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Q5NRP9 (EDN1_ATEAB) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-1

Short name=ET-1
Alternative name(s):
Preproendothelin-1
Short name=PPET1
Gene names
Name:EDN1
OrganismAtelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Taxonomic identifier9368 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeAtelerix

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Endothelins are endothelium-derived vasoconstrictor peptides By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionVasoactive
Vasoconstrictor
   PTMCleavage on pair of basic residues
Disulfide bond
Gene Ontology (GO)
   Biological_processregulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

vasoconstriction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 5025 By similarity
PRO_0000008043
Peptide53 – 7321Endothelin-1
PRO_0000008044
Propeptide74 – 202129 By similarity
PRO_0000008045

Regions

Region110 – 12415Endothelin-like

Sites

Site73 – 742Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond53 ↔ 67 By similarity
Disulfide bond55 ↔ 63 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5NRP9 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 7661CA9EA4BF36AC

FASTA20223,124
        10         20         30         40         50         60 
MDYFPMIFSL LFVAFHGAPE TVVLGAELST ESEQGGEQPS PSPPWRPRRS KRCSCSSLMD 

        70         80         90        100        110        120 
KECVYFCHLD IIWVNTPEHV VPYGLGSPLR SRRSLKNSFP TKAADHRNRC RCASQKDKKC 

       130        140        150        160        170        180 
WNFCQAGKGL RLQDTMEKDW NNQKKGKDCS KLGDKCIHQQ LVEGRKIRRL EAISNSIKTS 

       190        200 
FHIAKLKAEL YREKKVTHNG TH 

« Hide

References

[1]"Cloning of hedgehog preproendothelin-1 cDNA."
Uchide T.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB197700 mRNA. Translation: BAD83372.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051441.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEDN1_ATEAB
AccessionPrimary (citable) accession number: Q5NRP9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: September 21, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families