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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:ZMO0454
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000199412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264203.ZMO0454.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NQC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDIEIARA ATLKPITEIA GRLNIPDESV LSYGHTIAKL DGEYLNSLSS
60 70 80 90 100
KPRGKLVLVS AITPTPAGEG KTTTTVGLGD AFNRIGKKAV ICLREPSLGP
110 120 130 140 150
CFGVKGGAAG GGYAQVVPME RINLHFTGDF HAITSAHDLL AAMIDNHVHW
160 170 180 190 200
GNEPVMDRNS ITFRRVIDMN DRMLRNMVIG LGGKANGYPR EGGFDISVAS
210 220 230 240 250
EVMAILCLAS DLKDLRSRLE RIIIGEDNDH NPVAAAKIKA AGAMTALLKD
260 270 280 290 300
ALQPNLVQTL EGNPALIHGG PFANIAHGCN SLIATKAALH LGDIAITEAG
310 320 330 340 350
FGADLGAEKF FDIKCRQANL EPDAVVLVAT IRALKMHGGV ALADLKNENI
360 370 380 390 400
AALETGFANL ARHAENLAKF GVKTVVAINR FHSDTEAELD KLQDLCASIG
410 420 430 440 450
LDSAVCTHFT DGGAGAEDLA RKLSAILDAP KEDSFRLLYP DEMPLWKKIE
460 470 480 490 500
TIAKEIYRAG EVVPQGTVLK KLKSFEEQGF GDLPVCIAKT QSSFSADPKA
510 520 530 540 550
KNAPTGHIFP IREVRLNAGA GFIVAISGNI MTMPGLPRHP AAENIDINED

NEIIGLA
Length:557
Mass (Da):59,286
Last modified:March 23, 2010 - v3
Checksum:iBB34CF581137F09D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV89078.2.
RefSeqiWP_011240364.1. NC_006526.2.
YP_162189.2. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89078; AAV89078; ZMO0454.
KEGGizmo:ZMO0454.
PATRICi32566232. VBIZymMob102260_0427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV89078.2.
RefSeqiWP_011240364.1. NC_006526.2.
YP_162189.2. NC_006526.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264203.ZMO0454.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV89078; AAV89078; ZMO0454.
KEGGizmo:ZMO0454.
PATRICi32566232. VBIZymMob102260_0427.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiFTHS_ZYMMO
AccessioniPrimary (citable) accession number: Q5NQC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 23, 2010
Last modified: April 29, 2015
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.