Reviewed,
UniProtKB/Swiss-Prot Q5NVG2 (DHB11_PONAB)
Last modified
December 15, 2009.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Estradiol 17-beta-dehydrogenase 11 EC=1.1.1.62 Alternative name(s): 17-beta-hydroxysteroid dehydrogenase 11 Short name=17-beta-HSD 11 Short name=17betaHSD11 Short name=17bHSD11 17-beta-HSD XI Short name=17betaHSDXI Dehydrogenase/reductase SDR family member 8 | ||||
| Gene names |
| ||||
| Organism | Pongo abelii (Sumatran orangutan) | ||||
| Taxonomic identifier | 9601 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 300 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione By similarity. |
| Catalytic activity | Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H. |
| Subcellular location | Secreted Potential. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis |
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW steroid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||
| Chain | 20 – 300 | 281 | Estradiol 17-beta-dehydrogenase 11 | PRO_0000031972 | |||||
Regions | |||||||||
| Nucleotide binding | 40 – 64 | 25 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 185 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 172 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR926074 mRNA. Translation: CAI29701.1. |
| RefSeq | NP_001127691.1. |
| UniGene | Pab.18395 |
3D structure databases | |
| SMR | Q5NVG2. Positions 30-273. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 100174773. |
Organism-specific databases | |
| CTD | 100174773. |
Phylogenomic databases | |
| HOVERGEN | Q5NVG2. |
| InParanoid | Q5NVG2. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.62. 269192. |
Family and domain databases | |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHB11_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5NVG2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


