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Protein

1-deoxy-D-xylulose-5-phosphate synthase 1

Gene

dxs1

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi: 1-deoxy-D-xylulose 5-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 1-deoxy-D-xylulose-5-phosphate synthase 2 (dxs2), 1-deoxy-D-xylulose-5-phosphate synthase 1 (dxs1)
This subpathway is part of the pathway 1-deoxy-D-xylulose 5-phosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate, the pathway 1-deoxy-D-xylulose 5-phosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79Thiamine pyrophosphateUniRule annotation1
Metal bindingi151MagnesiumUniRule annotation1
Metal bindingi180MagnesiumUniRule annotation1
Binding sitei180Thiamine pyrophosphateUniRule annotation1
Binding sitei289Thiamine pyrophosphateUniRule annotation1
Binding sitei371Thiamine pyrophosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis, Thiamine biosynthesis
LigandMagnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciZMOB264203:G1FZK-1120-MONOMER
UniPathwayiUPA00064; UER00091

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 1UniRule annotation (EC:2.2.1.7UniRule annotation)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 1UniRule annotation
Short name:
DXP synthase 1UniRule annotation
Short name:
DXPS 1UniRule annotation
Gene namesi
Name:dxs1UniRule annotation
Ordered Locus Names:ZMO1234
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002565101 – 6491-deoxy-D-xylulose-5-phosphate synthase 1Add BLAST649

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5NN52
SMRiQ5NN52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 122Thiamine pyrophosphate bindingUniRule annotation3
Regioni152 – 153Thiamine pyrophosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the transketolase family. DXPS subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000012988
KOiK01662
OMAiAINHAGH

Family and domain databases

CDDicd02007 TPP_DXS, 1 hit
Gene3Di3.40.50.920, 1 hit
HAMAPiMF_00315 DXP_synth, 1 hit
InterProiView protein in InterPro
IPR005477 Dxylulose-5-P_synthase
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
IPR005474 Transketolase_N
PANTHERiPTHR43322 PTHR43322, 1 hit
PfamiView protein in Pfam
PF13292 DXP_synthase_N, 1 hit
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 3 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00204 dxs, 1 hit
PROSITEiView protein in PROSITE
PS00801 TRANSKETOLASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NN52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPNDKTPLL DKIKTPAELR QLDRNSLRQL ADELRKETIS AVGVTGGHLG
60 70 80 90 100
SGLGVIELTV ALHYVFNTPK DALVWDVGHQ TYPHKILTGR RDRIRTLRQR
110 120 130 140 150
DGLSGFTQRA ESEYDAFGAA HSSTSISAAL GFAMASKLSD SDDKAVAIIG
160 170 180 190 200
DGSMTAGMAY EAMNNAKAAG KRLIVILNDN EMSISPPVGA LSSYLSRLIS
210 220 230 240 250
SRPFMNLRDI MRGVVNRMPK GLATAARKAD EYARGMATGG TFFEELGFYY
260 270 280 290 300
VGPVDGHNLD QLIPVLENVR DAKDGPILVH VVTRKGQGYA PAEAAKDKYH
310 320 330 340 350
AVQRLDVVSG KQAKAPPGPP SYTSVFSEQL IKEAKQDDKI VTITAAMPTG
360 370 380 390 400
TGLDRFQQYF PERMFDVGIA EQHAVTFAAG LAAAGYKPFC CLYSTFLQRG
410 420 430 440 450
YDQLVHDVAI QNLPVRFAVD RAGLVGADGA THAGSFDLAF MVNLPNMVVM
460 470 480 490 500
APSDERELAN MVHSMAHYDQ GPISVRYPRG NGVGVSLEGE KEILPIGKGR
510 520 530 540 550
LIRRGKKVAI LSLGTRLEES LKAADRLDAQ GLSTSVADMR FAKPLDEALT
560 570 580 590 600
RQLLKSHQVI ITIEEGALGG FATQVLTMAS DEGLMDDGLK IRTLRLPDRF
610 620 630 640
QPQDKQERQY AEAGLDADGI VAAVISALHR NSKPVEVVEM ANMGSIARA
Length:649
Mass (Da):70,307
Last modified:February 1, 2005 - v1
Checksum:i772C535FBA83BE7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA Translation: AAV89858.1
RefSeqiWP_011241050.1, NC_006526.2

Genome annotation databases

EnsemblBacteriaiAAV89858; AAV89858; ZMO1234
KEGGizmo:ZMO1234

Similar proteinsi

Entry informationi

Entry nameiDXS1_ZYMMO
AccessioniPrimary (citable) accession number: Q5NN52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health