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Protein

Homeobox protein DBX1

Gene

Dbx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi181 – 240HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene namesi
Name:Dbx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308896 Dbx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028441 – 335Homeobox protein DBX1Add BLAST335

Proteomic databases

PaxDbiQ5NSW5
PRIDEiQ5NSW5

Expressioni

Inductioni

By Pax6.1 Publication

Gene expression databases

BgeeiENSRNOG00000014706
GenevisibleiQ5NSW5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019739

Structurei

3D structure databases

ProteinModelPortaliQ5NSW5
SMRiQ5NSW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000112172
HOVERGENiHBG005454
InParanoidiQ5NSW5
OMAiMMFPSLI
OrthoDBiEOG091G0MGV
PhylomeDBiQ5NSW5
TreeFamiTF350735

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NSW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP
60 70 80 90 100
PTYLPRSIPT ASLSPPRQEA PTALADSGTS DLGSPGSGSR RGSSPQTALS
110 120 130 140 150
PASEPTFLKF GVNAILSSAP RRETSPALLQ SPPPKTFAFP YFEGSFQPFI
160 170 180 190 200
RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKTF
210 220 230 240 250
QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC
260 270 280 290 300
REQTLPTKLN PHPDLSDVGQ KGPGDEEEDS PGASLAYHAP PDPRHLLEGP
310 320 330
LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS
Length:335
Mass (Da):36,403
Last modified:February 1, 2005 - v1
Checksum:iECE2DCFA7BDEF690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB197138 mRNA Translation: BAD83364.1
RefSeqiNP_001009644.1, NM_001009644.1
UniGeneiRn.104881

Genome annotation databases

EnsembliENSRNOT00000019739; ENSRNOP00000019739; ENSRNOG00000014706
GeneIDi292934
KEGGirno:292934
UCSCiRGD:1308896 rat

Similar proteinsi

Entry informationi

Entry nameiDBX1_RAT
AccessioniPrimary (citable) accession number: Q5NSW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health