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Q5NQC7 (FTHS_ZYMMO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:ZMO0454
OrganismZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) [Complete proteome] [HAMAP]
Taxonomic identifier264203 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199412

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5NQC7 [UniParc].

Last modified March 23, 2010. Version 3.
Checksum: BB34CF581137F09D

FASTA55759,286
        10         20         30         40         50         60 
MLSDIEIARA ATLKPITEIA GRLNIPDESV LSYGHTIAKL DGEYLNSLSS KPRGKLVLVS 

        70         80         90        100        110        120 
AITPTPAGEG KTTTTVGLGD AFNRIGKKAV ICLREPSLGP CFGVKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
RINLHFTGDF HAITSAHDLL AAMIDNHVHW GNEPVMDRNS ITFRRVIDMN DRMLRNMVIG 

       190        200        210        220        230        240 
LGGKANGYPR EGGFDISVAS EVMAILCLAS DLKDLRSRLE RIIIGEDNDH NPVAAAKIKA 

       250        260        270        280        290        300 
AGAMTALLKD ALQPNLVQTL EGNPALIHGG PFANIAHGCN SLIATKAALH LGDIAITEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRQANL EPDAVVLVAT IRALKMHGGV ALADLKNENI AALETGFANL 

       370        380        390        400        410        420 
ARHAENLAKF GVKTVVAINR FHSDTEAELD KLQDLCASIG LDSAVCTHFT DGGAGAEDLA 

       430        440        450        460        470        480 
RKLSAILDAP KEDSFRLLYP DEMPLWKKIE TIAKEIYRAG EVVPQGTVLK KLKSFEEQGF 

       490        500        510        520        530        540 
GDLPVCIAKT QSSFSADPKA KNAPTGHIFP IREVRLNAGA GFIVAISGNI MTMPGLPRHP 

       550 
AAENIDINED NEIIGLA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008692 Genomic DNA. Translation: AAV89078.2.
RefSeqYP_162189.2. NC_006526.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264203.ZMO0454.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV89078; AAV89078; ZMO0454.
GeneID3189047.
KEGGzmo:ZMO0454.
PATRIC32566232. VBIZymMob102260_0427.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAHDSKITK.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ZYMMO
AccessionPrimary (citable) accession number: Q5NQC7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 23, 2010
Last modified: May 14, 2014
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways