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Q5NVK2 (WNT5B_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subunit structure

Interacts with PORCN By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Post-translational modification

Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-83. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 359342Protein Wnt-5b
PRO_0000229769

Amino acid modifications

Lipidation831S-palmitoyl cysteine By similarity
Lipidation2231O-palmitoyl serine; by PORCN By similarity
Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Glycosylation3051N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5NVK2 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: B932E2CC374B8805

FASTA35940,349
        10         20         30         40         50         60 
MPSLLLLFTA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ LPGLSPGQRK 

        70         80         90        100        110        120 
LCQLYQEHMA YIGEGAKTGI KECQHQFRQR RWNCSTVDNA SVFGRVMQIG SRETAFTYAV 

       130        140        150        160        170        180 
SAAGVVNAIS RACREGELST CGCSRTARPK DLPRDWLWGG CGDNVEYGYR FAKEFVDARE 

       190        200        210        220        230        240 
REKNFAKGSE EQGRVLMNLQ NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK 

       250        260        270        280        290        300 
VGDRLKEKYD SAAAMRVTRK GRLELVNSRF TQPTPEDLVY VDPSPDYCLR NESTGSLGTQ 

       310        320        330        340        350 
GRLCNKTSEG MDGCELMCCG RGYNQFKSVQ VERCHCKFHW CCFVKCKKCT EIVDQYICK 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR926024 mRNA. Translation: CAI29661.1.
RefSeqNP_001127098.1. NM_001133626.1.
UniGenePab.711.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000004905; ENSPPYP00000004719; ENSPPYG00000004141.
GeneID100174132.
KEGGpon:100174132.

Organism-specific databases

CTD81029.

Phylogenomic databases

GeneTreeENSGT00740000115016.
HOVERGENHBG001595.
InParanoidQ5NVK2.
KOK00444.
OMALTDANSW.
OrthoDBEOG7C8GJ8.
TreeFamTF105310.

Family and domain databases

InterProIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF23. PTHR12027:SF23. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWNT5B_PONAB
AccessionPrimary (citable) accession number: Q5NVK2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 4, 2005
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families