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Protein

Intercellular adhesion molecule 2

Gene

ICAM2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 2
Short name:
ICAM-2
Alternative name(s):
CD_antigen: CD102
Gene namesi
Name:ICAM2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:9329 ICAM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 223ExtracellularSequence analysisAdd BLAST199
Transmembranei224 – 248HelicalSequence analysisAdd BLAST25
Topological domaini249 – 275CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001479225 – 275Intercellular adhesion molecule 2Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 91By similarity
Disulfide bondi52 ↔ 95By similarity
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 190By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5NKV2

Expressioni

Gene expression databases

BgeeiENSPTRG00000009534

Interactioni

Subunit structurei

Interacts with RDX, EZR and MSN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016198

Structurei

3D structure databases

ProteinModelPortaliQ5NKV2
SMRiQ5NKV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 98Ig-like C2-type 1Add BLAST58
Domaini127 – 197Ig-like C2-type 2Add BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 275Required for interaction with EZR, MSN and RDX and co-localization to microvilliBy similarityAdd BLAST25

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH57 Eukaryota
ENOG410Z9H1 LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000049136
HOVERGENiHBG052075
InParanoidiQ5NKV2
KOiK06523
OMAiNFSCLAV
OrthoDBiEOG091G022Y
TreeFamiTF333745

Family and domain databases

Gene3Di2.60.40.102 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR015653 ICAM2
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PANTHERiPTHR13771:SF3 PTHR13771:SF3, 1 hit
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NKV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFSYRTLT VALFALICCP GSDEKVFEVH VRPKKLAVEP KGSLKVNCST
60 70 80 90 100
TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE
110 120 130 140 150
SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF
160 170 180 190 200
RGNETLHYET FGKAAPAPQE ATVTFNSTAD RDDGHRNFSC LAVLDLMSRG
210 220 230 240 250
GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ
260 270
HLRQQRMGTY GVRAAWRRLP QAFRP
Length:275
Mass (Da):30,667
Last modified:February 1, 2005 - v1
Checksum:iCA3A5048712A59B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF340049 mRNA Translation: AAQ14906.1
AF340050 mRNA Translation: AAQ14907.1
RefSeqiNP_001009166.1, NM_001009166.1
XP_009431260.1, XM_009432985.2
XP_009431261.1, XM_009432986.1
UniGeneiPtr.6181

Genome annotation databases

EnsembliENSPTRT00000017489; ENSPTRP00000016198; ENSPTRG00000009534
GeneIDi494137
KEGGiptr:494137

Similar proteinsi

Entry informationi

Entry nameiICAM2_PANTR
AccessioniPrimary (citable) accession number: Q5NKV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome