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Q5NXR0

- PUR5_AROAE

UniProt

Q5NXR0 - PUR5_AROAE

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAARO76114:GJTA-4085-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:AZOSEA40290
ORF Names:ebA7104
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258327Add
BLAST

Proteomic databases

PRIDEiQ5NXR0.

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA7104.

Structurei

3D structure databases

ProteinModelPortaliQ5NXR0.
SMRiQ5NXR0. Positions 7-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NXR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPKPSLSY RDAGVDIDAG DALVDRIKPL AKRTMRPEVL GGIGGFGALF
60 70 80 90 100
ELSKKYREPV LVSGTDGVGT KLKLAFQLNR HDTVGQDLVA MSVNDILVQG
110 120 130 140 150
AEPLFFLDYF ACGKLDVDTA AAVVSGIARG CELSGCALIG GETAEMHGMY
160 170 180 190 200
PDGEYDLAGF AVGAVEKSEI IDGSRIVPGD VVLGLASSGA HSNGYSLIRK
210 220 230 240 250
IIDLAKPDLD ADFHGRPLRD VILEPTRLYV KPMLGLMQAI PGVVKGMAHI
260 270 280 290 300
TGGGLLENVP RILADGLAAR LDVSSWTLPP LFQWLRDAGN VDAQEMYRVF
310 320 330 340
NCGVGMVVIV SAAQAGAAVQ NLEAAGEIVY RLGRIESRAE GAAQTTVG
Length:348
Mass (Da):36,666
Last modified:January 4, 2005 - v1
Checksum:iA0D2757D48C1610F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI10154.1.
RefSeqiYP_161055.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI10154; CAI10154; ebA7104.
GeneIDi3180766.
KEGGieba:ebA7104.
PATRICi20974303. VBIAroAro98752_4065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI10154.1 .
RefSeqi YP_161055.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5NXR0.
SMRi Q5NXR0. Positions 7-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76114.ebA7104.

Proteomic databases

PRIDEi Q5NXR0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI10154 ; CAI10154 ; ebA7104 .
GeneIDi 3180766.
KEGGi eba:ebA7104.
PATRICi 20974303. VBIAroAro98752_4065.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci AARO76114:GJTA-4085-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiPUR5_AROAE
AccessioniPrimary (citable) accession number: Q5NXR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3