITDD PRAAIAAADC VIDFTRPEGT LAHLALAREL GKAMVIGTTG FSTAEKEAIA 130 140 150 160 170 180 AAAQAIPIVF APNMAVGVNA VFKLLEVAAR ILDDGYDVEV IEAHHRFKVD APSGTALRMG 190 200 210 220 230 240 EVVACELGRD LETCAIYGRE GVTGERKAET IGFSTIRGGD VVGDHTVLFA GIGERIEITH 250 260 270 RSGSRMPYAS GSLRAARFLA GRSSGLFDMQ DVLGLR

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR555306 Genomic DNA. Translation: CAI08848.1.
RefSeq	YP_159749.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3180017.
GenomeReviews	Gene locus AZOSEA27230 in contig CR555306_GR.
KEGG	eba:ebA4812.
NMPDR	fig|76114.4.peg.2620.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5P1G6.
OMA	Q5P1G6. TIGFSTI.
Enzyme and pathway databases
BioCyc	ASP76114:EBA4812-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_AZOSE

Accession

Primary (citable) accession number: Q5P1G6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	January 4, 2005
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)