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Q5NN52

- DXS1_ZYMMO

UniProt

Q5NN52 - DXS1_ZYMMO

Protein

1-deoxy-D-xylulose-5-phosphate synthase 1

Gene

dxs1

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

    Catalytic activityi

    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791Thiamine pyrophosphateUniRule annotation
    Metal bindingi151 – 1511MagnesiumUniRule annotation
    Metal bindingi180 – 1801MagnesiumUniRule annotation
    Binding sitei180 – 1801Thiamine pyrophosphateUniRule annotation
    Binding sitei289 – 2891Thiamine pyrophosphateUniRule annotation
    Binding sitei371 – 3711Thiamine pyrophosphateUniRule annotation

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
    3. thiamine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Thiamine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    UniPathwayiUPA00064; UER00091.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase 1UniRule annotation (EC:2.2.1.7UniRule annotation)
    Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase 1UniRule annotation
    Short name:
    DXP synthase 1UniRule annotation
    Short name:
    DXPS 1UniRule annotation
    Gene namesi
    Name:dxs1UniRule annotation
    Ordered Locus Names:ZMO1234
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6496491-deoxy-D-xylulose-5-phosphate synthase 1PRO_0000256510Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi264203.ZMO1234.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NN52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni120 – 1223Thiamine pyrophosphate bindingUniRule annotation
    Regioni152 – 1532Thiamine pyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the transketolase family. DXPS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1154.
    HOGENOMiHOG000012988.
    KOiK01662.
    OMAiMSTIRQK.
    OrthoDBiEOG6BKJ6P.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPiMF_00315. DXP_synth.
    InterProiIPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00204. dxs. 1 hit.
    PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NN52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPNDKTPLL DKIKTPAELR QLDRNSLRQL ADELRKETIS AVGVTGGHLG    50
    SGLGVIELTV ALHYVFNTPK DALVWDVGHQ TYPHKILTGR RDRIRTLRQR 100
    DGLSGFTQRA ESEYDAFGAA HSSTSISAAL GFAMASKLSD SDDKAVAIIG 150
    DGSMTAGMAY EAMNNAKAAG KRLIVILNDN EMSISPPVGA LSSYLSRLIS 200
    SRPFMNLRDI MRGVVNRMPK GLATAARKAD EYARGMATGG TFFEELGFYY 250
    VGPVDGHNLD QLIPVLENVR DAKDGPILVH VVTRKGQGYA PAEAAKDKYH 300
    AVQRLDVVSG KQAKAPPGPP SYTSVFSEQL IKEAKQDDKI VTITAAMPTG 350
    TGLDRFQQYF PERMFDVGIA EQHAVTFAAG LAAAGYKPFC CLYSTFLQRG 400
    YDQLVHDVAI QNLPVRFAVD RAGLVGADGA THAGSFDLAF MVNLPNMVVM 450
    APSDERELAN MVHSMAHYDQ GPISVRYPRG NGVGVSLEGE KEILPIGKGR 500
    LIRRGKKVAI LSLGTRLEES LKAADRLDAQ GLSTSVADMR FAKPLDEALT 550
    RQLLKSHQVI ITIEEGALGG FATQVLTMAS DEGLMDDGLK IRTLRLPDRF 600
    QPQDKQERQY AEAGLDADGI VAAVISALHR NSKPVEVVEM ANMGSIARA 649
    Length:649
    Mass (Da):70,307
    Last modified:February 1, 2005 - v1
    Checksum:i772C535FBA83BE7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV89858.1.
    RefSeqiYP_162969.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV89858; AAV89858; ZMO1234.
    GeneIDi3189041.
    KEGGizmo:ZMO1234.
    PATRICi32567764. VBIZymMob102260_1170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV89858.1 .
    RefSeqi YP_162969.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q5NN52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO1234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV89858 ; AAV89858 ; ZMO1234 .
    GeneIDi 3189041.
    KEGGi zmo:ZMO1234.
    PATRICi 32567764. VBIZymMob102260_1170.

    Phylogenomic databases

    eggNOGi COG1154.
    HOGENOMi HOG000012988.
    KOi K01662.
    OMAi MSTIRQK.
    OrthoDBi EOG6BKJ6P.

    Enzyme and pathway databases

    UniPathwayi UPA00064 ; UER00091 .

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPi MF_00315. DXP_synth.
    InterProi IPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00204. dxs. 1 hit.
    PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiDXS1_ZYMMO
    AccessioniPrimary (citable) accession number: Q5NN52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3