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Q5NRP8

- EDN2_ATEAB

UniProt

Q5NRP8 - EDN2_ATEAB

Protein

Endothelin-2

Gene

EDN2

Organism
Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei70 – 712Cleavage; by KELBy similarity

    GO - Biological processi

    1. regulation of vasoconstriction Source: InterPro
    2. vasoconstriction Source: UniProtKB-KW

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-2
    Short name:
    ET-2
    Alternative name(s):
    Preproendothelin-2
    Short name:
    PPET2
    Gene namesi
    Name:EDN2
    OrganismiAtelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)
    Taxonomic identifieri9368 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeAtelerix

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Propeptidei27 – 4721By similarityPRO_0000008078Add
    BLAST
    Peptidei50 – 7021Endothelin-2PRO_0000008079Add
    BLAST
    Propeptidei71 – 180110By similarityPRO_0000008080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 64By similarity
    Disulfide bondi52 ↔ 60By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 11216Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG051441.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view]
    PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NRP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVALPTAWCS VALALLVALH EGKSQSAATS EEPPAPSARA RGSHLRLRRC    50
    SCNSWLDKEC VYFCHLDIIW VNTPGQTAPY GLGNPPRRQR RSLPRRCECY 100
    STRDSACVTF CHQKPWPKAS AVPGEGSPTD LLWTSKTRTT AGELLRRLRD 150
    IFAAKRNFTR HQQQKATREP ESSHSRWRKR 180
    Length:180
    Mass (Da):20,382
    Last modified:February 1, 2005 - v1
    Checksum:i08BBC520F8CFC753
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB197701 mRNA. Translation: BAD83373.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB197701 mRNA. Translation: BAD83373.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051441.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view ]
    PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of hedgehog preproendothelin-2 cDNA."
      Uchide T.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiEDN2_ATEAB
    AccessioniPrimary (citable) accession number: Q5NRP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3