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Protein

Endothelin-2

Gene

EDN2

Organism
Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei70 – 712Cleavage; by KELBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Gene namesi
Name:EDN2
OrganismiAtelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Taxonomic identifieri9368 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeAtelerix

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Propeptidei27 – 4721By similarityPRO_0000008078Add
BLAST
Peptidei50 – 7021Endothelin-2PRO_0000008079Add
BLAST
Propeptidei71 – 180110By similarityPRO_0000008080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 64By similarity
Disulfide bondi52 ↔ 60By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 11216Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051441.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NRP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALPTAWCS VALALLVALH EGKSQSAATS EEPPAPSARA RGSHLRLRRC
60 70 80 90 100
SCNSWLDKEC VYFCHLDIIW VNTPGQTAPY GLGNPPRRQR RSLPRRCECY
110 120 130 140 150
STRDSACVTF CHQKPWPKAS AVPGEGSPTD LLWTSKTRTT AGELLRRLRD
160 170 180
IFAAKRNFTR HQQQKATREP ESSHSRWRKR
Length:180
Mass (Da):20,382
Last modified:February 1, 2005 - v1
Checksum:i08BBC520F8CFC753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB197701 mRNA. Translation: BAD83373.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB197701 mRNA. Translation: BAD83373.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051441.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of hedgehog preproendothelin-2 cDNA."
    Uchide T.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEDN2_ATEAB
AccessioniPrimary (citable) accession number: Q5NRP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: January 7, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.