Q5NZG2 (LPXB_AROAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	AZOSEA34270
ORF Names:	ebA6002

Organism

Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum › Aromatoleum aromaticum

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255160

Sequences

	Sequence		Length	Mass (Da)
	Q5NZG2 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: A6607CA2A0110B54	FASTA	391	43,120
	10 20 30 40 50 60 MATRIAMVAG EASGDLLASH LIRAIRQQVP EAEFYGIGGP KMQAEGFDAL WPCERLAVHG 70 80 90 100 110 120 YVDALKRYRE LSGIRKALLR RVQADRPDAF IGVDAPDFNL WLEGRIRSSG IPAIHFVSPS 130 140 150 160 170 180 IWAWRGGRIK GIARSVSHML CLFPFEPALY EKAGIPVSYV GHPLADVFPL VPDRAAAREL 190 200 210 220 230 240 LSLPTDCRIV ALLPGSRQSE VRSLAATYIE TARLLAERHP DIGFVVPLAT RETRALFEQA 250 260 270 280 290 300 LHAADADELP IRLLFGHAVE AMTAADVVLV ASGTASLEAA LLKRPMVISY RIGKWQYRLM 310 320 330 340 350 360 KRMAYLPWVG LPNILCNDSV VPELLQDDAT PQALADALDR WLNDADACAE LALRFDALHR 370 380 390 ELRQDTAGRA AAAILPYLNR SPEWKPSRQS A

References

[1]

"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EbN1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR555306 Genomic DNA. Translation: CAI09552.1.
RefSeq	YP_160453.1. NC_006513.1.
3D structure databases
ProteinModelPortal	Q5NZG2.
ModBase	Search...
Protein-protein interaction databases
STRING	76114.ebA6002.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI09552; CAI09552; ebA6002.
GeneID	3181086.
KEGG	eba:ebA6002.
PATRIC	20973075. VBIAroAro98752_3455.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018003.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	CLSK767007.
Enzyme and pathway databases
BioCyc	AARO76114:GJTA-3479-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_AROAE

Accession

Primary (citable) accession number: Q5NZG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program