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Q5NVK5

- PGTA_PONAB

UniProt

Q5NVK5 - PGTA_PONAB

Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

RABGGTA

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.By similarity

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    Enzyme regulationi

    The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.By similarity

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein geranylgeranylation Source: UniProtKB

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
    Alternative name(s):
    Geranylgeranyl transferase type II subunit alpha
    Rab geranyl-geranyltransferase subunit alpha
    Short name:
    Rab GG transferase alpha
    Short name:
    Rab GGTase alpha
    Rab geranylgeranyltransferase subunit alpha
    Gene namesi
    Name:RABGGTA
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Geranylgeranyl transferase type-2 subunit alphaPRO_0000229771Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NVK5.
    SMRiQ5NVK5. Positions 2-567.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati44 – 7835PFTA 1Add
    BLAST
    Repeati88 – 12235PFTA 2Add
    BLAST
    Repeati124 – 15835PFTA 3Add
    BLAST
    Repeati159 – 19335PFTA 4Add
    BLAST
    Repeati207 – 24135PFTA 5Add
    BLAST
    Repeati363 – 39735PFTA 6Add
    BLAST
    Repeati442 – 46322LRR 1Add
    BLAST
    Repeati464 – 48623LRR 2Add
    BLAST
    Repeati487 – 50822LRR 3Add
    BLAST
    Repeati509 – 53022LRR 4Add
    BLAST
    Repeati534 – 55522LRR 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 6 PFTA repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    HOVERGENiHBG002171.
    InParanoidiQ5NVK5.
    KOiK14050.

    Family and domain databases

    Gene3Di2.60.40.1130. 1 hit.
    InterProiIPR001611. Leu-rich_rpt.
    IPR002088. Prenyl_trans_a.
    IPR009087. RabGGT_asu_insert-domain.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF01239. PPTA. 5 hits.
    PF07711. RabGGT_insert. 1 hit.
    [Graphical view]
    ProDomiPD331837. RabGG_trans_A. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF49594. SSF49594. 1 hit.
    PROSITEiPS51450. LRR. 5 hits.
    PS51147. PFTA. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NVK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE    50
    LTSQILGANP DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL 100
    RVNPKSYGTW HHRCWLLGRL PEPNWTRELE LCARFLEVDE RNFHCWDYRR 150
    FVATQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ 200
    GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV 250
    SREEACLTVS FSRPLLVGSR TEILLLMVDD SPLIVEWRTP DGRNRPSHVW 300
    LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ 350
    LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY 400
    EKETLRYFQT LKAVDPMRAA YLDDLRSKFL LENSVLKMEY AEVRVLHLAH 450
    KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP ALAALRCLEV LQASDNAIES 500
    LDGVTNLPRL QELLLCNNRL QRPAVLQPLA SCPRLVLLNL QGNPLCQAVG 550
    ILEQLAELPP SVNSILT 567
    Length:567
    Mass (Da):65,107
    Last modified:January 4, 2005 - v1
    Checksum:i6C511480882981F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926021 mRNA. Translation: CAI29658.1.
    RefSeqiNP_001127096.1. NM_001133624.1.
    UniGeneiPab.536.

    Genome annotation databases

    GeneIDi100174130.
    KEGGipon:100174130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926021 mRNA. Translation: CAI29658.1 .
    RefSeqi NP_001127096.1. NM_001133624.1.
    UniGenei Pab.536.

    3D structure databases

    ProteinModelPortali Q5NVK5.
    SMRi Q5NVK5. Positions 2-567.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174130.
    KEGGi pon:100174130.

    Organism-specific databases

    CTDi 5875.

    Phylogenomic databases

    HOVERGENi HBG002171.
    InParanoidi Q5NVK5.
    KOi K14050.

    Family and domain databases

    Gene3Di 2.60.40.1130. 1 hit.
    InterProi IPR001611. Leu-rich_rpt.
    IPR002088. Prenyl_trans_a.
    IPR009087. RabGGT_asu_insert-domain.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF01239. PPTA. 5 hits.
    PF07711. RabGGT_insert. 1 hit.
    [Graphical view ]
    ProDomi PD331837. RabGG_trans_A. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF49594. SSF49594. 1 hit.
    PROSITEi PS51450. LRR. 5 hits.
    PS51147. PFTA. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiPGTA_PONAB
    AccessioniPrimary (citable) accession number: Q5NVK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3