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Protein

Histone H1.0

Gene

H1F0

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.0
Alternative name(s):
Histone H1(0)
Cleaved into the following chain:
Gene namesi
Name:H1F0
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Histone H1.0PRO_0000259964Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 194193Histone H1.0, N-terminally processedPRO_0000423209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylthreonine; in Histone H1.0, N-terminally processedBy similarity
Modified residuei42 – 421CitrullineBy similarity

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

PRIDEiQ5NVN9.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013165.

Structurei

3D structure databases

ProteinModelPortaliQ5NVN9.
SMRiQ5NVN9. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9774H15PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOVERGENiHBG069502.
InParanoidiQ5NVN9.
KOiK11275.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NVN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MVVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE
110 120 130 140 150
PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL
160 170 180 190
AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK
Length:194
Mass (Da):20,849
Last modified:January 23, 2007 - v3
Checksum:i1AC5C7021B24B071
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925976 mRNA. Translation: CAI29624.1.
RefSeqiNP_001127680.1. NM_001134208.1.

Genome annotation databases

GeneIDi100174762.
KEGGipon:100174762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925976 mRNA. Translation: CAI29624.1.
RefSeqiNP_001127680.1. NM_001134208.1.

3D structure databases

ProteinModelPortaliQ5NVN9.
SMRiQ5NVN9. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013165.

Proteomic databases

PRIDEiQ5NVN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174762.
KEGGipon:100174762.

Organism-specific databases

CTDi3005.

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOVERGENiHBG069502.
InParanoidiQ5NVN9.
KOiK11275.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiH10_PONAB
AccessioniPrimary (citable) accession number: Q5NVN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.