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Q5NRH4

- GLMS_ZYMMO

UniProt

Q5NRH4 - GLMS_ZYMMO

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei602 – 6021For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:ZMO0056
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135420Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi264203.ZMO0056.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NRH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini283 – 422140SIS 1UniRule annotationAdd
    BLAST
    Domaini455 – 597143SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NRH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIIGIIGR EDLSERLFQG LRRLEYRGYD SAGMCTIHDG KLDRRRAEGK    50
    LDNLGRVLAN DPLPGKIGIA HTRWATHGAP TVANAHPHIA GDVAVVHNGI 100
    IENFKTLRDE LLERGHHFES ETDTEVVAHL LDEQMQAGKD PRHAVSKVLK 150
    KLRGAFALAI LFKNYPDLLI GARLGSPLVV GYGDGENYLG SDALALAPLT 200
    QKISYLEEGD WVVLTREGIE VHDIEDRIVE RPVVLSGASG LMVEKGNYRH 250
    FMQKEIFEQP VVVAQTLQSY LRPVEGQVAL PDPDFDLSQI KRVTIVACGT 300
    SYYAGMVARY WIERFARVPV EIEAASEYRY REPVMEEGGL SLFISQSGET 350
    ADTLAALRHA RAGGQKIAVV VNVPTSSMAR EADLLLPTHA GPEIGVASTK 400
    AFTCQLAVLA ALATHIARVK GQLTQQEEQD IVRHLAEAPA ALNAALAFND 450
    TIENVATAIA PARDVLYIGR GPDYPLAMEG ALKLKEISYI HAEGYAAGEM 500
    KHGPIALIDD KVPIIVLAPS GPLFEKTVSN MQEMQARGGK VILISDEKGI 550
    QEAGDNCLAT LTMPKVHPLI APIVYAIPVQ LLAYHVAVIK GTDVDQPRNL 600
    AKSVTVE 607
    Length:607
    Mass (Da):65,988
    Last modified:January 23, 2007 - v3
    Checksum:i93B10374EB57D1DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV88680.1.
    RefSeqiYP_161791.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV88680; AAV88680; ZMO0056.
    GeneIDi3187975.
    KEGGizmo:ZMO0056.
    PATRICi32565466. VBIZymMob102260_0051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV88680.1 .
    RefSeqi YP_161791.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q5NRH4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO0056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV88680 ; AAV88680 ; ZMO0056 .
    GeneIDi 3187975.
    KEGGi zmo:ZMO0056.
    PATRICi 32565466. VBIZymMob102260_0051.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiGLMS_ZYMMO
    AccessioniPrimary (citable) accession number: Q5NRH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3