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Q5NTB3

- FA11_BOVIN

UniProt

Q5NTB3 - FA11_BOVIN

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Protein

Coagulation factor XI

Gene
F11
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX By similarity.

Catalytic activityi

Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

Enzyme regulationi

Inhibited by SERPINA5 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei431 – 4311Charge relay system By similarity
Active sitei480 – 4801Charge relay system By similarity
Active sitei575 – 5751Charge relay system By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiS01.213.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XI (EC:3.4.21.27)
Short name:
FXI
Alternative name(s):
Plasma thromboplastin antecedent
Short name:
PTA
Cleaved into the following 2 chains:
Gene namesi
Name:F11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in F11 are the cause of factor XI deficiency in Japanese black cattle. It is a hereditary mild bleeding disorder with an autosomal recessive mode of inheritance.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarityAdd
BLAST
Chaini19 – 387369Coagulation factor XIa heavy chain By similarityPRO_0000244565Add
BLAST
Chaini388 – 625238Coagulation factor XIa light chain By similarityPRO_0000244566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 103 Reviewed prediction
Disulfide bondi29 – 29Interchain By similarity
Disulfide bondi46 ↔ 76 By similarity
Disulfide bondi50 ↔ 56 By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 193 By similarity
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi136 ↔ 165 By similarity
Disulfide bondi140 ↔ 146 By similarity
Disulfide bondi200 ↔ 283 By similarity
Disulfide bondi226 ↔ 255 By similarity
Disulfide bondi230 ↔ 236 By similarity
Disulfide bondi291 ↔ 374 By similarity
Disulfide bondi317 ↔ 346 By similarity
Disulfide bondi321 ↔ 327 By similarity
Disulfide bondi339 – 339Interchain Reviewed prediction
Disulfide bondi380 ↔ 500Interchain (between heavy and light chains) By similarity
Disulfide bondi416 ↔ 432 By similarity
Glycosylationi450 – 4501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi514 ↔ 581 By similarity
Disulfide bondi545 ↔ 560 By similarity
Disulfide bondi571 ↔ 599 By similarity

Post-translational modificationi

Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5NTB3.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5NTB3.
SMRiQ5NTB3. Positions 20-622.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 10384Apple 1Add
BLAST
Domaini110 – 19384Apple 2Add
BLAST
Domaini200 – 28384Apple 3Add
BLAST
Domaini291 – 37484Apple 4Add
BLAST
Domaini388 – 623236Peptidase S1Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni547 – 5504Heparin-binding By similarity

Sequence similaritiesi

Contains 4 apple domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000112467.
HOVERGENiHBG000399.
InParanoidiQ5NTB3.
KOiK01323.

Family and domain databases

InterProiIPR000177. Apple.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTiSM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00495. APPLE. 2 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NTB3-1 [UniParc]FASTAAdd to Basket

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MTLLYQMVHF ALFASVAGEC VTTLFQDACF KGGDITVAFA PNAKHCQIIC    50
THHPRCLLFT FMTESSSEDP TKWYTCILKD SVTETLPMVN MTGAISGYSS 100
KQCLHHISAC SKDMYVDLNM KGMNYNSSLA QSARECQQRC TDDTHCHFFT 150
FATRHFPSIK DRNTCLLKNT QTGTPTSITK LHEVVSGFSL KSCGLSNLAC 200
IRDIFPRTAF VDITIDTVMA PDPFVCRSIC THHPSCLFFT FLSEEWPTAS 250
ERNLCLLKTS SSGLPSARFR KNRAFSGFSL QHCQHSVPVF CHSSFYRNTD 300
FLGEELDIVD ADSHEACQKT CTNSIRCQFF TYSPSQESCN GGKGKCYLKL 350
SANGSPTKIL HGTGSISGYT LRLCKMDNVC TTKIKTRIVG GTQSVHGEWP 400
WQITLHVTSP TQRHLCGGAI IGNQWILTAA HCFNEVKSPN VLRVYSGILN 450
QSEIKEDTSF FGVQEIIIHD QYEKAESGYD IALLKLETAM NYTDSQWPIC 500
LPSKGDRNVM YTECWVTGWG YRKLRDKIQN TLQKAKVPLM TNEECQAGYR 550
EHRITSKMVC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCG 600
QRERPGVYSN VVEYVDWILE KTQGP 625
Length:625
Mass (Da):69,872
Last modified:February 1, 2005 - v1
Checksum:iB4F10BCC7CA7B972
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti290 – 2901F → LYVQNI in factor XI deficiency.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB196307 mRNA. Translation: BAD77921.1.
AB196308 Genomic DNA. Translation: BAD77922.1.
RefSeqiNP_001008665.1. NM_001008665.1.
UniGeneiBt.29971.

Genome annotation databases

GeneIDi407998.
KEGGibta:407998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB196307 mRNA. Translation: BAD77921.1 .
AB196308 Genomic DNA. Translation: BAD77922.1 .
RefSeqi NP_001008665.1. NM_001008665.1.
UniGenei Bt.29971.

3D structure databases

ProteinModelPortali Q5NTB3.
SMRi Q5NTB3. Positions 20-622.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.213.

Proteomic databases

PRIDEi Q5NTB3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 407998.
KEGGi bta:407998.

Organism-specific databases

CTDi 2160.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000112467.
HOVERGENi HBG000399.
InParanoidi Q5NTB3.
KOi K01323.

Miscellaneous databases

NextBioi 20818619.

Family and domain databases

InterProi IPR000177. Apple.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTi SM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS00495. APPLE. 2 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An insertion mutation of the bovine F11 gene is responsible for factor XI deficiency in Japanese black cattle."
    Kunieda M., Tsuji T., Abbasi A.R., Khalaj M., Ikeda M., Miyadera K., Ogawa H., Kunieda T.
    Mamm. Genome 16:383-389(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT FACTOR XI DEFICIENCY 290-LEU-TYR-VAL-GLN-ASN-ILE INS DEL.

Entry informationi

Entry nameiFA11_BOVIN
AccessioniPrimary (citable) accession number: Q5NTB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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