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Q5NRP8 (EDN2_ATEAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-2

Short name=ET-2
Alternative name(s):
Preproendothelin-2
Short name=PPET2
Gene names
Name:EDN2
OrganismAtelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Taxonomic identifier9368 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeAtelerix

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Endothelins are endothelium-derived vasoconstrictor peptides By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionVasoactive
Vasoconstrictor
   PTMCleavage on pair of basic residues
Disulfide bond
Gene Ontology (GO)
   Biological_processregulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

vasoconstriction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Propeptide27 – 4721 By similarity
PRO_0000008078
Peptide50 – 7021Endothelin-2
PRO_0000008079
Propeptide71 – 180110 By similarity
PRO_0000008080

Regions

Region97 – 11216Endothelin-like

Sites

Site70 – 712Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond50 ↔ 64 By similarity
Disulfide bond52 ↔ 60 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5NRP8 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 08BBC520F8CFC753

FASTA18020,382
        10         20         30         40         50         60 
MVALPTAWCS VALALLVALH EGKSQSAATS EEPPAPSARA RGSHLRLRRC SCNSWLDKEC 

        70         80         90        100        110        120 
VYFCHLDIIW VNTPGQTAPY GLGNPPRRQR RSLPRRCECY STRDSACVTF CHQKPWPKAS 

       130        140        150        160        170        180 
AVPGEGSPTD LLWTSKTRTT AGELLRRLRD IFAAKRNFTR HQQQKATREP ESSHSRWRKR 

« Hide

References

[1]"Cloning of hedgehog preproendothelin-2 cDNA."
Uchide T.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB197701 mRNA. Translation: BAD83373.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051441.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEDN2_ATEAB
AccessionPrimary (citable) accession number: Q5NRP8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families