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Q5NVF6

- PPAL_PONAB

UniProt

Q5NVF6 - PPAL_PONAB

Protein

Lysosomal acid phosphatase

Gene

ACP2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei42 – 421NucleophileBy similarity
    Active sitei287 – 2871Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lysosome organization Source: Ensembl
    2. skeletal system development Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal acid phosphatase (EC:3.1.3.2)
    Short name:
    LAP
    Gene namesi
    Name:ACP2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 11

    Subcellular locationi

    Lysosome membrane By similarity; Single-pass membrane protein By similarity; Lumenal side By similarity. Lysosome lumen By similarity
    Note: The soluble form arises by proteolytic processing of the membrane-bound form.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal lumen Source: UniProtKB-SubCell
    3. lysosomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030By similarityAdd
    BLAST
    Chaini31 – 423393Lysosomal acid phosphatasePRO_0000352522Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi159 ↔ 370By similarity
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi212 ↔ 310By similarity
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi345 ↔ 349By similarity

    Post-translational modificationi

    The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NVF6.
    SMRiQ5NVF6. Positions 31-371.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 380350LumenalSequence AnalysisAdd
    BLAST
    Topological domaini402 – 42322CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00530000062956.
    HOGENOMiHOG000231439.
    HOVERGENiHBG002203.
    InParanoidiQ5NVF6.
    KOiK14410.
    OMAiQDFLHLT.
    OrthoDBiEOG7GXPBJ.
    TreeFamiTF312893.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NVF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGKRSGWSR AALLQLLLGV NLVVMPPTQA RSLRFVTLLY RHGDRSPVKT    50
    YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV 100
    YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR 150
    LLKFPLGPCP RYEQLQNETR QTPEYQNESS RNAQFLDMVA NETGLTDLTL 200
    ETVWNVYDTL FCEQTHGLRL PPWASPQTMQ RLSRLKDFSF RFLFGIYQQA 250
    EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY 300
    NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP 350
    LQDFLRLTEP VVPKDWQQEC QVASGPADTE VIVALAVCGS ILFLLIVLLL 400
    TVLFRMQAQP PGYRHVADGE DHA 423
    Length:423
    Mass (Da):48,302
    Last modified:January 4, 2005 - v1
    Checksum:i1A2CBFA5D8080E2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926080 mRNA. Translation: CAI29707.1.
    RefSeqiNP_001127113.1. NM_001133641.1.

    Genome annotation databases

    EnsembliENSPPYT00000003945; ENSPPYP00000003798; ENSPPYG00000003310.
    GeneIDi100174154.
    KEGGipon:100174154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR926080 mRNA. Translation: CAI29707.1 .
    RefSeqi NP_001127113.1. NM_001133641.1.

    3D structure databases

    ProteinModelPortali Q5NVF6.
    SMRi Q5NVF6. Positions 31-371.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000003945 ; ENSPPYP00000003798 ; ENSPPYG00000003310 .
    GeneIDi 100174154.
    KEGGi pon:100174154.

    Organism-specific databases

    CTDi 53.

    Phylogenomic databases

    GeneTreei ENSGT00530000062956.
    HOGENOMi HOG000231439.
    HOVERGENi HBG002203.
    InParanoidi Q5NVF6.
    KOi K14410.
    OMAi QDFLHLT.
    OrthoDBi EOG7GXPBJ.
    TreeFami TF312893.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiPPAL_PONAB
    AccessioniPrimary (citable) accession number: Q5NVF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3