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Protein

Adenine deaminase

Gene

ZMO0971

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Zinc; catalyticUniRule annotation
Metal bindingi19 – 191Zinc; catalyticUniRule annotation
Metal bindingi197 – 1971Zinc; catalyticUniRule annotation
Active sitei200 – 2001Proton donorUniRule annotation
Sitei221 – 2211Important for catalytic activityUniRule annotation
Metal bindingi278 – 2781Zinc; catalyticUniRule annotation
Binding sitei279 – 2791SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:ZMO0971
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Adenine deaminasePRO_1000081934Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5NNW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.
OrthoDBiEOG6BPDDD.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NNW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLIKFIAA LPKAELHLHI EGSLEPELMF ELAKRNKVTL PFPDVESVKA
60 70 80 90 100
AYNFNNLQEF LDIYYQGTNV LKTEEDFCDL AMAYFYRAHR DNVLHSEIFF
110 120 130 140 150
DPQSHTERGI PFNVVMNGLL AAITKAEAEL GMSVQLIMCF LRHLDEESAF
160 170 180 190 200
ATLRMAEPFL DKIAGVGLDS SEVGNPPSKF RHVFAEARQK GLKLVAHAGE
210 220 230 240 250
EGDASYIKEA LDILNIDRID HGNRITEDRL LMTRAARSAI ALTICPLSNQ
260 270 280 290 300
KLQVVPDLRN HPLPYLLRQG LRVTINSDDP AYFGGYVNDN YKALAEYCGL
310 320 330
KAADFVEIAR NSFLGSFLPD QTVAAYLDVL DKYVDSF
Length:337
Mass (Da):37,881
Last modified:February 1, 2005 - v1
Checksum:i05D23589D95CD2AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV89595.1.
RefSeqiWP_011240824.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89595; AAV89595; ZMO0971.
KEGGizmo:ZMO0971.
PATRICi32567232. VBIZymMob102260_0915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV89595.1.
RefSeqiWP_011240824.1. NC_006526.2.

3D structure databases

ProteinModelPortaliQ5NNW5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV89595; AAV89595; ZMO0971.
KEGGizmo:ZMO0971.
PATRICi32567232. VBIZymMob102260_0915.

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.
OrthoDBiEOG6BPDDD.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiADE_ZYMMO
AccessioniPrimary (citable) accession number: Q5NNW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 1, 2005
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.