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Q5NMK1

- SYL_ZYMMO

UniProt

Q5NMK1 - SYL_ZYMMO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei624 – 6241ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:ZMO1435
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 846846Leucine--tRNA ligasePRO_0000152126Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264203.ZMO1435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NMK1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi47 – 5711"HIGH" regionAdd
    BLAST
    Motifi621 – 6255"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NMK1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESGFSQRF NPHVVDGRWQ KKWEESGCFH AKDNSDRPHS YILEMFPYPS    50
    GRIHMGHVRN YTMGDVLARY YRMKGHEVLH PMGWDAFGMP AENAAMERKI 100
    HPREWTMSNI ATMREQLKRI GFAIDWSREL ATCEPSYYGQ EQALFLDLYK 150
    AGLVYRKESA VNWDPIDNTV LANEQVIDGR GWRSGALVER KKLNQWFLKI 200
    TEFADDLLDG LKDLDQWPEK VRSMQENWIG RSQGMQFHFN FEVAPEGFDK 250
    IEVFTTRPDT LFGASFVAIA CDHPIAKALA EKNAALPEFI ADCQKMGTAA 300
    EDIETAEKKG FDTGLSLVHP LNPELKLPLF VANFVLMDYG TGAVFGCPAH 350
    DQRDLDFALK YNLPVKRVVA PSEAESNEAI GDKADTRAGI MVNSSFLDGL 400
    SSEEAKKTVI ARAEKEGWGK GTTVFRLRDW GVSRQRYWGT PIPIIHCDSC 450
    GAVPVPKDQL PVTLPDDINF DKPGNPLERH PTWKNVTCPK CGKPARRETD 500
    TLDTFVDSSW YFIRFASQPD DKPFDKATAE KWLPVGQYIG GVEHAILHLL 550
    YARFWTRALQ SIGRLDIKEP FTGLFTQGMV THETYKDPEG HWLSPEQIHK 600
    DEAGIFLTES GEKVTVGRVE KMSKSKKNVV EPAPILDQYG ADAVRWFMLS 650
    DSPPERDLAW TEAGIEGCWR FMQRLWRVAA IASEEASAGI DKDLQHRLHC 700
    SIKEVGEAIE GLSFNKAIAK IHDLVNAIEK AKASATRKEA ALTLFRLVAP 750
    MVPHLSEEAW HLLEKEGFVA EASWPEFDPA LTVEDEITIA VQVNGKLRDT 800
    LTVARDMPKD EAEKLALASE KVIKMLEGRS PKKVIVVPNR LVNIVA 846
    Length:846
    Mass (Da):95,428
    Last modified:February 1, 2005 - v1
    Checksum:i3A727DDA60F0CB44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV90059.1.
    RefSeqiWP_011241216.1. NC_006526.2.
    YP_163170.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV90059; AAV90059; ZMO1435.
    GeneIDi3188964.
    KEGGizmo:ZMO1435.
    PATRICi32568142. VBIZymMob102260_1356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV90059.1 .
    RefSeqi WP_011241216.1. NC_006526.2.
    YP_163170.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q5NMK1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO1435.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV90059 ; AAV90059 ; ZMO1435 .
    GeneIDi 3188964.
    KEGGi zmo:ZMO1435.
    PATRICi 32568142. VBIZymMob102260_1356.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiSYL_ZYMMO
    AccessioniPrimary (citable) accession number: Q5NMK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3