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Q5NVF6

- PPAL_PONAB

UniProt

Q5NVF6 - PPAL_PONAB

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Protein

Lysosomal acid phosphatase

Gene
ACP2
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421Nucleophile By similarity
Active sitei287 – 2871Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. lysosome organization Source: Ensembl
  2. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal acid phosphatase (EC:3.1.3.2)
Short name:
LAP
Gene namesi
Name:ACP2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 11

Subcellular locationi

Lysosome membrane; Single-pass membrane protein; Lumenal side By similarity. Lysosome lumen By similarity
Note: The soluble form arises by proteolytic processing of the membrane-bound form By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 380350Lumenal Reviewed predictionAdd
BLAST
Transmembranei381 – 40121Helical; Reviewed predictionAdd
BLAST
Topological domaini402 – 42322Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal lumen Source: UniProtKB-SubCell
  3. lysosomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 By similarityAdd
BLAST
Chaini31 – 423393Lysosomal acid phosphatasePRO_0000352522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi159 ↔ 370 By similarity
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi212 ↔ 310 By similarity
Glycosylationi267 – 2671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi345 ↔ 349 By similarity

Post-translational modificationi

The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5NVF6.
SMRiQ5NVF6. Positions 31-371.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062956.
HOGENOMiHOG000231439.
HOVERGENiHBG002203.
InParanoidiQ5NVF6.
KOiK14410.
OMAiQDFLHLT.
OrthoDBiEOG7GXPBJ.
TreeFamiTF312893.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NVF6-1 [UniParc]FASTAAdd to Basket

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MAGKRSGWSR AALLQLLLGV NLVVMPPTQA RSLRFVTLLY RHGDRSPVKT    50
YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV 100
YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR 150
LLKFPLGPCP RYEQLQNETR QTPEYQNESS RNAQFLDMVA NETGLTDLTL 200
ETVWNVYDTL FCEQTHGLRL PPWASPQTMQ RLSRLKDFSF RFLFGIYQQA 250
EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY 300
NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP 350
LQDFLRLTEP VVPKDWQQEC QVASGPADTE VIVALAVCGS ILFLLIVLLL 400
TVLFRMQAQP PGYRHVADGE DHA 423
Length:423
Mass (Da):48,302
Last modified:January 4, 2005 - v1
Checksum:i1A2CBFA5D8080E2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926080 mRNA. Translation: CAI29707.1.
RefSeqiNP_001127113.1. NM_001133641.1.

Genome annotation databases

EnsembliENSPPYT00000003945; ENSPPYP00000003798; ENSPPYG00000003310.
GeneIDi100174154.
KEGGipon:100174154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR926080 mRNA. Translation: CAI29707.1 .
RefSeqi NP_001127113.1. NM_001133641.1.

3D structure databases

ProteinModelPortali Q5NVF6.
SMRi Q5NVF6. Positions 31-371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000003945 ; ENSPPYP00000003798 ; ENSPPYG00000003310 .
GeneIDi 100174154.
KEGGi pon:100174154.

Organism-specific databases

CTDi 53.

Phylogenomic databases

GeneTreei ENSGT00530000062956.
HOGENOMi HOG000231439.
HOVERGENi HBG002203.
InParanoidi Q5NVF6.
KOi K14410.
OMAi QDFLHLT.
OrthoDBi EOG7GXPBJ.
TreeFami TF312893.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPPAL_PONAB
AccessioniPrimary (citable) accession number: Q5NVF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: January 4, 2005
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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