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Q5NU32

- AOFA_HORSE

UniProt

Q5NU32 - AOFA_HORSE

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Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificityBy similarity
Sitei374 – 3741Important for catalytic activityBy similarity

GO - Molecular functioni

  1. primary amine oxidase activity Source: Ensembl

GO - Biological processi

  1. dopamine catabolic process Source: Ensembl
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497CytoplasmicBy similarityAdd
BLAST
Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
BLAST
Topological domaini519 – 5279Mitochondrial intermembraneBy similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020478.

Structurei

3D structure databases

ProteinModelPortaliQ5NU32.
SMRiQ5NU32. Positions 12-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiQ5NU32.
KOiK00274.
OMAiGCMLIED.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Q5NU32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASQEKASMA GHMFDVVVIG GGISGLSAAK LLAEHETNVL VLEARDRVGG
60 70 80 90 100
RTYTVRNKHV NYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY
110 120 130 140 150
VKGKSYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE
160 170 180 190 200
EWDKMTMKDL IDKICWTKTA RQFASLFVNI NVTSEPHQVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSI TNGGQERKFV GGSGQVSERI MELLGDRVKL EHPVTYVDQS
260 270 280 290 300
GDNIIVETLN HEHFECKYVI SAIPPALTAK IHFKPELPSE RNQLIQRLPM
310 320 330 340 350
GAIIKCMMYY KEAFWKKKDY CGSMIIEDEE APISITLDDS KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKLHKEMRK KKICELYAKV LGSQEALQPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATR WSGYMEGAVE
460 470 480 490 500
AGERAAREIL NALGKVAEKD IWLQEPESKD VPAVEITHSF WERNLPSVGG
510 520
LLKIIGFSTS ITALWIVVYK FKLLTRS
Length:527
Mass (Da):59,580
Last modified:February 1, 2005 - v1
Checksum:i177988F29564E35B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB178282 mRNA. Translation: BAD80721.1.
RefSeqiNP_001075301.1. NM_001081832.1.
UniGeneiEca.12721.

Genome annotation databases

EnsembliENSECAT00000024641; ENSECAP00000020478; ENSECAG00000022277.
GeneIDi100033867.
KEGGiecb:100033867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB178282 mRNA. Translation: BAD80721.1 .
RefSeqi NP_001075301.1. NM_001081832.1.
UniGenei Eca.12721.

3D structure databases

ProteinModelPortali Q5NU32.
SMRi Q5NU32. Positions 12-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000020478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000024641 ; ENSECAP00000020478 ; ENSECAG00000022277 .
GeneIDi 100033867.
KEGGi ecb:100033867.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi Q5NU32.
KOi K00274.
OMAi GCMLIED.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Equus caballus monoamine oxidase A (MAOA), mRNA."
    Momozawa Y., Mori Y.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAOFA_HORSE
AccessioniPrimary (citable) accession number: Q5NU32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3