Coagulation factor XI precursor - Bos taurus (Bovine)

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Q5NTB3 (FA11_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 61. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Coagulation factor XI
Short name=FXI
EC=3.4.21.27

Alternative name(s):
Plasma thromboplastin antecedent
Short name=PTA

Gene names

Name:

F11

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	625 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX By similarity.
Catalytic activity	Selective cleavage of Arg-\|-Ala and Arg-\|-Val bonds in factor IX to form factor IXa.
Enzyme regulation	Inhibited by SERPINA5 By similarity.
Subunit structure	Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond By similarity.
Subcellular location	Secreted By similarity.
Post-translational modification	Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen By similarity.
Involvement in disease	Defects in F11 are the cause of factor XI deficiency in Japanese black cattle. It is a hereditary mild bleeding disorder with an autosomal recessive mode of inheritance.
Sequence similarities	Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 4 apple domains. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Biological process	Blood coagulation Hemostasis
Cellular component	Secreted
Disease	Disease mutation
Domain	Repeat Signal
Ligand	Heparin-binding
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heparin binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

By similarity

Chain

19 – 387

369

Coagulation factor XIa heavy chain By similarity

PRO_0000244565

Chain

388 – 625

238

Coagulation factor XIa light chain By similarity

PRO_0000244566

Regions

Domain

20 – 103

Apple 1

Domain

110 – 193

Apple 2

Domain

200 – 283

Apple 3

Domain

291 – 374

Apple 4

Domain

388 – 623

236

Peptidase S1

Region

547 – 550

Heparin-binding By similarity

Sites

Active site

431

Charge relay system By similarity

Active site

480

Charge relay system By similarity

Active site

575

Charge relay system By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

126

N-linked (GlcNAc...) Potential

Glycosylation

450

N-linked (GlcNAc...) Potential

Glycosylation

491

N-linked (GlcNAc...) Potential

Disulfide bond

20 ↔ 103

Potential

Disulfide bond

Interchain By similarity

Disulfide bond

46 ↔ 76

By similarity

Disulfide bond

50 ↔ 56

By similarity

Disulfide bond

110 ↔ 193

By similarity

Disulfide bond

136 ↔ 165

By similarity

Disulfide bond

140 ↔ 146

By similarity

Disulfide bond

200 ↔ 283

By similarity

Disulfide bond

226 ↔ 255

By similarity

Disulfide bond

230 ↔ 236

By similarity

Disulfide bond

291 ↔ 374

By similarity

Disulfide bond

317 ↔ 346

By similarity

Disulfide bond

321 ↔ 327

By similarity

Disulfide bond

339

Interchain Potential

Disulfide bond

380 ↔ 500

Interchain (between heavy and light chains) By similarity

Disulfide bond

416 ↔ 432

By similarity

Disulfide bond

514 ↔ 581

Potential

Disulfide bond

545 ↔ 560

By similarity

Disulfide bond

571 ↔ 599

Potential

Natural variations

Natural variant

290

F → LYVQNI in factor XI deficiency.

Sequences

Sequence

Length

Mass (Da)

Tools

Q5NTB3 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: B4F10BCC7CA7B972
Show »

FASTA

625

69,872

        10         20         30         40         50         60 
MTLLYQMVHF ALFASVAGEC VTTLFQDACF KGGDITVAFA PNAKHCQIIC THHPRCLLFT 

        70         80         90        100        110        120 
FMTESSSEDP TKWYTCILKD SVTETLPMVN MTGAISGYSS KQCLHHISAC SKDMYVDLNM 

       130        140        150        160        170        180 
KGMNYNSSLA QSARECQQRC TDDTHCHFFT FATRHFPSIK DRNTCLLKNT QTGTPTSITK 

       190        200        210        220        230        240 
LHEVVSGFSL KSCGLSNLAC IRDIFPRTAF VDITIDTVMA PDPFVCRSIC THHPSCLFFT 

       250        260        270        280        290        300 
FLSEEWPTAS ERNLCLLKTS SSGLPSARFR KNRAFSGFSL QHCQHSVPVF CHSSFYRNTD 

       310        320        330        340        350        360 
FLGEELDIVD ADSHEACQKT CTNSIRCQFF TYSPSQESCN GGKGKCYLKL SANGSPTKIL 

       370        380        390        400        410        420 
HGTGSISGYT LRLCKMDNVC TTKIKTRIVG GTQSVHGEWP WQITLHVTSP TQRHLCGGAI 

       430        440        450        460        470        480 
IGNQWILTAA HCFNEVKSPN VLRVYSGILN QSEIKEDTSF FGVQEIIIHD QYEKAESGYD 

       490        500        510        520        530        540 
IALLKLETAM NYTDSQWPIC LPSKGDRNVM YTECWVTGWG YRKLRDKIQN TLQKAKVPLM 

       550        560        570        580        590        600 
TNEECQAGYR EHRITSKMVC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCG 

       610        620 
QRERPGVYSN VVEYVDWILE KTQGP

« Hide

References

[1]

"An insertion mutation of the bovine F11 gene is responsible for factor XI deficiency in Japanese black cattle."
Kunieda M., Tsuji T., Abbasi A.R., Khalaj M., Ikeda M., Miyadera K., Ogawa H., Kunieda T.
Mamm. Genome 16:383-389(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT FACTOR XI DEFICIENCY 290-LEU-TYR-VAL-GLN-ASN-ILE INS DEL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB196307 mRNA. Translation: BAD77921.1. AB196308 Genomic DNA. Translation: BAD77922.1.
IPI	IPI00696841.
RefSeq	NP_001008665.1. NM_001008665.1.
UniGene	Bt.29971.
3D structure databases
ProteinModelPortal	Q5NTB3.
SMR	Q5NTB3. Positions 20-622.
ModBase	Search...
Protein family/group databases
MEROPS	S01.213.
Proteomic databases
PRIDE	Q5NTB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	407998.
KEGG	bta:407998.
Organism-specific databases
CTD	2160.
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000112467.
HOVERGEN	HBG000399.
InParanoid	Q5NTB3.
KO	K01323.
OrthoDB	EOG4FFD18.
Family and domain databases
InterPro	IPR000177. Apple. IPR003014. PAN-1_domain. IPR003609. Pan_app. IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00024. PAN_1. 4 hits. PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00005. APPLEDOMAIN. PR00722. CHYMOTRYPSIN.
SMART	SM00223. APPLE. 4 hits. SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS00495. APPLE. 2 hits. PS50948. PAN. 4 hits. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20818619.

Entry information

Entry name

FA11_BOVIN

Accession

Primary (citable) accession number: Q5NTB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Cleaved into the following 2 chains:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents