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Q5NZ93

- GCSP_AROAE

UniProt

Q5NZ93 - GCSP_AROAE

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAARO76114:GJTA-3548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:AZOSEA34960
ORF Names:ebA6124
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 972972Glycine dehydrogenase (decarboxylating)PRO_0000227090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi76114.ebA6124.

Structurei

3D structure databases

ProteinModelPortaliQ5NZ93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NZ93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNASPASPL NAPLAELEQR DAFIGRHVGP NATEIATMLA AVGAPDLDTL
60 70 80 90 100
IDQTVPPAIR LAAPLPLEGP KPEHEALADL RAIAAKNVIR KSLIGMGYYG
110 120 130 140 150
THTPAVILRN VMENPGWYTA YTPYQAEIAQ GRLEALLNYQ QMVIDLTGLE
160 170 180 190 200
LANASLLDEA TAAAEAMTMA RRVAKSKSNV FYVDEACFPQ TIDVLRTRAG
210 220 230 240 250
LFGFELKFGP AHDAANADAF GALLQYPNER GEIIDLSGTV AALKAKGAVV
260 270 280 290 300
AIASDLMALV LLKSPGTMGA DIALGSAQRF GVPMGFGGPH AAFFATREAN
310 320 330 340 350
VRAMPGRIIG VSKDARGKTA LRMTLQTREQ HIRREKANSN ICTSQVLLAN
360 370 380 390 400
MSGFYAVYHG PQGLRTIAAR IHRLAAILAQ GLRDAGFNVP AGAFFDTLQV
410 420 430 440 450
DTGARTAELL AACDAAGFNL RPVSDTVLGL SVDETTTGDD VATLLRLFGA
460 470 480 490 500
SGELAALDAK VGAAGGAIPA ALLRDDAILT HPVFNTHHTE HEMLRYLKKL
510 520 530 540 550
QNRDLALDHS MISLGSCTMK LNATSEMIPI TWAEFANLHP FAPREQVRGY
560 570 580 590 600
LEMIDGLAGY LKAVTGFAAI SMQPNSGAQG EYAGLVAIRR YHDSRGDTHR
610 620 630 640 650
RVCLIPKSAH GTNPASAQMC GMDVVVVACD ERGNVDLADL EAKVAQHADR
660 670 680 690 700
LAALMITYPS THGVFEESIR EICASVHRHG GQVYMDGANL NAQVGLTSPA
710 720 730 740 750
TIGADVSHMN LHKTFCIPHG GGGPGMGPIG LAAHLAPFMA DHVVAATGDE
760 770 780 790 800
TRPNKGQGAV SAAPFGSASI LPISWMYIAM MGDTGLKLAT EVAILNANYV
810 820 830 840 850
ANRLAEHYPV LYTGSQGRVA HECILDIRPI KANTGISEVD IAKRLMDYGF
860 870 880 890 900
HAPTMSFPVA GTIMIEPTES EDLGELDRFI AAMITIRNEI REVENGAWPT
910 920 930 940 950
DDNPLKNAPH TQADFIAADG AQWSRPYSRE QAVFPLPWVA ENKFWPSVNR
960 970
IDDVYGDRNL FCACVPIEDY AS
Length:972
Mass (Da):103,927
Last modified:January 4, 2005 - v1
Checksum:i8B37141C4012F18B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI09621.1.
RefSeqiYP_160522.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI09621; CAI09621; ebA6124.
GeneIDi3179225.
KEGGieba:ebA6124.
PATRICi20973201. VBIAroAro98752_3518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI09621.1 .
RefSeqi YP_160522.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5NZ93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76114.ebA6124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI09621 ; CAI09621 ; ebA6124 .
GeneIDi 3179225.
KEGGi eba:ebA6124.
PATRICi 20973201. VBIAroAro98752_3518.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AARO76114:GJTA-3548-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiGCSP_AROAE
AccessioniPrimary (citable) accession number: Q5NZ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3