Q5P0T4 (G6PI_AROAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	AZOSEA29550
ORF Names:	ebA5208

Organism

Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.
Sequence caution	The sequence CAI09080.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 545	545	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180583
Sites
	Active site	353	1	Proton donor By similarity
	Active site	384	1	By similarity
	Active site	510	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5P0T4 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: 4522A66F760D3B34	FASTA	545	57,836
	10 20 30 40 50 60 MTEPFTPPHR LSAWSTLENH AARLRTMRIA ELFEHDAARF ATLSFGHRGL LLDLSKQSID 70 80 90 100 110 120 APALAALVDL AGQARLPDGI EALFAGEHLN FTEDRAVLHM ALRGACAAPL EDAATLAQSQ 130 140 150 160 170 180 QRMRAFTVAL RSGTMTGATG KPIRLVVNLG IGGSDLGPRM AAQALVPTGL RATPEVRFVA 190 200 210 220 230 240 NIDRRELDEA LADADPASTL FVVSSKSFAT AETLANAQAA RAWLQAGLGA GCDPALHFTA 250 260 270 280 290 300 VSNATDAAAA FGIPAERVFP LPEWVGGRYS VWSTIGLPLM IAIGASEFDA FLAGARAMDE 310 320 330 340 350 360 HFRTAPPGEN LPVLMGLAGL WNTDFLGIES LALLPYAHGL RSFAAWLQQL EMESNGKRCL 370 380 390 400 410 420 RDGSGSVIHT SPIVWGGVGT VGQHAFHQLF YQGTRRVALD FIVPVAAADD VSQRSLVENA 430 440 450 460 470 480 FAQSAALMSG RDLDTALASL RAKGLAESEA AVLAPHLVCP GNQPSTTVLL PALDAFSLGQ 490 500 510 520 530 540 LMALYEHKVF VQGWIWGINS FDQYGVELGK EMARSLSAGS GENHDASTAG LMAAAEAMRR TPDRS

References

[1]

"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EbN1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR555306 Genomic DNA. Translation: CAI09080.1. Different initiation.
RefSeq	YP_159981.1. NC_006513.1.
3D structure databases
ProteinModelPortal	Q5P0T4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5P0T4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3181003.
GenomeReviews	Gene locus AZOSEA29550 in contig CR555306_GR.
KEGG	eba:ebA5208.
NMPDR	fig|76114.4.peg.2957.
PATRIC	20972118. VBIAroAro98752_2987.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
OMA	WIWGINS.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	ASP76114:EBA5208-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_AROAE

Accession

Primary (citable) accession number: Q5P0T4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program