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Q5NN52

- DXS1_ZYMMO

UniProt

Q5NN52 - DXS1_ZYMMO

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Protein
1-deoxy-D-xylulose-5-phosphate synthase 1
Gene
dxs1, ZMO1234
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.UniRule annotation

Catalytic activityi

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation
Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Thiamine pyrophosphate By similarity
Metal bindingi151 – 1511Magnesium By similarity
Metal bindingi180 – 1801Magnesium By similarity
Binding sitei180 – 1801Thiamine pyrophosphate By similarity
Binding sitei289 – 2891Thiamine pyrophosphate By similarity
Binding sitei371 – 3711Thiamine pyrophosphate By similarity

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
  3. thiamine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Thiamine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

UniPathwayiUPA00064; UER00091.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 1 (EC:2.2.1.7)
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 1
Short name:
DXP synthase 1
Short name:
DXPS 1
Gene namesi
Name:dxs1
Ordered Locus Names:ZMO1234
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6496491-deoxy-D-xylulose-5-phosphate synthase 1UniRule annotation
PRO_0000256510Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264203.ZMO1234.

Structurei

3D structure databases

ProteinModelPortaliQ5NN52.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1223Thiamine pyrophosphate binding By similarity
Regioni152 – 1532Thiamine pyrophosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1154.
HOGENOMiHOG000012988.
KOiK01662.
OMAiMSTIRQK.
OrthoDBiEOG6BKJ6P.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPiMF_00315. DXP_synth.
InterProiIPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00204. dxs. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NN52-1 [UniParc]FASTAAdd to Basket

« Hide

MFPNDKTPLL DKIKTPAELR QLDRNSLRQL ADELRKETIS AVGVTGGHLG    50
SGLGVIELTV ALHYVFNTPK DALVWDVGHQ TYPHKILTGR RDRIRTLRQR 100
DGLSGFTQRA ESEYDAFGAA HSSTSISAAL GFAMASKLSD SDDKAVAIIG 150
DGSMTAGMAY EAMNNAKAAG KRLIVILNDN EMSISPPVGA LSSYLSRLIS 200
SRPFMNLRDI MRGVVNRMPK GLATAARKAD EYARGMATGG TFFEELGFYY 250
VGPVDGHNLD QLIPVLENVR DAKDGPILVH VVTRKGQGYA PAEAAKDKYH 300
AVQRLDVVSG KQAKAPPGPP SYTSVFSEQL IKEAKQDDKI VTITAAMPTG 350
TGLDRFQQYF PERMFDVGIA EQHAVTFAAG LAAAGYKPFC CLYSTFLQRG 400
YDQLVHDVAI QNLPVRFAVD RAGLVGADGA THAGSFDLAF MVNLPNMVVM 450
APSDERELAN MVHSMAHYDQ GPISVRYPRG NGVGVSLEGE KEILPIGKGR 500
LIRRGKKVAI LSLGTRLEES LKAADRLDAQ GLSTSVADMR FAKPLDEALT 550
RQLLKSHQVI ITIEEGALGG FATQVLTMAS DEGLMDDGLK IRTLRLPDRF 600
QPQDKQERQY AEAGLDADGI VAAVISALHR NSKPVEVVEM ANMGSIARA 649
Length:649
Mass (Da):70,307
Last modified:February 1, 2005 - v1
Checksum:i772C535FBA83BE7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89858.1.
RefSeqiYP_162969.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89858; AAV89858; ZMO1234.
GeneIDi3189041.
KEGGizmo:ZMO1234.
PATRICi32567764. VBIZymMob102260_1170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89858.1 .
RefSeqi YP_162969.1. NC_006526.2.

3D structure databases

ProteinModelPortali Q5NN52.
ModBasei Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV89858 ; AAV89858 ; ZMO1234 .
GeneIDi 3189041.
KEGGi zmo:ZMO1234.
PATRICi 32567764. VBIZymMob102260_1170.

Phylogenomic databases

eggNOGi COG1154.
HOGENOMi HOG000012988.
KOi K01662.
OMAi MSTIRQK.
OrthoDBi EOG6BKJ6P.

Enzyme and pathway databases

UniPathwayi UPA00064 ; UER00091 .

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 3 hits.
HAMAPi MF_00315. DXP_synth.
InterProi IPR005477. Dxylulose-5-P_synthase.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 3 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00204. dxs. 1 hit.
PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiDXS1_ZYMMO
AccessioniPrimary (citable) accession number: Q5NN52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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