Reviewed, UniProtKB/Swiss-Prot Q5NVG2 (DHB11_PONAB)

Names and origin

Protein names

Recommended name:
    Estradiol 17-beta-dehydrogenase 11
    EC=1.1.1.62
Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase 11
      Short name=17-beta-HSD 11
      Short name=17betaHSD11
      Short name=17bHSD11
    17-beta-HSD XI
      Short name=17betaHSDXI
    Dehydrogenase/reductase SDR family member 8

Gene names

Name:	HSD17B11
Synonyms:	DHRS8

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione By similarity.
Catalytic activity	Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis
Cellular component	Secreted
Domain	Signal
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 300	281	Estradiol 17-beta-dehydrogenase 11		PRO_0000031972
Regions
	Nucleotide binding	40 – 64	25	NADP By similarity
Sites
	Active site	185	1	Proton acceptor By similarity
	Binding site	172	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5NVG2-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 982412E8EEE44083	FASTA	300	32,992
	10 20 30 40 50 60 MKFLLDVLLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR LTAYEFAKLK 70 80 90 100 110 120 SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI YSAAKKVKAE IGDVSILVNN 130 140 150 160 170 180 AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMM KNNHGHIVTV ASAAGHVSVP 190 200 210 220 230 240 FLLAYCSSKF AAVGFHKTLT DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE 250 260 270 280 290 300 EVVNRLMHGI LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKRKISVKFD AVIGYRMKAQ

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR926074 mRNA. Translation: CAI29701.1.
RefSeq	NP_001127691.1.
UniGene	Pab.18395
3D structure databases
SMR	Q5NVG2. Positions 30-273.
ModBase	Search...
Genome annotation databases
GeneID	100174773.
Organism-specific databases
CTD	100174773.
Phylogenomic databases
HOVERGEN	Q5NVG2.
InParanoid	Q5NVG2.
Enzyme and pathway databases
BRENDA	1.1.1.62. 269192.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHB11_PONAB

Accession

Primary (citable) accession number: Q5NVG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	January 4, 2005
Last modified:	December 15, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)