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Protein

Adenine deaminase

Gene

ZMO0971

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Zinc; catalyticUniRule annotation1
Metal bindingi19Zinc; catalyticUniRule annotation1
Metal bindingi197Zinc; catalyticUniRule annotation1
Active sitei200Proton donorUniRule annotation1
Sitei221Important for catalytic activityUniRule annotation1
Metal bindingi278Zinc; catalyticUniRule annotation1
Binding sitei279SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciZMOB264203:G1FZK-876-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:ZMO0971
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000819341 – 337Adenine deaminaseAdd BLAST337

Structurei

3D structure databases

ProteinModelPortaliQ5NNW5
SMRiQ5NNW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218813
KOiK21053
OMAiRGWFRFQ

Family and domain databases

CDDicd01320 ADA, 1 hit
HAMAPiMF_01962 Adenine_deaminase, 1 hit
InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR028892 ADE
IPR006330 Ado/ade_deaminase
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01430 aden_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NNW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLIKFIAA LPKAELHLHI EGSLEPELMF ELAKRNKVTL PFPDVESVKA
60 70 80 90 100
AYNFNNLQEF LDIYYQGTNV LKTEEDFCDL AMAYFYRAHR DNVLHSEIFF
110 120 130 140 150
DPQSHTERGI PFNVVMNGLL AAITKAEAEL GMSVQLIMCF LRHLDEESAF
160 170 180 190 200
ATLRMAEPFL DKIAGVGLDS SEVGNPPSKF RHVFAEARQK GLKLVAHAGE
210 220 230 240 250
EGDASYIKEA LDILNIDRID HGNRITEDRL LMTRAARSAI ALTICPLSNQ
260 270 280 290 300
KLQVVPDLRN HPLPYLLRQG LRVTINSDDP AYFGGYVNDN YKALAEYCGL
310 320 330
KAADFVEIAR NSFLGSFLPD QTVAAYLDVL DKYVDSF
Length:337
Mass (Da):37,881
Last modified:February 1, 2005 - v1
Checksum:i05D23589D95CD2AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA Translation: AAV89595.1
RefSeqiWP_011240824.1, NC_006526.2

Genome annotation databases

EnsemblBacteriaiAAV89595; AAV89595; ZMO0971
KEGGizmo:ZMO0971

Similar proteinsi

Entry informationi

Entry nameiADE_ZYMMO
AccessioniPrimary (citable) accession number: Q5NNW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health