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Q5NQC7

- FTHS_ZYMMO

UniProt

Q5NQC7 - FTHS_ZYMMO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 3 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:ZMO0454
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000199412Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264203.ZMO0454.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiHDSKITK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NQC7-1 [UniParc]FASTAAdd to Basket

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    MLSDIEIARA ATLKPITEIA GRLNIPDESV LSYGHTIAKL DGEYLNSLSS    50
    KPRGKLVLVS AITPTPAGEG KTTTTVGLGD AFNRIGKKAV ICLREPSLGP 100
    CFGVKGGAAG GGYAQVVPME RINLHFTGDF HAITSAHDLL AAMIDNHVHW 150
    GNEPVMDRNS ITFRRVIDMN DRMLRNMVIG LGGKANGYPR EGGFDISVAS 200
    EVMAILCLAS DLKDLRSRLE RIIIGEDNDH NPVAAAKIKA AGAMTALLKD 250
    ALQPNLVQTL EGNPALIHGG PFANIAHGCN SLIATKAALH LGDIAITEAG 300
    FGADLGAEKF FDIKCRQANL EPDAVVLVAT IRALKMHGGV ALADLKNENI 350
    AALETGFANL ARHAENLAKF GVKTVVAINR FHSDTEAELD KLQDLCASIG 400
    LDSAVCTHFT DGGAGAEDLA RKLSAILDAP KEDSFRLLYP DEMPLWKKIE 450
    TIAKEIYRAG EVVPQGTVLK KLKSFEEQGF GDLPVCIAKT QSSFSADPKA 500
    KNAPTGHIFP IREVRLNAGA GFIVAISGNI MTMPGLPRHP AAENIDINED 550
    NEIIGLA 557
    Length:557
    Mass (Da):59,286
    Last modified:March 23, 2010 - v3
    Checksum:iBB34CF581137F09D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV89078.2.
    RefSeqiWP_011240364.1. NC_006526.2.
    YP_162189.2. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV89078; AAV89078; ZMO0454.
    GeneIDi3189047.
    KEGGizmo:ZMO0454.
    PATRICi32566232. VBIZymMob102260_0427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV89078.2 .
    RefSeqi WP_011240364.1. NC_006526.2.
    YP_162189.2. NC_006526.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO0454.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV89078 ; AAV89078 ; ZMO0454 .
    GeneIDi 3189047.
    KEGGi zmo:ZMO0454.
    PATRICi 32566232. VBIZymMob102260_0427.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi HDSKITK.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.
    2. Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiFTHS_ZYMMO
    AccessioniPrimary (citable) accession number: Q5NQC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 65 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3