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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciZMOB264203:G1FZK-1507-MONOMER
UniPathwayiUPA00098; UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:ZMO1661
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001898201 – 428Gamma-glutamyl phosphate reductaseAdd BLAST428

Proteomic databases

PRIDEiQ5NLX5

Structurei

3D structure databases

ProteinModelPortaliQ5NLX5
SMRiQ5NLX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246356
KOiK00147
OMAiHGSHHTD

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5NLX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGNKIDQAT PTEMMAGMAK KARLASQILA QAPTAQKAEA LVLTADAIRR
60 70 80 90 100
HSADILAANA QDVATAENNQ SSSAMVDRLR LTEARLENMA SALEVIAHLE
110 120 130 140 150
DPVGQIIDKR TRPNGLELTR IRVPIGVIGI IYESRPNVTI DAAALTLMSG
160 170 180 190 200
NAAILRGGSE AIHSNKALYQ TMREGLAKAG LPEEAIQLVP TTDRALVGAM
210 220 230 240 250
LTASGLIDLV IPRGGKSLVA RVQQDARVPV LAHLDGINHS YVHKEADPEK
260 270 280 290 300
VEKVVVNAKM RRTGICGATE SLLIDRGYPV EKVKSLLQAL HNAGCEIRGT
310 320 330 340 350
AEIQKIDPEA KAVSEEDWGT EYLDAVLSVR FVDDMDDALS HIARYSSGHT
360 370 380 390 400
DAILTENREV AEKFLASVDS AIVMWNASTQ FADGGEFGLG AEIGIATGRI
410 420
HARGPVALEG LTSYKWQVRG TGQIRPVA
Length:428
Mass (Da):45,809
Last modified:February 1, 2005 - v1
Checksum:i33643683D7674537
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008692 Genomic DNA Translation: AAV90285.1
RefSeqiWP_011241410.1, NC_006526.2

Genome annotation databases

EnsemblBacteriaiAAV90285; AAV90285; ZMO1661
KEGGizmo:ZMO1661

Similar proteinsi

Entry informationi

Entry nameiPROA_ZYMMO
AccessioniPrimary (citable) accession number: Q5NLX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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