Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5NMK1

- SYL_ZYMMO

UniProt

Q5NMK1 - SYL_ZYMMO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei624 – 6241ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ZMO1435
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Leucine--tRNA ligasePRO_0000152126Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264203.ZMO1435.

Structurei

3D structure databases

ProteinModelPortaliQ5NMK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionAdd
BLAST
Motifi621 – 6255"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NMK1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESGFSQRF NPHVVDGRWQ KKWEESGCFH AKDNSDRPHS YILEMFPYPS
60 70 80 90 100
GRIHMGHVRN YTMGDVLARY YRMKGHEVLH PMGWDAFGMP AENAAMERKI
110 120 130 140 150
HPREWTMSNI ATMREQLKRI GFAIDWSREL ATCEPSYYGQ EQALFLDLYK
160 170 180 190 200
AGLVYRKESA VNWDPIDNTV LANEQVIDGR GWRSGALVER KKLNQWFLKI
210 220 230 240 250
TEFADDLLDG LKDLDQWPEK VRSMQENWIG RSQGMQFHFN FEVAPEGFDK
260 270 280 290 300
IEVFTTRPDT LFGASFVAIA CDHPIAKALA EKNAALPEFI ADCQKMGTAA
310 320 330 340 350
EDIETAEKKG FDTGLSLVHP LNPELKLPLF VANFVLMDYG TGAVFGCPAH
360 370 380 390 400
DQRDLDFALK YNLPVKRVVA PSEAESNEAI GDKADTRAGI MVNSSFLDGL
410 420 430 440 450
SSEEAKKTVI ARAEKEGWGK GTTVFRLRDW GVSRQRYWGT PIPIIHCDSC
460 470 480 490 500
GAVPVPKDQL PVTLPDDINF DKPGNPLERH PTWKNVTCPK CGKPARRETD
510 520 530 540 550
TLDTFVDSSW YFIRFASQPD DKPFDKATAE KWLPVGQYIG GVEHAILHLL
560 570 580 590 600
YARFWTRALQ SIGRLDIKEP FTGLFTQGMV THETYKDPEG HWLSPEQIHK
610 620 630 640 650
DEAGIFLTES GEKVTVGRVE KMSKSKKNVV EPAPILDQYG ADAVRWFMLS
660 670 680 690 700
DSPPERDLAW TEAGIEGCWR FMQRLWRVAA IASEEASAGI DKDLQHRLHC
710 720 730 740 750
SIKEVGEAIE GLSFNKAIAK IHDLVNAIEK AKASATRKEA ALTLFRLVAP
760 770 780 790 800
MVPHLSEEAW HLLEKEGFVA EASWPEFDPA LTVEDEITIA VQVNGKLRDT
810 820 830 840
LTVARDMPKD EAEKLALASE KVIKMLEGRS PKKVIVVPNR LVNIVA
Length:846
Mass (Da):95,428
Last modified:February 1, 2005 - v1
Checksum:i3A727DDA60F0CB44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV90059.1.
RefSeqiYP_163170.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV90059; AAV90059; ZMO1435.
GeneIDi3188964.
KEGGizmo:ZMO1435.
PATRICi32568142. VBIZymMob102260_1356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA. Translation: AAV90059.1 .
RefSeqi YP_163170.1. NC_006526.2.

3D structure databases

ProteinModelPortali Q5NMK1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264203.ZMO1435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV90059 ; AAV90059 ; ZMO1435 .
GeneIDi 3188964.
KEGGi zmo:ZMO1435.
PATRICi 32568142. VBIZymMob102260_1356.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiSYL_ZYMMO
AccessioniPrimary (citable) accession number: Q5NMK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3