Q5NVK5 (PGTA_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Geranylgeranyl transferase type-2 subunit alpha
EC=2.5.1.60

Alternative name(s):
Geranylgeranyl transferase type II subunit alpha
Rab geranyl-geranyltransferase subunit alpha
Short name=Rab GG transferase alpha
Short name=Rab GGTase alpha
Rab geranylgeranyltransferase subunit alpha

Gene names

Name:

RABGGTA

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively By similarity.
Catalytic activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Cofactor	Binds 1 zinc ion per dimer By similarity.
Enzyme regulation	The enzymatic reaction requires the aid of a Rab escort protein (also called component A) By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit, collectively called component B By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit alpha family. Contains 5 LRR (leucine-rich) repeats. Contains 6 PFTA repeats.

Ontologies

Keywords
Domain	Leucine-rich repeat Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
Gene Ontology (GO)
Biological process	protein prenylation Inferred from electronic annotation. Source: InterPro
Molecular function	Rab geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 567	567	Geranylgeranyl transferase type-2 subunit alpha		PRO_0000229771
Regions
	Repeat	44 – 78	35	PFTA 1
	Repeat	88 – 122	35	PFTA 2
	Repeat	124 – 158	35	PFTA 3
	Repeat	159 – 193	35	PFTA 4
	Repeat	207 – 241	35	PFTA 5
	Repeat	363 – 397	35	PFTA 6
	Repeat	442 – 463	22	LRR 1
	Repeat	464 – 486	23	LRR 2
	Repeat	487 – 508	22	LRR 3
	Repeat	509 – 530	22	LRR 4
	Repeat	534 – 555	22	LRR 5
Sites
	Metal binding	2	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5NVK5 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 6C511480882981F2	FASTA	567	65,107
	10 20 30 40 50 60 MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE LTSQILGANP 70 80 90 100 110 120 DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL RVNPKSYGTW HHRCWLLGRL 130 140 150 160 170 180 PEPNWTRELE LCARFLEVDE RNFHCWDYRR FVATQAAVPP AEELAFTDSL ITRNFSNYSS 190 200 210 220 230 240 WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD 250 260 270 280 290 300 PQDALRCLHV SREEACLTVS FSRPLLVGSR TEILLLMVDD SPLIVEWRTP DGRNRPSHVW 310 320 330 340 350 360 LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ LFRCELSVEK 370 380 390 400 410 420 STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLRYFQT LKAVDPMRAA 430 440 450 460 470 480 YLDDLRSKFL LENSVLKMEY AEVRVLHLAH KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP 490 500 510 520 530 540 ALAALRCLEV LQASDNAIES LDGVTNLPRL QELLLCNNRL QRPAVLQPLA SCPRLVLLNL 550 560 QGNPLCQAVG ILEQLAELPP SVNSILT

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR926021 mRNA. Translation: CAI29658.1.
RefSeq	NP_001127096.1. NM_001133624.1.
UniGene	Pab.536.
3D structure databases
ProteinModelPortal	Q5NVK5.
SMR	Q5NVK5. Positions 2-567.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100174130.
KEGG	pon:100174130.
Organism-specific databases
CTD	5875.
Phylogenomic databases
HOVERGEN	HBG002171.
InParanoid	Q5NVK5.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. IPR009087. RabGGT_asu_insert-domain. [Graphical view]
Gene3D	G3DSA:1.25.40.120. Prenyl_trans. 2 hits. G3DSA:2.60.40.1130. RabGGT_asu_insert-domain. 1 hit.
KO	K14050.
Pfam	PF00560. LRR_1. 1 hit. PF01239. PPTA. 5 hits. PF07711. RabGGT_insert. 1 hit. [Graphical view]
ProDom	PD331837. RabGG_trans_A. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF49594. RabGG_trans_A. 1 hit.
PROSITE	PS51450. LRR. 5 hits. PS51147. PFTA. 6 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGTA_PONAB

Accession

Primary (citable) accession number: Q5NVK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	January 4, 2005
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program