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Q5NTB3 (FA11_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coagulation factor XI

Short name=FXI
EC=3.4.21.27
Alternative name(s):
Plasma thromboplastin antecedent
Short name=PTA
Gene names
Name:F11
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX By similarity.

Catalytic activity

Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

Enzyme regulation

Inhibited by SERPINA5 By similarity.

Subunit structure

Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond By similarity.

Subcellular location

Secreted By similarity.

Post-translational modification

Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen By similarity.

Involvement in disease

Defects in F11 are the cause of factor XI deficiency in Japanese black cattle. It is a hereditary mild bleeding disorder with an autosomal recessive mode of inheritance.

Sequence similarities

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.

Contains 4 apple domains.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processBlood coagulation
Hemostasis
   Cellular componentSecreted
   DiseaseDisease mutation
   DomainRepeat
Signal
   LigandHeparin-binding
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 387369Coagulation factor XIa heavy chain By similarity
PRO_0000244565
Chain388 – 625238Coagulation factor XIa light chain By similarity
PRO_0000244566

Regions

Domain20 – 10384Apple 1
Domain110 – 19384Apple 2
Domain200 – 28384Apple 3
Domain291 – 37484Apple 4
Domain388 – 623236Peptidase S1
Region547 – 5504Heparin-binding By similarity

Sites

Active site4311Charge relay system By similarity
Active site4801Charge relay system By similarity
Active site5751Charge relay system By similarity

Amino acid modifications

Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation4501N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Disulfide bond20 ↔ 103 Potential
Disulfide bond29Interchain By similarity
Disulfide bond46 ↔ 76 By similarity
Disulfide bond50 ↔ 56 By similarity
Disulfide bond110 ↔ 193 By similarity
Disulfide bond136 ↔ 165 By similarity
Disulfide bond140 ↔ 146 By similarity
Disulfide bond200 ↔ 283 By similarity
Disulfide bond226 ↔ 255 By similarity
Disulfide bond230 ↔ 236 By similarity
Disulfide bond291 ↔ 374 By similarity
Disulfide bond317 ↔ 346 By similarity
Disulfide bond321 ↔ 327 By similarity
Disulfide bond339Interchain Potential
Disulfide bond380 ↔ 500Interchain (between heavy and light chains) By similarity
Disulfide bond416 ↔ 432 By similarity
Disulfide bond514 ↔ 581 By similarity
Disulfide bond545 ↔ 560 By similarity
Disulfide bond571 ↔ 599 By similarity

Natural variations

Natural variant2901F → LYVQNI in factor XI deficiency.

Sequences

Sequence LengthMass (Da)Tools
Q5NTB3 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: B4F10BCC7CA7B972

FASTA62569,872
        10         20         30         40         50         60 
MTLLYQMVHF ALFASVAGEC VTTLFQDACF KGGDITVAFA PNAKHCQIIC THHPRCLLFT 

        70         80         90        100        110        120 
FMTESSSEDP TKWYTCILKD SVTETLPMVN MTGAISGYSS KQCLHHISAC SKDMYVDLNM 

       130        140        150        160        170        180 
KGMNYNSSLA QSARECQQRC TDDTHCHFFT FATRHFPSIK DRNTCLLKNT QTGTPTSITK 

       190        200        210        220        230        240 
LHEVVSGFSL KSCGLSNLAC IRDIFPRTAF VDITIDTVMA PDPFVCRSIC THHPSCLFFT 

       250        260        270        280        290        300 
FLSEEWPTAS ERNLCLLKTS SSGLPSARFR KNRAFSGFSL QHCQHSVPVF CHSSFYRNTD 

       310        320        330        340        350        360 
FLGEELDIVD ADSHEACQKT CTNSIRCQFF TYSPSQESCN GGKGKCYLKL SANGSPTKIL 

       370        380        390        400        410        420 
HGTGSISGYT LRLCKMDNVC TTKIKTRIVG GTQSVHGEWP WQITLHVTSP TQRHLCGGAI 

       430        440        450        460        470        480 
IGNQWILTAA HCFNEVKSPN VLRVYSGILN QSEIKEDTSF FGVQEIIIHD QYEKAESGYD 

       490        500        510        520        530        540 
IALLKLETAM NYTDSQWPIC LPSKGDRNVM YTECWVTGWG YRKLRDKIQN TLQKAKVPLM 

       550        560        570        580        590        600 
TNEECQAGYR EHRITSKMVC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCG 

       610        620 
QRERPGVYSN VVEYVDWILE KTQGP 

« Hide

References

[1]"An insertion mutation of the bovine F11 gene is responsible for factor XI deficiency in Japanese black cattle."
Kunieda M., Tsuji T., Abbasi A.R., Khalaj M., Ikeda M., Miyadera K., Ogawa H., Kunieda T.
Mamm. Genome 16:383-389(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT FACTOR XI DEFICIENCY 290-LEU-TYR-VAL-GLN-ASN-ILE INS DEL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB196307 mRNA. Translation: BAD77921.1.
AB196308 Genomic DNA. Translation: BAD77922.1.
RefSeqNP_001008665.1. NM_001008665.1.
UniGeneBt.29971.

3D structure databases

ProteinModelPortalQ5NTB3.
SMRQ5NTB3. Positions 20-622.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.213.

Proteomic databases

PRIDEQ5NTB3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID407998.
KEGGbta:407998.

Organism-specific databases

CTD2160.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000112467.
HOVERGENHBG000399.
InParanoidQ5NTB3.
KOK01323.

Family and domain databases

InterProIPR000177. Apple.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTSM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS00495. APPLE. 2 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818619.

Entry information

Entry nameFA11_BOVIN
AccessionPrimary (citable) accession number: Q5NTB3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: January 22, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries