Reviewed, UniProtKB/Swiss-Prot Q5NVS8 (ALG6_PONAB)

Names and origin

Protein names

Recommended name:
    Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
    EC=2.4.1.-
Alternative name(s):
    Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
    Asparagine-linked glycosylation protein 6

Gene names

Name:

ALG6

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man9GlcNAc(2)-PP-Dol By similarity.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ALG6/ALG8 glucosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring hexosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase		PRO_0000284131
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	115 – 135	21	Potential
	Transmembrane	144 – 164	21	Potential
	Transmembrane	173 – 193	21	Potential
	Transmembrane	227 – 247	21	Potential
	Transmembrane	298 – 318	21	Potential
	Transmembrane	324 – 344	21	Potential
	Transmembrane	362 – 382	21	Potential
	Transmembrane	388 – 408	21	Potential
	Transmembrane	438 – 458	21	Potential
	Transmembrane	473 – 493	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5NVS8-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: ADF072D16671D9B9	FASTA	507	58,075
	10 20 30 40 50 60 MEKWYLMTVV VLIGLTVRWT VSLNSYSGAG KPPMFGDYEA QRHWQEITFN LPVKQWYFNS 70 80 90 100 110 120 SDNNLQYWGL DYPPPTAYHS LLCAYVAKFI NPDWIALHTS RGYESQAHKL FMRTTVLIAD 130 140 150 160 170 180 LLIYIPAVVL YCCCLKEIST KKKIANALCI LLYPGLILID YGHFQYNSVS LGFALWGVLG 190 200 210 220 230 240 ISCDCDLLGS LAFCLAINYK QMELYHALPF FCFLLGKCFK KGLKGKGFVL LVKLACIVVA 250 260 270 280 290 300 SFVLCWLPFF TEREQTLQVL RRLFPVDRGL FEDKVANIWC SFNVFLKIKD ILPRHIQLIM 310 320 330 340 350 360 SFCFTFLSLL PACIKLILQP SSKGFKFTLV SCALSFFLFS FQVHEKSILL VSLPVCLVLS 370 380 390 400 410 420 EIPFMSTWFL LVSTFSMLPL LLKDELLMPS VVTTMAFFIA CVTSFSIFEK TSEEELQLKS 430 440 450 460 470 480 FSISVRKYLP CFTFLSRIIQ YLFLISVITM VLLTLMTVTL GPPQKLPDLF SVLVCFVSCL 490 500 NFLFFLVYFN IIIVWDSKSG RNQKKIS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR925922 mRNA. Translation: CAI29585.1.
RefSeq	NP_001127060.1.
UniGene	Pab.14434
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT57. Glycosyltransferase Family 57.
Genome annotation databases
GeneID	100174089.
Organism-specific databases
CTD	100174089.
Phylogenomic databases
HOVERGEN	Q5NVS8.
Family and domain databases
InterPro	IPR004856. Glycosyltransferase_ALG6/ALG8. [Graphical view]
PANTHER	PTHR12413. Alg6_Alg8. 1 hit.
Pfam	PF03155. Alg6_Alg8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALG6_PONAB

Accession

Primary (citable) accession number: Q5NVS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	January 4, 2005
Last modified:	October 13, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)