Reviewed,
UniProtKB/Swiss-Prot Q5NYA9 (MDH_AZOSE)
Last modified
June 16, 2009.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Malate dehydrogenase EC=1.1.1.37 | ||||||
| Gene names |
| ||||||
| Organism | Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 76114 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum |
Protein attributes
| Sequence length | 329 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. |
| Catalytic activity | (S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: InterPro malate metabolic processInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: HAMAP |
| Molecular function | L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 329 | 329 | Malate dehydrogenase HAMAP MF_01517 | PRO_0000113347 | |||||
Regions | |||||||||
| Nucleotide binding | 12 – 18 | 7 | NAD By similarity | ||||||
| Nucleotide binding | 130 – 132 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 191 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 93 | 1 | Substrate By similarity | ||||||
| Binding site | 99 | 1 | Substrate By similarity | ||||||
| Binding site | 106 | 1 | NAD By similarity | ||||||
| Binding site | 113 | 1 | NAD By similarity | ||||||
| Binding site | 132 | 1 | Substrate By similarity | ||||||
| Binding site | 166 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CR555306 Genomic DNA. Translation: CAI09955.1. | |
| RefSeq | YP_160856.1. |
3D structure databases | |
| SMR | Q5NYA9. Positions 3-328. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3181211. |
| GenomeReviews | Gene locus AZOSEA38300 in contig CR555306_GR. |
| KEGG | eba:ebA6695. |
| NMPDR | fig|76114.4.peg.3846. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q5NYA9. |
| OMA | Q5NYA9. MIIWGNH. |
Enzyme and pathway databases | |
| BioCyc | ASP76114:EBA6695-MON. |
Family and domain databases | |
| HAMAP | MF_01517. [Tree] |
| InterPro | IPR001557. L-lactate/malate_DH. IPR001236. Lactate/malate_DH. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010945. Malate_DH_SF1. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR23382. MDH_SF1. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| ProDom | PD003052. Mal_dehydrog. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01759. MalateDH-SF1. 1 hit. |
| PROSITE | PS00068. MDH. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDH_AZOSE | ||||||||
| Accession | Primary (citable) accession number: Q5NYA9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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