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Protein

Adenine deaminase

Gene

ZMO0971

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Zinc; catalyticUniRule annotation1
Metal bindingi19Zinc; catalyticUniRule annotation1
Metal bindingi197Zinc; catalyticUniRule annotation1
Active sitei200Proton donorUniRule annotation1
Sitei221Important for catalytic activityUniRule annotation1
Metal bindingi278Zinc; catalyticUniRule annotation1
Binding sitei279SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZMOB264203:GC4T-857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:ZMO0971
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000819341 – 337Adenine deaminaseAdd BLAST337

Structurei

3D structure databases

ProteinModelPortaliQ5NNW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.

Family and domain databases

CDDicd01320. ADA. 1 hit.
HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NNW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLIKFIAA LPKAELHLHI EGSLEPELMF ELAKRNKVTL PFPDVESVKA
60 70 80 90 100
AYNFNNLQEF LDIYYQGTNV LKTEEDFCDL AMAYFYRAHR DNVLHSEIFF
110 120 130 140 150
DPQSHTERGI PFNVVMNGLL AAITKAEAEL GMSVQLIMCF LRHLDEESAF
160 170 180 190 200
ATLRMAEPFL DKIAGVGLDS SEVGNPPSKF RHVFAEARQK GLKLVAHAGE
210 220 230 240 250
EGDASYIKEA LDILNIDRID HGNRITEDRL LMTRAARSAI ALTICPLSNQ
260 270 280 290 300
KLQVVPDLRN HPLPYLLRQG LRVTINSDDP AYFGGYVNDN YKALAEYCGL
310 320 330
KAADFVEIAR NSFLGSFLPD QTVAAYLDVL DKYVDSF
Length:337
Mass (Da):37,881
Last modified:February 1, 2005 - v1
Checksum:i05D23589D95CD2AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV89595.1.
RefSeqiWP_011240824.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89595; AAV89595; ZMO0971.
KEGGizmo:ZMO0971.
PATRICi32567232. VBIZymMob102260_0915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV89595.1.
RefSeqiWP_011240824.1. NC_006526.2.

3D structure databases

ProteinModelPortaliQ5NNW5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV89595; AAV89595; ZMO0971.
KEGGizmo:ZMO0971.
PATRICi32567232. VBIZymMob102260_0915.

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.

Enzyme and pathway databases

BioCyciZMOB264203:GC4T-857-MONOMER.

Family and domain databases

CDDicd01320. ADA. 1 hit.
HAMAPiMF_01962. Adenine_deaminase. 1 hit.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADE_ZYMMO
AccessioniPrimary (citable) accession number: Q5NNW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.