Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5NZ93 (GCSP_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:AZOSEA34960
ORF Names:ebA6124
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum

Protein attributes

Sequence length972 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 972972Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227090

Amino acid modifications

Modified residue7131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5NZ93 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 8B37141C4012F18B

FASTA972103,927
        10         20         30         40         50         60 
MPNASPASPL NAPLAELEQR DAFIGRHVGP NATEIATMLA AVGAPDLDTL IDQTVPPAIR 

        70         80         90        100        110        120 
LAAPLPLEGP KPEHEALADL RAIAAKNVIR KSLIGMGYYG THTPAVILRN VMENPGWYTA 

       130        140        150        160        170        180 
YTPYQAEIAQ GRLEALLNYQ QMVIDLTGLE LANASLLDEA TAAAEAMTMA RRVAKSKSNV 

       190        200        210        220        230        240 
FYVDEACFPQ TIDVLRTRAG LFGFELKFGP AHDAANADAF GALLQYPNER GEIIDLSGTV 

       250        260        270        280        290        300 
AALKAKGAVV AIASDLMALV LLKSPGTMGA DIALGSAQRF GVPMGFGGPH AAFFATREAN 

       310        320        330        340        350        360 
VRAMPGRIIG VSKDARGKTA LRMTLQTREQ HIRREKANSN ICTSQVLLAN MSGFYAVYHG 

       370        380        390        400        410        420 
PQGLRTIAAR IHRLAAILAQ GLRDAGFNVP AGAFFDTLQV DTGARTAELL AACDAAGFNL 

       430        440        450        460        470        480 
RPVSDTVLGL SVDETTTGDD VATLLRLFGA SGELAALDAK VGAAGGAIPA ALLRDDAILT 

       490        500        510        520        530        540 
HPVFNTHHTE HEMLRYLKKL QNRDLALDHS MISLGSCTMK LNATSEMIPI TWAEFANLHP 

       550        560        570        580        590        600 
FAPREQVRGY LEMIDGLAGY LKAVTGFAAI SMQPNSGAQG EYAGLVAIRR YHDSRGDTHR 

       610        620        630        640        650        660 
RVCLIPKSAH GTNPASAQMC GMDVVVVACD ERGNVDLADL EAKVAQHADR LAALMITYPS 

       670        680        690        700        710        720 
THGVFEESIR EICASVHRHG GQVYMDGANL NAQVGLTSPA TIGADVSHMN LHKTFCIPHG 

       730        740        750        760        770        780 
GGGPGMGPIG LAAHLAPFMA DHVVAATGDE TRPNKGQGAV SAAPFGSASI LPISWMYIAM 

       790        800        810        820        830        840 
MGDTGLKLAT EVAILNANYV ANRLAEHYPV LYTGSQGRVA HECILDIRPI KANTGISEVD 

       850        860        870        880        890        900 
IAKRLMDYGF HAPTMSFPVA GTIMIEPTES EDLGELDRFI AAMITIRNEI REVENGAWPT 

       910        920        930        940        950        960 
DDNPLKNAPH TQADFIAADG AQWSRPYSRE QAVFPLPWVA ENKFWPSVNR IDDVYGDRNL 

       970 
FCACVPIEDY AS 

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR555306 Genomic DNA. Translation: CAI09621.1.
RefSeqYP_160522.1. NC_006513.1.

3D structure databases

ProteinModelPortalQ5NZ93.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING76114.ebA6124.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI09621; CAI09621; ebA6124.
GeneID3179225.
KEGGeba:ebA6124.
PATRIC20973201. VBIAroAro98752_3518.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMATAYLTHP.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycAARO76114:GJTA-3548-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_AROAE
AccessionPrimary (citable) accession number: Q5NZ93
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families