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Q5NLX5

- PROA_ZYMMO

UniProt

Q5NLX5 - PROA_ZYMMO

Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

    Catalytic activityi

    L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00098; UER00360.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
    Short name:
    GPRUniRule annotation
    Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
    Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
    Short name:
    GSA dehydrogenaseUniRule annotation
    Gene namesi
    Name:proAUniRule annotation
    Ordered Locus Names:ZMO1661
    OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
    Taxonomic identifieri264203 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
    ProteomesiUP000001173: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Gamma-glutamyl phosphate reductasePRO_0000189820Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264203.ZMO1661.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NLX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0014.
    HOGENOMiHOG000246356.
    KOiK00147.
    OMAiALTSYKW.
    OrthoDBiEOG6FFSCX.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPiMF_00412. ProA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000151. GPR. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00407. proA. 1 hit.
    PROSITEiPS01223. PROA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NLX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGNKIDQAT PTEMMAGMAK KARLASQILA QAPTAQKAEA LVLTADAIRR    50
    HSADILAANA QDVATAENNQ SSSAMVDRLR LTEARLENMA SALEVIAHLE 100
    DPVGQIIDKR TRPNGLELTR IRVPIGVIGI IYESRPNVTI DAAALTLMSG 150
    NAAILRGGSE AIHSNKALYQ TMREGLAKAG LPEEAIQLVP TTDRALVGAM 200
    LTASGLIDLV IPRGGKSLVA RVQQDARVPV LAHLDGINHS YVHKEADPEK 250
    VEKVVVNAKM RRTGICGATE SLLIDRGYPV EKVKSLLQAL HNAGCEIRGT 300
    AEIQKIDPEA KAVSEEDWGT EYLDAVLSVR FVDDMDDALS HIARYSSGHT 350
    DAILTENREV AEKFLASVDS AIVMWNASTQ FADGGEFGLG AEIGIATGRI 400
    HARGPVALEG LTSYKWQVRG TGQIRPVA 428
    Length:428
    Mass (Da):45,809
    Last modified:February 1, 2005 - v1
    Checksum:i33643683D7674537
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV90285.1.
    RefSeqiYP_163396.1. NC_006526.2.

    Genome annotation databases

    EnsemblBacteriaiAAV90285; AAV90285; ZMO1661.
    GeneIDi3188730.
    KEGGizmo:ZMO1661.
    PATRICi32568586. VBIZymMob102260_1568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008692 Genomic DNA. Translation: AAV90285.1 .
    RefSeqi YP_163396.1. NC_006526.2.

    3D structure databases

    ProteinModelPortali Q5NLX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264203.ZMO1661.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV90285 ; AAV90285 ; ZMO1661 .
    GeneIDi 3188730.
    KEGGi zmo:ZMO1661.
    PATRICi 32568586. VBIZymMob102260_1568.

    Phylogenomic databases

    eggNOGi COG0014.
    HOGENOMi HOG000246356.
    KOi K00147.
    OMAi ALTSYKW.
    OrthoDBi EOG6FFSCX.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00360 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPi MF_00412. ProA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000151. GPR. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00407. proA. 1 hit.
    PROSITEi PS01223. PROA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31821 / ZM4 / CP4.

    Entry informationi

    Entry nameiPROA_ZYMMO
    AccessioniPrimary (citable) accession number: Q5NLX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3