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Protein

Homoserine O-acetyltransferase

Gene

metXA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metXA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151NucleophileUniRule annotation1
Binding sitei221SubstrateUniRule annotation1
Active sitei317UniRule annotation1
Active sitei350UniRule annotation1
Binding sitei351SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERizymmo-metx. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXAUniRule annotation
Ordered Locus Names:ZMO0225
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001557501 – 373Homoserine O-acetyltransferaseAdd BLAST373

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5NR05.
SMRiQ5NR05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 355AB hydrolase-1UniRule annotationAdd BLAST310

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246301.
KOiK00641.
OMAiCQGTTGP.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. MetX_acyltransf. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoser/ser_AcTrfase.
IPR034387. Homoser_AcTrfase.
PfamiView protein in Pfam
PF00561. Abhydrolase_1. 1 hit.
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NR05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNDRRFGLK RHITLPGELA LDGGSLLTGI EIAYETYGHL NADASNAILI
60 70 80 90 100
CHPLTADQFA ASDHPITGKP GWWSRMIGKG KPIDPERYCI ICSNVLGSCL
110 120 130 140 150
GSTGPSSFTP GTETPYAMNF PVITIRDMVR AQAKLLDYLG IRQLKAVIGG
160 170 180 190 200
SMGGMQALEW ASTYPDRVKS VVIIASTARH SAQNIAFHEV GRQAIMADPK
210 220 230 240 250
WRQGNYYEEK DPPVAGLAVA RMAAHITYLS ESGLTARFGR RLQSRQEKSF
260 270 280 290 300
GFDADFQIES YLRHQGIRFV ERFDANSYLY ITRATDYFDL AEEHGGKLAN
310 320 330 340 350
AFRGTKSRFC VISFDSDWLY PTSESRVIVH ALNAAGAAVS FMELSNPNGH
360 370
DSFLLDAPDL HRTVHGFLEG DRA
Length:373
Mass (Da):41,185
Last modified:February 1, 2005 - v1
Checksum:i4E3AB1050D36EC14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV88849.1.
RefSeqiWP_011240172.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV88849; AAV88849; ZMO0225.
KEGGizmo:ZMO0225.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMETXA_ZYMMO
AccessioniPrimary (citable) accession number: Q5NR05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 1, 2005
Last modified: June 7, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families