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Q5NRH4

- GLMS_ZYMMO

UniProt

Q5NRH4 - GLMS_ZYMMO

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, ZMO0056
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei602 – 6021For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:ZMO0056
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135420Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264203.ZMO0056.

Structurei

3D structure databases

ProteinModelPortaliQ5NRH4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini283 – 422140SIS 1
Add
BLAST
Domaini455 – 597143SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NRH4-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIIGIIGR EDLSERLFQG LRRLEYRGYD SAGMCTIHDG KLDRRRAEGK    50
LDNLGRVLAN DPLPGKIGIA HTRWATHGAP TVANAHPHIA GDVAVVHNGI 100
IENFKTLRDE LLERGHHFES ETDTEVVAHL LDEQMQAGKD PRHAVSKVLK 150
KLRGAFALAI LFKNYPDLLI GARLGSPLVV GYGDGENYLG SDALALAPLT 200
QKISYLEEGD WVVLTREGIE VHDIEDRIVE RPVVLSGASG LMVEKGNYRH 250
FMQKEIFEQP VVVAQTLQSY LRPVEGQVAL PDPDFDLSQI KRVTIVACGT 300
SYYAGMVARY WIERFARVPV EIEAASEYRY REPVMEEGGL SLFISQSGET 350
ADTLAALRHA RAGGQKIAVV VNVPTSSMAR EADLLLPTHA GPEIGVASTK 400
AFTCQLAVLA ALATHIARVK GQLTQQEEQD IVRHLAEAPA ALNAALAFND 450
TIENVATAIA PARDVLYIGR GPDYPLAMEG ALKLKEISYI HAEGYAAGEM 500
KHGPIALIDD KVPIIVLAPS GPLFEKTVSN MQEMQARGGK VILISDEKGI 550
QEAGDNCLAT LTMPKVHPLI APIVYAIPVQ LLAYHVAVIK GTDVDQPRNL 600
AKSVTVE 607
Length:607
Mass (Da):65,988
Last modified:January 23, 2007 - v3
Checksum:i93B10374EB57D1DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV88680.1.
RefSeqiYP_161791.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV88680; AAV88680; ZMO0056.
GeneIDi3187975.
KEGGizmo:ZMO0056.
PATRICi32565466. VBIZymMob102260_0051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV88680.1 .
RefSeqi YP_161791.1. NC_006526.2.

3D structure databases

ProteinModelPortali Q5NRH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO0056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV88680 ; AAV88680 ; ZMO0056 .
GeneIDi 3187975.
KEGGi zmo:ZMO0056.
PATRICi 32565466. VBIZymMob102260_0051.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiGLMS_ZYMMO
AccessioniPrimary (citable) accession number: Q5NRH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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