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Protein

Homeobox protein DBX1

Gene

Dbx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi181 – 24060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene namesi
Name:Dbx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308896. Dbx1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Homeobox protein DBX1PRO_0000302844Add
BLAST

Proteomic databases

PaxDbiQ5NSW5.
PRIDEiQ5NSW5.

Expressioni

Inductioni

By Pax6.1 Publication

Gene expression databases

GenevisibleiQ5NSW5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019739.

Structurei

3D structure databases

ProteinModelPortaliQ5NSW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000112172.
HOVERGENiHBG005454.
InParanoidiQ5NSW5.
OMAiMMFPSLI.
OrthoDBiEOG091G0MGV.
PhylomeDBiQ5NSW5.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NSW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP
60 70 80 90 100
PTYLPRSIPT ASLSPPRQEA PTALADSGTS DLGSPGSGSR RGSSPQTALS
110 120 130 140 150
PASEPTFLKF GVNAILSSAP RRETSPALLQ SPPPKTFAFP YFEGSFQPFI
160 170 180 190 200
RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKTF
210 220 230 240 250
QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC
260 270 280 290 300
REQTLPTKLN PHPDLSDVGQ KGPGDEEEDS PGASLAYHAP PDPRHLLEGP
310 320 330
LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS
Length:335
Mass (Da):36,403
Last modified:February 1, 2005 - v1
Checksum:iECE2DCFA7BDEF690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB197138 mRNA. Translation: BAD83364.1.
RefSeqiNP_001009644.1. NM_001009644.1.
UniGeneiRn.104881.

Genome annotation databases

EnsembliENSRNOT00000019739; ENSRNOP00000019739; ENSRNOG00000014706.
GeneIDi292934.
KEGGirno:292934.
UCSCiRGD:1308896. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB197138 mRNA. Translation: BAD83364.1.
RefSeqiNP_001009644.1. NM_001009644.1.
UniGeneiRn.104881.

3D structure databases

ProteinModelPortaliQ5NSW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019739.

Proteomic databases

PaxDbiQ5NSW5.
PRIDEiQ5NSW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019739; ENSRNOP00000019739; ENSRNOG00000014706.
GeneIDi292934.
KEGGirno:292934.
UCSCiRGD:1308896. rat.

Organism-specific databases

CTDi120237.
RGDi1308896. Dbx1.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000112172.
HOVERGENiHBG005454.
InParanoidiQ5NSW5.
OMAiMMFPSLI.
OrthoDBiEOG091G0MGV.
PhylomeDBiQ5NSW5.
TreeFamiTF350735.

Miscellaneous databases

PROiQ5NSW5.

Gene expression databases

GenevisibleiQ5NSW5. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBX1_RAT
AccessioniPrimary (citable) accession number: Q5NSW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.