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Q5NZ93

- GCSP_AROAE

UniProt

Q5NZ93 - GCSP_AROAE

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, AZOSEA34960, ebA6124
Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAARO76114:GJTA-3548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:AZOSEA34960
ORF Names:ebA6124
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 972972Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi76114.ebA6124.

Structurei

3D structure databases

ProteinModelPortaliQ5NZ93.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NZ93-1 [UniParc]FASTAAdd to Basket

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MPNASPASPL NAPLAELEQR DAFIGRHVGP NATEIATMLA AVGAPDLDTL    50
IDQTVPPAIR LAAPLPLEGP KPEHEALADL RAIAAKNVIR KSLIGMGYYG 100
THTPAVILRN VMENPGWYTA YTPYQAEIAQ GRLEALLNYQ QMVIDLTGLE 150
LANASLLDEA TAAAEAMTMA RRVAKSKSNV FYVDEACFPQ TIDVLRTRAG 200
LFGFELKFGP AHDAANADAF GALLQYPNER GEIIDLSGTV AALKAKGAVV 250
AIASDLMALV LLKSPGTMGA DIALGSAQRF GVPMGFGGPH AAFFATREAN 300
VRAMPGRIIG VSKDARGKTA LRMTLQTREQ HIRREKANSN ICTSQVLLAN 350
MSGFYAVYHG PQGLRTIAAR IHRLAAILAQ GLRDAGFNVP AGAFFDTLQV 400
DTGARTAELL AACDAAGFNL RPVSDTVLGL SVDETTTGDD VATLLRLFGA 450
SGELAALDAK VGAAGGAIPA ALLRDDAILT HPVFNTHHTE HEMLRYLKKL 500
QNRDLALDHS MISLGSCTMK LNATSEMIPI TWAEFANLHP FAPREQVRGY 550
LEMIDGLAGY LKAVTGFAAI SMQPNSGAQG EYAGLVAIRR YHDSRGDTHR 600
RVCLIPKSAH GTNPASAQMC GMDVVVVACD ERGNVDLADL EAKVAQHADR 650
LAALMITYPS THGVFEESIR EICASVHRHG GQVYMDGANL NAQVGLTSPA 700
TIGADVSHMN LHKTFCIPHG GGGPGMGPIG LAAHLAPFMA DHVVAATGDE 750
TRPNKGQGAV SAAPFGSASI LPISWMYIAM MGDTGLKLAT EVAILNANYV 800
ANRLAEHYPV LYTGSQGRVA HECILDIRPI KANTGISEVD IAKRLMDYGF 850
HAPTMSFPVA GTIMIEPTES EDLGELDRFI AAMITIRNEI REVENGAWPT 900
DDNPLKNAPH TQADFIAADG AQWSRPYSRE QAVFPLPWVA ENKFWPSVNR 950
IDDVYGDRNL FCACVPIEDY AS 972
Length:972
Mass (Da):103,927
Last modified:January 4, 2005 - v1
Checksum:i8B37141C4012F18B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI09621.1.
RefSeqiYP_160522.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI09621; CAI09621; ebA6124.
GeneIDi3179225.
KEGGieba:ebA6124.
PATRICi20973201. VBIAroAro98752_3518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI09621.1 .
RefSeqi YP_160522.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5NZ93.
ModBasei Search...

Protein-protein interaction databases

STRINGi 76114.ebA6124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI09621 ; CAI09621 ; ebA6124 .
GeneIDi 3179225.
KEGGi eba:ebA6124.
PATRICi 20973201. VBIAroAro98752_3518.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AARO76114:GJTA-3548-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiGCSP_AROAE
AccessioniPrimary (citable) accession number: Q5NZ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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