Q5NRP8 (EDN2_ATEAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin-2
Short name=ET-2

Alternative name(s):
Preproendothelin-2
Short name=PPET2

Gene names

Name:

EDN2

Organism

Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)

Taxonomic identifier

9368 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Insectivora › Erinaceidae › Erinaceinae › Atelerix

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Endothelins are endothelium-derived vasoconstrictor peptides By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Vasoactive Vasoconstrictor
PTM	Cleavage on pair of basic residues Disulfide bond
Gene Ontology (GO)
Biological_process	regulation of vasoconstriction Inferred from electronic annotation. Source: InterPro vasoconstriction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Propeptide	27 – 47	21	By similarity		PRO_0000008078
	Peptide	50 – 70	21	Endothelin-2		PRO_0000008079
	Propeptide	71 – 180	110	By similarity		PRO_0000008080
Regions
	Region	97 – 112	16	Endothelin-like
Sites
	Site	70 – 71	2	Cleavage; by KEL By similarity
Amino acid modifications
	Disulfide bond	50 ↔ 64		By similarity
	Disulfide bond	52 ↔ 60		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5NRP8 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 08BBC520F8CFC753	FASTA	180	20,382
	10 20 30 40 50 60 MVALPTAWCS VALALLVALH EGKSQSAATS EEPPAPSARA RGSHLRLRRC SCNSWLDKEC 70 80 90 100 110 120 VYFCHLDIIW VNTPGQTAPY GLGNPPRRQR RSLPRRCECY STRDSACVTF CHQKPWPKAS 130 140 150 160 170 180 AVPGEGSPTD LLWTSKTRTT AGELLRRLRD IFAAKRNFTR HQQQKATREP ESSHSRWRKR

References

[1]	"Cloning of hedgehog preproendothelin-2 cDNA." Uchide T. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB197701 mRNA. Translation: BAD83373.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG051441.
Family and domain databases
InterPro	IPR020475. Bibrotoxin/Sarafotoxin-D. IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. IPR015658. ET-2. [Graphical view]
PANTHER	PTHR13874:SF4. PTHR13874:SF4. 1 hit.
Pfam	PF00322. Endothelin. 1 hit. [Graphical view]
PRINTS	PR00365. ENDOTHELIN.
SMART	SM00272. END. 2 hits. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EDN2_ATEAB

Accession

Primary (citable) accession number: Q5NRP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 1, 2005
Last modified:	October 3, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program