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Q5NU32

- AOFA_HORSE

UniProt

Q5NU32 - AOFA_HORSE

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Protein
Amine oxidase [flavin-containing] A
Gene
MAOA
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificity By similarity
Sitei374 – 3741Important for catalytic activity By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. dopamine catabolic process Source: Ensembl
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497Cytoplasmic By similarity
Add
BLAST
Transmembranei498 – 51821Helical; Anchor for type IV membrane protein; By similarity
Add
BLAST
Topological domaini519 – 5279Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] A
PRO_0000099849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei406 – 4061S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020478.

Structurei

3D structure databases

ProteinModelPortaliQ5NU32.
SMRiQ5NU32. Positions 12-524.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiQ5NU32.
KOiK00274.
OMAiGCMLIED.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Q5NU32-1 [UniParc]FASTAAdd to Basket

« Hide

MASQEKASMA GHMFDVVVIG GGISGLSAAK LLAEHETNVL VLEARDRVGG    50
RTYTVRNKHV NYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY 100
VKGKSYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE 150
EWDKMTMKDL IDKICWTKTA RQFASLFVNI NVTSEPHQVS ALWFLWYVKQ 200
CGGTTRIFSI TNGGQERKFV GGSGQVSERI MELLGDRVKL EHPVTYVDQS 250
GDNIIVETLN HEHFECKYVI SAIPPALTAK IHFKPELPSE RNQLIQRLPM 300
GAIIKCMMYY KEAFWKKKDY CGSMIIEDEE APISITLDDS KPDGSLPAIM 350
GFILARKADR LAKLHKEMRK KKICELYAKV LGSQEALQPV HYEEKNWCEE 400
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATR WSGYMEGAVE 450
AGERAAREIL NALGKVAEKD IWLQEPESKD VPAVEITHSF WERNLPSVGG 500
LLKIIGFSTS ITALWIVVYK FKLLTRS 527
Length:527
Mass (Da):59,580
Last modified:February 1, 2005 - v1
Checksum:i177988F29564E35B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB178282 mRNA. Translation: BAD80721.1.
RefSeqiNP_001075301.1. NM_001081832.1.
UniGeneiEca.12721.

Genome annotation databases

EnsembliENSECAT00000024641; ENSECAP00000020478; ENSECAG00000022277.
GeneIDi100033867.
KEGGiecb:100033867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB178282 mRNA. Translation: BAD80721.1 .
RefSeqi NP_001075301.1. NM_001081832.1.
UniGenei Eca.12721.

3D structure databases

ProteinModelPortali Q5NU32.
SMRi Q5NU32. Positions 12-524.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000020478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000024641 ; ENSECAP00000020478 ; ENSECAG00000022277 .
GeneIDi 100033867.
KEGGi ecb:100033867.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi Q5NU32.
KOi K00274.
OMAi GCMLIED.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Equus caballus monoamine oxidase A (MAOA), mRNA."
    Momozawa Y., Mori Y.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAOFA_HORSE
AccessioniPrimary (citable) accession number: Q5NU32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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