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Q5NN52

- DXS1_ZYMMO

UniProt

Q5NN52 - DXS1_ZYMMO

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Protein

1-deoxy-D-xylulose-5-phosphate synthase 1

Gene

dxs1

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation
Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Thiamine pyrophosphateUniRule annotation
Metal bindingi151 – 1511MagnesiumUniRule annotation
Metal bindingi180 – 1801MagnesiumUniRule annotation
Binding sitei180 – 1801Thiamine pyrophosphateUniRule annotation
Binding sitei289 – 2891Thiamine pyrophosphateUniRule annotation
Binding sitei371 – 3711Thiamine pyrophosphateUniRule annotation

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
  3. thiamine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Thiamine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

UniPathwayiUPA00064; UER00091.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 1UniRule annotation (EC:2.2.1.7UniRule annotation)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 1UniRule annotation
Short name:
DXP synthase 1UniRule annotation
Short name:
DXPS 1UniRule annotation
Gene namesi
Name:dxs1UniRule annotation
Ordered Locus Names:ZMO1234
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6496491-deoxy-D-xylulose-5-phosphate synthase 1PRO_0000256510Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi264203.ZMO1234.

Structurei

3D structure databases

ProteinModelPortaliQ5NN52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1223Thiamine pyrophosphate bindingUniRule annotation
Regioni152 – 1532Thiamine pyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the transketolase family. DXPS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1154.
HOGENOMiHOG000012988.
KOiK01662.
OMAiMSTIRQK.
OrthoDBiEOG6BKJ6P.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPiMF_00315. DXP_synth.
InterProiIPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00204. dxs. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NN52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPNDKTPLL DKIKTPAELR QLDRNSLRQL ADELRKETIS AVGVTGGHLG
60 70 80 90 100
SGLGVIELTV ALHYVFNTPK DALVWDVGHQ TYPHKILTGR RDRIRTLRQR
110 120 130 140 150
DGLSGFTQRA ESEYDAFGAA HSSTSISAAL GFAMASKLSD SDDKAVAIIG
160 170 180 190 200
DGSMTAGMAY EAMNNAKAAG KRLIVILNDN EMSISPPVGA LSSYLSRLIS
210 220 230 240 250
SRPFMNLRDI MRGVVNRMPK GLATAARKAD EYARGMATGG TFFEELGFYY
260 270 280 290 300
VGPVDGHNLD QLIPVLENVR DAKDGPILVH VVTRKGQGYA PAEAAKDKYH
310 320 330 340 350
AVQRLDVVSG KQAKAPPGPP SYTSVFSEQL IKEAKQDDKI VTITAAMPTG
360 370 380 390 400
TGLDRFQQYF PERMFDVGIA EQHAVTFAAG LAAAGYKPFC CLYSTFLQRG
410 420 430 440 450
YDQLVHDVAI QNLPVRFAVD RAGLVGADGA THAGSFDLAF MVNLPNMVVM
460 470 480 490 500
APSDERELAN MVHSMAHYDQ GPISVRYPRG NGVGVSLEGE KEILPIGKGR
510 520 530 540 550
LIRRGKKVAI LSLGTRLEES LKAADRLDAQ GLSTSVADMR FAKPLDEALT
560 570 580 590 600
RQLLKSHQVI ITIEEGALGG FATQVLTMAS DEGLMDDGLK IRTLRLPDRF
610 620 630 640
QPQDKQERQY AEAGLDADGI VAAVISALHR NSKPVEVVEM ANMGSIARA
Length:649
Mass (Da):70,307
Last modified:February 1, 2005 - v1
Checksum:i772C535FBA83BE7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89858.1.
RefSeqiYP_162969.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89858; AAV89858; ZMO1234.
GeneIDi3189041.
KEGGizmo:ZMO1234.
PATRICi32567764. VBIZymMob102260_1170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89858.1 .
RefSeqi YP_162969.1. NC_006526.2.

3D structure databases

ProteinModelPortali Q5NN52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV89858 ; AAV89858 ; ZMO1234 .
GeneIDi 3189041.
KEGGi zmo:ZMO1234.
PATRICi 32567764. VBIZymMob102260_1170.

Phylogenomic databases

eggNOGi COG1154.
HOGENOMi HOG000012988.
KOi K01662.
OMAi MSTIRQK.
OrthoDBi EOG6BKJ6P.

Enzyme and pathway databases

UniPathwayi UPA00064 ; UER00091 .

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPi MF_00315. DXP_synth.
InterProi IPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00204. dxs. 1 hit.
PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiDXS1_ZYMMO
AccessioniPrimary (citable) accession number: Q5NN52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 1, 2005
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3