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Q5NU32

- AOFA_HORSE

UniProt

Q5NU32 - AOFA_HORSE

Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.By similarity

    Catalytic activityi

    RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

    Cofactori

    FAD.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei335 – 3351Important for substrate specificityBy similarity
    Sitei374 – 3741Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    GO - Biological processi

    1. dopamine catabolic process Source: Ensembl
    2. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Catecholamine metabolism, Neurotransmitter degradation

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] A (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase type A
    Short name:
    MAO-A
    Gene namesi
    Name:MAOA
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Chromosome X

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099849Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9796.ENSECAP00000020478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NU32.
    SMRiQ5NU32. Positions 12-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 497497CytoplasmicBy similarityAdd
    BLAST
    Topological domaini519 – 5279Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1231.
    GeneTreeiENSGT00730000110903.
    HOGENOMiHOG000221615.
    HOVERGENiHBG004255.
    InParanoidiQ5NU32.
    KOiK00274.
    OMAiGCMLIED.
    OrthoDBiEOG7K6PTP.
    TreeFamiTF313314.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    Q5NU32-1 [UniParc]FASTAAdd to Basket

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    MASQEKASMA GHMFDVVVIG GGISGLSAAK LLAEHETNVL VLEARDRVGG    50
    RTYTVRNKHV NYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY 100
    VKGKSYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE 150
    EWDKMTMKDL IDKICWTKTA RQFASLFVNI NVTSEPHQVS ALWFLWYVKQ 200
    CGGTTRIFSI TNGGQERKFV GGSGQVSERI MELLGDRVKL EHPVTYVDQS 250
    GDNIIVETLN HEHFECKYVI SAIPPALTAK IHFKPELPSE RNQLIQRLPM 300
    GAIIKCMMYY KEAFWKKKDY CGSMIIEDEE APISITLDDS KPDGSLPAIM 350
    GFILARKADR LAKLHKEMRK KKICELYAKV LGSQEALQPV HYEEKNWCEE 400
    QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATR WSGYMEGAVE 450
    AGERAAREIL NALGKVAEKD IWLQEPESKD VPAVEITHSF WERNLPSVGG 500
    LLKIIGFSTS ITALWIVVYK FKLLTRS 527
    Length:527
    Mass (Da):59,580
    Last modified:February 1, 2005 - v1
    Checksum:i177988F29564E35B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB178282 mRNA. Translation: BAD80721.1.
    RefSeqiNP_001075301.1. NM_001081832.1.
    UniGeneiEca.12721.

    Genome annotation databases

    EnsembliENSECAT00000024641; ENSECAP00000020478; ENSECAG00000022277.
    GeneIDi100033867.
    KEGGiecb:100033867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB178282 mRNA. Translation: BAD80721.1 .
    RefSeqi NP_001075301.1. NM_001081832.1.
    UniGenei Eca.12721.

    3D structure databases

    ProteinModelPortali Q5NU32.
    SMRi Q5NU32. Positions 12-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9796.ENSECAP00000020478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSECAT00000024641 ; ENSECAP00000020478 ; ENSECAG00000022277 .
    GeneIDi 100033867.
    KEGGi ecb:100033867.

    Organism-specific databases

    CTDi 4128.

    Phylogenomic databases

    eggNOGi COG1231.
    GeneTreei ENSGT00730000110903.
    HOGENOMi HOG000221615.
    HOVERGENi HBG004255.
    InParanoidi Q5NU32.
    KOi K00274.
    OMAi GCMLIED.
    OrthoDBi EOG7K6PTP.
    TreeFami TF313314.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. "Equus caballus monoamine oxidase A (MAOA), mRNA."
      Momozawa Y., Mori Y.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAOFA_HORSE
    AccessioniPrimary (citable) accession number: Q5NU32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3