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Q5P0Z8 (OTC_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3
Gene names
Name:argF
Ordered Locus Names:AZOSEA28910
ORF Names:ebA5096
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109

Subcellular location

Cytoplasm By similarity HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Ornithine carbamoyltransferase HAMAP MF_01109
PRO_1000084835

Regions

Region54 – 585Carbamoyl phosphate binding By similarity
Region260 – 2634Ornithine binding By similarity

Sites

Binding site1051Carbamoyl phosphate By similarity
Binding site1321Carbamoyl phosphate By similarity
Site291Important for structural integrity By similarity
Site1451Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5P0Z8 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: C4F19D6F0C66CBC9

FASTA30735,190
        10         20         30         40         50         60 
MTKPRHYLQF KDFTRDDYRH VFDRTRWIKD KFKRYEPYHP LFDRTLVMIF EKASTRTRLS 

        70         80         90        100        110        120 
FEAGMQQLGG SAIYLNTRDS QLGRGEPVED AAQVISRMSD VVMIRTFEQD IIERFAAHSR 

       130        140        150        160        170        180 
VPVINGLTNE YHPCQILADI YTFIEHRGSI QGRTVAWVGD SNNMCNTWLQ AAELLDFNVH 

       190        200        210        220        230        240 
VSTPPGYEVE PERAGLYGTG HFEQFADPME ACKGADLVTT DVWTSMGFEA ENDERMKDFA 

       250        260        270        280        290        300 
DWCVDAEMMA AARADAVFMH CLPAHRGEEV TADVIDGAQS VVWDEAENRL HVQKALMEYL 


VLGKVED

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR555306 Genomic DNA. Translation: CAI09016.1.
RefSeqYP_159917.1. NC_006513.1.

3D structure databases

HSSPHSSP built from PDB template 1VLV based on UniProtKB P96108.
ProteinModelPortalQ5P0Z8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5P0Z8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3181152.
GenomeReviewsGene locus AZOSEA28910 in contig CR555306_GR.
KEGGeba:ebA5096.
NMPDRfig|76114.4.peg.2913.
PATRIC20971986. VBIAroAro98752_2921.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0078.
HOGENOMHBG579429.
OMASHDKFEA.
ProtClustDBPRK00779.

Enzyme and pathway databases

BioCycASP76114:EBA5096-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTC_AROAE
AccessionPrimary (citable) accession number: Q5P0Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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