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Q5NTB3

- FA11_BOVIN

UniProt

Q5NTB3 - FA11_BOVIN

Protein

Coagulation factor XI

Gene

F11

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.By similarity

    Catalytic activityi

    Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

    Enzyme regulationi

    Inhibited by SERPINA5.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei431 – 4311Charge relay systemBy similarity
    Active sitei480 – 4801Charge relay systemBy similarity
    Active sitei575 – 5751Charge relay systemBy similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiS01.213.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coagulation factor XI (EC:3.4.21.27)
    Short name:
    FXI
    Alternative name(s):
    Plasma thromboplastin antecedent
    Short name:
    PTA
    Cleaved into the following 2 chains:
    Gene namesi
    Name:F11
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Defects in F11 are the cause of factor XI deficiency in Japanese black cattle. It is a hereditary mild bleeding disorder with an autosomal recessive mode of inheritance.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 387369Coagulation factor XIa heavy chainBy similarityPRO_0000244565Add
    BLAST
    Chaini388 – 625238Coagulation factor XIa light chainBy similarityPRO_0000244566Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 103Sequence Analysis
    Disulfide bondi29 – 29InterchainBy similarity
    Disulfide bondi46 ↔ 76By similarity
    Disulfide bondi50 ↔ 56By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 193By similarity
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 165By similarity
    Disulfide bondi140 ↔ 146By similarity
    Disulfide bondi200 ↔ 283By similarity
    Disulfide bondi226 ↔ 255By similarity
    Disulfide bondi230 ↔ 236By similarity
    Disulfide bondi291 ↔ 374By similarity
    Disulfide bondi317 ↔ 346By similarity
    Disulfide bondi321 ↔ 327By similarity
    Disulfide bondi339 – 339InterchainSequence Analysis
    Disulfide bondi380 ↔ 500Interchain (between heavy and light chains)PROSITE-ProRule annotation
    Disulfide bondi416 ↔ 432By similarity
    Glycosylationi450 – 4501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi514 ↔ 581By similarity
    Disulfide bondi545 ↔ 560By similarity
    Disulfide bondi571 ↔ 599By similarity

    Post-translational modificationi

    Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ5NTB3.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NTB3.
    SMRiQ5NTB3. Positions 20-622.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 10384Apple 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini110 – 19384Apple 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini200 – 28384Apple 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini291 – 37484Apple 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini388 – 623236Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni547 – 5504Heparin-bindingBy similarity

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation
    Contains 4 apple domains.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000112467.
    HOVERGENiHBG000399.
    InParanoidiQ5NTB3.
    KOiK01323.

    Family and domain databases

    InterProiIPR000177. Apple.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00024. PAN_1. 4 hits.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00005. APPLEDOMAIN.
    PR00722. CHYMOTRYPSIN.
    SMARTiSM00223. APPLE. 4 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS00495. APPLE. 2 hits.
    PS50948. PAN. 4 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NTB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLLYQMVHF ALFASVAGEC VTTLFQDACF KGGDITVAFA PNAKHCQIIC    50
    THHPRCLLFT FMTESSSEDP TKWYTCILKD SVTETLPMVN MTGAISGYSS 100
    KQCLHHISAC SKDMYVDLNM KGMNYNSSLA QSARECQQRC TDDTHCHFFT 150
    FATRHFPSIK DRNTCLLKNT QTGTPTSITK LHEVVSGFSL KSCGLSNLAC 200
    IRDIFPRTAF VDITIDTVMA PDPFVCRSIC THHPSCLFFT FLSEEWPTAS 250
    ERNLCLLKTS SSGLPSARFR KNRAFSGFSL QHCQHSVPVF CHSSFYRNTD 300
    FLGEELDIVD ADSHEACQKT CTNSIRCQFF TYSPSQESCN GGKGKCYLKL 350
    SANGSPTKIL HGTGSISGYT LRLCKMDNVC TTKIKTRIVG GTQSVHGEWP 400
    WQITLHVTSP TQRHLCGGAI IGNQWILTAA HCFNEVKSPN VLRVYSGILN 450
    QSEIKEDTSF FGVQEIIIHD QYEKAESGYD IALLKLETAM NYTDSQWPIC 500
    LPSKGDRNVM YTECWVTGWG YRKLRDKIQN TLQKAKVPLM TNEECQAGYR 550
    EHRITSKMVC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCG 600
    QRERPGVYSN VVEYVDWILE KTQGP 625
    Length:625
    Mass (Da):69,872
    Last modified:February 1, 2005 - v1
    Checksum:iB4F10BCC7CA7B972
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti290 – 2901F → LYVQNI in factor XI deficiency.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB196307 mRNA. Translation: BAD77921.1.
    AB196308 Genomic DNA. Translation: BAD77922.1.
    RefSeqiNP_001008665.1. NM_001008665.1.
    UniGeneiBt.29971.

    Genome annotation databases

    GeneIDi407998.
    KEGGibta:407998.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB196307 mRNA. Translation: BAD77921.1 .
    AB196308 Genomic DNA. Translation: BAD77922.1 .
    RefSeqi NP_001008665.1. NM_001008665.1.
    UniGenei Bt.29971.

    3D structure databases

    ProteinModelPortali Q5NTB3.
    SMRi Q5NTB3. Positions 20-622.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.213.

    Proteomic databases

    PRIDEi Q5NTB3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 407998.
    KEGGi bta:407998.

    Organism-specific databases

    CTDi 2160.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000112467.
    HOVERGENi HBG000399.
    InParanoidi Q5NTB3.
    KOi K01323.

    Miscellaneous databases

    NextBioi 20818619.

    Family and domain databases

    InterProi IPR000177. Apple.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00024. PAN_1. 4 hits.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00005. APPLEDOMAIN.
    PR00722. CHYMOTRYPSIN.
    SMARTi SM00223. APPLE. 4 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS00495. APPLE. 2 hits.
    PS50948. PAN. 4 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An insertion mutation of the bovine F11 gene is responsible for factor XI deficiency in Japanese black cattle."
      Kunieda M., Tsuji T., Abbasi A.R., Khalaj M., Ikeda M., Miyadera K., Ogawa H., Kunieda T.
      Mamm. Genome 16:383-389(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT FACTOR XI DEFICIENCY 290-LEU-TYR-VAL-GLN-ASN-ILE INS DEL.

    Entry informationi

    Entry nameiFA11_BOVIN
    AccessioniPrimary (citable) accession number: Q5NTB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3