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Protein

Histone H1.0

Gene

H1F0

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.0
Alternative name(s):
Histone H1(0)
Cleaved into the following chain:
Gene namesi
Name:H1F0
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232091 – 194Histone H1.0Add BLAST194
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00002599642 – 194Histone H1.0, N-terminally processedAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Histone H1.0, N-terminally processedBy similarity1
Modified residuei42CitrullineBy similarity1
Modified residuei104ADP-ribosylserineBy similarity1

Post-translational modificationi

ADP-ribosylated on Ser-104 in response to DNA damage.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Citrullination

Proteomic databases

PRIDEiQ5NVN9.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013165.

Structurei

3D structure databases

ProteinModelPortaliQ5NVN9.
SMRiQ5NVN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 97H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOVERGENiHBG069502.
InParanoidiQ5NVN9.
KOiK11275.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00538. Linker_histone. 1 hit.
PRINTSiPR00624. HISTONEH5.
SMARTiView protein in SMART
SM00526. H15. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS51504. H15. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NVN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MVVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE
110 120 130 140 150
PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL
160 170 180 190
AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK
Length:194
Mass (Da):20,849
Last modified:January 23, 2007 - v3
Checksum:i1AC5C7021B24B071
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925976 mRNA. Translation: CAI29624.1.
RefSeqiNP_001127680.1. NM_001134208.1.

Genome annotation databases

GeneIDi100174762.
KEGGipon:100174762.

Similar proteinsi

Entry informationi

Entry nameiH10_PONAB
AccessioniPrimary (citable) accession number: Q5NVN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 75 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families