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Q5NMX3

- PDXA_ZYMMO

UniProt

Q5NMX3 - PDXA_ZYMMO

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene
pdxA, ZMO1313
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321Substrate By similarity
Metal bindingi163 – 1631Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi208 – 2081Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi263 – 2631Divalent metal cation; shared with dimeric partner By similarity
Binding sitei271 – 2711Substrate By similarity
Binding sitei280 – 2801Substrate By similarity
Binding sitei289 – 2891Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:ZMO1313
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3353354-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotationPRO_1000051526Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264203.ZMO1313.

Structurei

3D structure databases

ProteinModelPortaliQ5NMX3.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiDTLFQDK.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NMX3-1 [UniParc]FASTAAdd to Basket

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MKPLAVTLGD PSGIGPEIVA KAWSRRKSDQ IMPFFAIGSA ASIQAVSSIP    50
VVAITDPNEA ISIFDQALPV WDIPSKETIT PGKPNKAGAE VAFAALEKGV 100
ALVKQGQASA LVTAPVSKAE LYQVGFTFPG QTEFVANRCG IAADDAVMML 150
AGPDLRTVPL TIHIPYRDVL EQLTPKLIIS RARVTVEDLK RNFAIPSPRL 200
VVAGLNPHAG ENGTIGREEI DSIEPAIRQL QAENIDIKGP FAADTLFSPR 250
ARATYDVALC PTHDQALIPI KTINFDNGVN TTLGLPIIRT SPDHGTAFPL 300
AGKNKADEGA MVAALVMAAN SAHNRQAYAQ NSIDG 335
Length:335
Mass (Da):35,453
Last modified:February 1, 2005 - v1
Checksum:i399463F50DAB2773
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89937.1.
RefSeqiYP_163048.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89937; AAV89937; ZMO1313.
GeneIDi3188624.
KEGGizmo:ZMO1313.
PATRICi32567912. VBIZymMob102260_1244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008692 Genomic DNA. Translation: AAV89937.1 .
RefSeqi YP_163048.1. NC_006526.2.

3D structure databases

ProteinModelPortali Q5NMX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1313.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV89937 ; AAV89937 ; ZMO1313 .
GeneIDi 3188624.
KEGGi zmo:ZMO1313.
PATRICi 32567912. VBIZymMob102260_1244.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi DTLFQDK.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiPDXA_ZYMMO
AccessioniPrimary (citable) accession number: Q5NMX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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