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Q5NZG2

- LPXB_AROAE

UniProt

Q5NZG2 - LPXB_AROAE

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, AZOSEA34270, ebA6002
Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAARO76114:GJTA-3479-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:AZOSEA34270
ORF Names:ebA6002
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255160Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA6002.

Structurei

3D structure databases

ProteinModelPortaliQ5NZG2.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NZG2-1 [UniParc]FASTAAdd to Basket

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MATRIAMVAG EASGDLLASH LIRAIRQQVP EAEFYGIGGP KMQAEGFDAL    50
WPCERLAVHG YVDALKRYRE LSGIRKALLR RVQADRPDAF IGVDAPDFNL 100
WLEGRIRSSG IPAIHFVSPS IWAWRGGRIK GIARSVSHML CLFPFEPALY 150
EKAGIPVSYV GHPLADVFPL VPDRAAAREL LSLPTDCRIV ALLPGSRQSE 200
VRSLAATYIE TARLLAERHP DIGFVVPLAT RETRALFEQA LHAADADELP 250
IRLLFGHAVE AMTAADVVLV ASGTASLEAA LLKRPMVISY RIGKWQYRLM 300
KRMAYLPWVG LPNILCNDSV VPELLQDDAT PQALADALDR WLNDADACAE 350
LALRFDALHR ELRQDTAGRA AAAILPYLNR SPEWKPSRQS A 391
Length:391
Mass (Da):43,120
Last modified:January 4, 2005 - v1
Checksum:iA6607CA2A0110B54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI09552.1.
RefSeqiYP_160453.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI09552; CAI09552; ebA6002.
GeneIDi3181086.
KEGGieba:ebA6002.
PATRICi20973075. VBIAroAro98752_3455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI09552.1 .
RefSeqi YP_160453.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5NZG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76114.ebA6002.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI09552 ; CAI09552 ; ebA6002 .
GeneIDi 3181086.
KEGGi eba:ebA6002.
PATRICi 20973075. VBIAroAro98752_3455.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci AARO76114:GJTA-3479-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiLPXB_AROAE
AccessioniPrimary (citable) accession number: Q5NZG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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