Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei335Important for substrate specificityBy similarity1
Sitei374Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 497CytoplasmicBy similarityAdd BLAST497
Transmembranei498 – 518Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST21
Topological domaini519 – 527Mitochondrial intermembraneBy similarity9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000998491 – 527Amine oxidase [flavin-containing] AAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei406S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5NU32.
PeptideAtlasiQ5NU32.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020478.

Structurei

3D structure databases

ProteinModelPortaliQ5NU32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni520 – 522Interaction with membrane phospholipid headgroupsBy similarity3

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiQ5NU32.
KOiK00274.
OMAiDAPWEAP.
OrthoDBiEOG091G0G7P.
TreeFamiTF313314.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5NU32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQEKASMA GHMFDVVVIG GGISGLSAAK LLAEHETNVL VLEARDRVGG
60 70 80 90 100
RTYTVRNKHV NYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY
110 120 130 140 150
VKGKSYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE
160 170 180 190 200
EWDKMTMKDL IDKICWTKTA RQFASLFVNI NVTSEPHQVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSI TNGGQERKFV GGSGQVSERI MELLGDRVKL EHPVTYVDQS
260 270 280 290 300
GDNIIVETLN HEHFECKYVI SAIPPALTAK IHFKPELPSE RNQLIQRLPM
310 320 330 340 350
GAIIKCMMYY KEAFWKKKDY CGSMIIEDEE APISITLDDS KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKLHKEMRK KKICELYAKV LGSQEALQPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATR WSGYMEGAVE
460 470 480 490 500
AGERAAREIL NALGKVAEKD IWLQEPESKD VPAVEITHSF WERNLPSVGG
510 520
LLKIIGFSTS ITALWIVVYK FKLLTRS
Length:527
Mass (Da):59,580
Last modified:February 1, 2005 - v1
Checksum:i177988F29564E35B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB178282 mRNA. Translation: BAD80721.1.
RefSeqiNP_001075301.1. NM_001081832.1.
UniGeneiEca.12721.

Genome annotation databases

EnsembliENSECAT00000024641; ENSECAP00000020478; ENSECAG00000022277.
GeneIDi100033867.
KEGGiecb:100033867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB178282 mRNA. Translation: BAD80721.1.
RefSeqiNP_001075301.1. NM_001081832.1.
UniGeneiEca.12721.

3D structure databases

ProteinModelPortaliQ5NU32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020478.

Proteomic databases

PaxDbiQ5NU32.
PeptideAtlasiQ5NU32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000024641; ENSECAP00000020478; ENSECAG00000022277.
GeneIDi100033867.
KEGGiecb:100033867.

Organism-specific databases

CTDi4128.

Phylogenomic databases

eggNOGiKOG0029. Eukaryota.
ENOG410XSNC. LUCA.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiQ5NU32.
KOiK00274.
OMAiDAPWEAP.
OrthoDBiEOG091G0G7P.
TreeFamiTF313314.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAOFA_HORSE
AccessioniPrimary (citable) accession number: Q5NU32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: October 5, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.