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Q5NQC7

- FTHS_ZYMMO

UniProt

Q5NQC7 - FTHS_ZYMMO

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, ZMO0454
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:ZMO0454
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264203.ZMO0454.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiHDSKITK.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NQC7-1 [UniParc]FASTAAdd to Basket

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MLSDIEIARA ATLKPITEIA GRLNIPDESV LSYGHTIAKL DGEYLNSLSS    50
KPRGKLVLVS AITPTPAGEG KTTTTVGLGD AFNRIGKKAV ICLREPSLGP 100
CFGVKGGAAG GGYAQVVPME RINLHFTGDF HAITSAHDLL AAMIDNHVHW 150
GNEPVMDRNS ITFRRVIDMN DRMLRNMVIG LGGKANGYPR EGGFDISVAS 200
EVMAILCLAS DLKDLRSRLE RIIIGEDNDH NPVAAAKIKA AGAMTALLKD 250
ALQPNLVQTL EGNPALIHGG PFANIAHGCN SLIATKAALH LGDIAITEAG 300
FGADLGAEKF FDIKCRQANL EPDAVVLVAT IRALKMHGGV ALADLKNENI 350
AALETGFANL ARHAENLAKF GVKTVVAINR FHSDTEAELD KLQDLCASIG 400
LDSAVCTHFT DGGAGAEDLA RKLSAILDAP KEDSFRLLYP DEMPLWKKIE 450
TIAKEIYRAG EVVPQGTVLK KLKSFEEQGF GDLPVCIAKT QSSFSADPKA 500
KNAPTGHIFP IREVRLNAGA GFIVAISGNI MTMPGLPRHP AAENIDINED 550
NEIIGLA 557
Length:557
Mass (Da):59,286
Last modified:March 23, 2010 - v3
Checksum:iBB34CF581137F09D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89078.2.
RefSeqiWP_011240364.1. NC_006526.2.
YP_162189.2. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89078; AAV89078; ZMO0454.
GeneIDi3189047.
KEGGizmo:ZMO0454.
PATRICi32566232. VBIZymMob102260_0427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89078.2 .
RefSeqi WP_011240364.1. NC_006526.2.
YP_162189.2. NC_006526.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO0454.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV89078 ; AAV89078 ; ZMO0454 .
GeneIDi 3189047.
KEGGi zmo:ZMO0454.
PATRICi 32566232. VBIZymMob102260_0427.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi HDSKITK.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.
  2. Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiFTHS_ZYMMO
AccessioniPrimary (citable) accession number: Q5NQC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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