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Q5NZ93

- GCSP_AROAE

UniProt

Q5NZ93 - GCSP_AROAE

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciAARO76114:GJTA-3548-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:AZOSEA34960
    ORF Names:ebA6124
    OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
    Taxonomic identifieri76114 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
    ProteomesiUP000006552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 972972Glycine dehydrogenase (decarboxylating)PRO_0000227090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi76114.ebA6124.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NZ93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5NZ93-1 [UniParc]FASTAAdd to Basket

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    MPNASPASPL NAPLAELEQR DAFIGRHVGP NATEIATMLA AVGAPDLDTL    50
    IDQTVPPAIR LAAPLPLEGP KPEHEALADL RAIAAKNVIR KSLIGMGYYG 100
    THTPAVILRN VMENPGWYTA YTPYQAEIAQ GRLEALLNYQ QMVIDLTGLE 150
    LANASLLDEA TAAAEAMTMA RRVAKSKSNV FYVDEACFPQ TIDVLRTRAG 200
    LFGFELKFGP AHDAANADAF GALLQYPNER GEIIDLSGTV AALKAKGAVV 250
    AIASDLMALV LLKSPGTMGA DIALGSAQRF GVPMGFGGPH AAFFATREAN 300
    VRAMPGRIIG VSKDARGKTA LRMTLQTREQ HIRREKANSN ICTSQVLLAN 350
    MSGFYAVYHG PQGLRTIAAR IHRLAAILAQ GLRDAGFNVP AGAFFDTLQV 400
    DTGARTAELL AACDAAGFNL RPVSDTVLGL SVDETTTGDD VATLLRLFGA 450
    SGELAALDAK VGAAGGAIPA ALLRDDAILT HPVFNTHHTE HEMLRYLKKL 500
    QNRDLALDHS MISLGSCTMK LNATSEMIPI TWAEFANLHP FAPREQVRGY 550
    LEMIDGLAGY LKAVTGFAAI SMQPNSGAQG EYAGLVAIRR YHDSRGDTHR 600
    RVCLIPKSAH GTNPASAQMC GMDVVVVACD ERGNVDLADL EAKVAQHADR 650
    LAALMITYPS THGVFEESIR EICASVHRHG GQVYMDGANL NAQVGLTSPA 700
    TIGADVSHMN LHKTFCIPHG GGGPGMGPIG LAAHLAPFMA DHVVAATGDE 750
    TRPNKGQGAV SAAPFGSASI LPISWMYIAM MGDTGLKLAT EVAILNANYV 800
    ANRLAEHYPV LYTGSQGRVA HECILDIRPI KANTGISEVD IAKRLMDYGF 850
    HAPTMSFPVA GTIMIEPTES EDLGELDRFI AAMITIRNEI REVENGAWPT 900
    DDNPLKNAPH TQADFIAADG AQWSRPYSRE QAVFPLPWVA ENKFWPSVNR 950
    IDDVYGDRNL FCACVPIEDY AS 972
    Length:972
    Mass (Da):103,927
    Last modified:January 4, 2005 - v1
    Checksum:i8B37141C4012F18B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI09621.1.
    RefSeqiYP_160522.1. NC_006513.1.

    Genome annotation databases

    EnsemblBacteriaiCAI09621; CAI09621; ebA6124.
    GeneIDi3179225.
    KEGGieba:ebA6124.
    PATRICi20973201. VBIAroAro98752_3518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI09621.1 .
    RefSeqi YP_160522.1. NC_006513.1.

    3D structure databases

    ProteinModelPortali Q5NZ93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 76114.ebA6124.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI09621 ; CAI09621 ; ebA6124 .
    GeneIDi 3179225.
    KEGGi eba:ebA6124.
    PATRICi 20973201. VBIAroAro98752_3518.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci AARO76114:GJTA-3548-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
      Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
      Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EbN1.

    Entry informationi

    Entry nameiGCSP_AROAE
    AccessioniPrimary (citable) accession number: Q5NZ93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3