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Q5NVK2

- WNT5B_PONAB

UniProt

Q5NVK2 - WNT5B_PONAB

Protein

Protein Wnt-5b

Gene

WNT5B

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. receptor binding Source: UniProtKB

    GO - Biological processi

    1. chondrocyte differentiation Source: Ensembl
    2. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    3. positive regulation of cell migration Source: UniProtKB
    4. positive regulation of fat cell differentiation Source: Ensembl
    5. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5b
    Gene namesi
    Name:WNT5B
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 12

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 359342Protein Wnt-5bPRO_0000229769Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 94By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 141By similarity
    Disulfide bondi143 ↔ 161By similarity
    Disulfide bondi217 ↔ 231By similarity
    Disulfide bondi219 ↔ 226By similarity
    Lipidationi223 – 2231O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 319By similarity
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi334 ↔ 349By similarity
    Disulfide bondi336 ↔ 346By similarity
    Disulfide bondi341 ↔ 342By similarity

    Post-translational modificationi

    Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Interactioni

    Subunit structurei

    Interacts with PORCN.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00740000115016.
    HOVERGENiHBG001595.
    InParanoidiQ5NVK2.
    KOiK00444.
    OMAiLTDANSW.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NVK2-1 [UniParc]FASTAAdd to Basket

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    MPSLLLLFTA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ    50
    LPGLSPGQRK LCQLYQEHMA YIGEGAKTGI KECQHQFRQR RWNCSTVDNA 100
    SVFGRVMQIG SRETAFTYAV SAAGVVNAIS RACREGELST CGCSRTARPK 150
    DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRVLMNLQ 200
    NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD 250
    SAAAMRVTRK GRLELVNSRF TQPTPEDLVY VDPSPDYCLR NESTGSLGTQ 300
    GRLCNKTSEG MDGCELMCCG RGYNQFKSVQ VERCHCKFHW CCFVKCKKCT 350
    EIVDQYICK 359
    Length:359
    Mass (Da):40,349
    Last modified:January 4, 2005 - v1
    Checksum:iB932E2CC374B8805
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926024 mRNA. Translation: CAI29661.1.
    RefSeqiNP_001127098.1. NM_001133626.1.
    UniGeneiPab.711.

    Genome annotation databases

    EnsembliENSPPYT00000004905; ENSPPYP00000004719; ENSPPYG00000004141.
    GeneIDi100174132.
    KEGGipon:100174132.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926024 mRNA. Translation: CAI29661.1 .
    RefSeqi NP_001127098.1. NM_001133626.1.
    UniGenei Pab.711.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000004905 ; ENSPPYP00000004719 ; ENSPPYG00000004141 .
    GeneIDi 100174132.
    KEGGi pon:100174132.

    Organism-specific databases

    CTDi 81029.

    Phylogenomic databases

    GeneTreei ENSGT00740000115016.
    HOVERGENi HBG001595.
    InParanoidi Q5NVK2.
    KOi K00444.
    OMAi LTDANSW.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiWNT5B_PONAB
    AccessioniPrimary (citable) accession number: Q5NVK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3