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Q5NVK2

- WNT5B_PONAB

UniProt

Q5NVK2 - WNT5B_PONAB

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Protein

Protein Wnt-5b

Gene
WNT5B
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

GO - Molecular functioni

  1. receptor binding Source: UniProtKB

GO - Biological processi

  1. chondrocyte differentiation Source: Ensembl
  2. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  3. positive regulation of cell migration Source: UniProtKB
  4. positive regulation of fat cell differentiation Source: Ensembl
  5. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:WNT5B
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 359342Protein Wnt-5bPRO_0000229769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 94 By similarity
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi133 ↔ 141 By similarity
Disulfide bondi143 ↔ 161 By similarity
Disulfide bondi217 ↔ 231 By similarity
Disulfide bondi219 ↔ 226 By similarity
Lipidationi223 – 2231O-palmitoyl serine; by PORCN By similarity
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi304 ↔ 319 By similarity
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi334 ↔ 349 By similarity
Disulfide bondi336 ↔ 346 By similarity
Disulfide bondi341 ↔ 342 By similarity

Post-translational modificationi

Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with PORCN By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00740000115016.
HOVERGENiHBG001595.
InParanoidiQ5NVK2.
KOiK00444.
OMAiLTDANSW.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NVK2-1 [UniParc]FASTAAdd to Basket

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MPSLLLLFTA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ    50
LPGLSPGQRK LCQLYQEHMA YIGEGAKTGI KECQHQFRQR RWNCSTVDNA 100
SVFGRVMQIG SRETAFTYAV SAAGVVNAIS RACREGELST CGCSRTARPK 150
DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRVLMNLQ 200
NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD 250
SAAAMRVTRK GRLELVNSRF TQPTPEDLVY VDPSPDYCLR NESTGSLGTQ 300
GRLCNKTSEG MDGCELMCCG RGYNQFKSVQ VERCHCKFHW CCFVKCKKCT 350
EIVDQYICK 359
Length:359
Mass (Da):40,349
Last modified:January 4, 2005 - v1
Checksum:iB932E2CC374B8805
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926024 mRNA. Translation: CAI29661.1.
RefSeqiNP_001127098.1. NM_001133626.1.
UniGeneiPab.711.

Genome annotation databases

EnsembliENSPPYT00000004905; ENSPPYP00000004719; ENSPPYG00000004141.
GeneIDi100174132.
KEGGipon:100174132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926024 mRNA. Translation: CAI29661.1 .
RefSeqi NP_001127098.1. NM_001133626.1.
UniGenei Pab.711.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000004905 ; ENSPPYP00000004719 ; ENSPPYG00000004141 .
GeneIDi 100174132.
KEGGi pon:100174132.

Organism-specific databases

CTDi 81029.

Phylogenomic databases

GeneTreei ENSGT00740000115016.
HOVERGENi HBG001595.
InParanoidi Q5NVK2.
KOi K00444.
OMAi LTDANSW.
OrthoDBi EOG7C8GJ8.
TreeFami TF105310.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiWNT5B_PONAB
AccessioniPrimary (citable) accession number: Q5NVK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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