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Protein

Intercellular adhesion molecule 2

Gene

ICAM2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 2
Short name:
ICAM-2
Alternative name(s):
CD_antigen: CD102
Gene namesi
Name:ICAM2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 223ExtracellularSequence analysisAdd BLAST199
Transmembranei224 – 248HelicalSequence analysisAdd BLAST25
Topological domaini249 – 275CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001479225 – 275Intercellular adhesion molecule 2Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi48 ↔ 91By similarity
Disulfide bondi52 ↔ 95By similarity
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi134 ↔ 190By similarity
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5NKV2.

Expressioni

Gene expression databases

BgeeiENSPTRG00000009534.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016198.

Structurei

3D structure databases

ProteinModelPortaliQ5NKV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 98Ig-like C2-type 1Add BLAST58
Domaini127 – 197Ig-like C2-type 2Add BLAST71

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH57. Eukaryota.
ENOG410Z9H1. LUCA.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000049136.
HOVERGENiHBG052075.
InParanoidiQ5NKV2.
KOiK06523.
OMAiNFSCLAV.
OrthoDBiEOG091G022Y.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003988. ICAM.
IPR015653. ICAM2.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR13771:SF3. PTHR13771:SF3. 1 hit.
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NKV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFSYRTLT VALFALICCP GSDEKVFEVH VRPKKLAVEP KGSLKVNCST
60 70 80 90 100
TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE
110 120 130 140 150
SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF
160 170 180 190 200
RGNETLHYET FGKAAPAPQE ATVTFNSTAD RDDGHRNFSC LAVLDLMSRG
210 220 230 240 250
GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ
260 270
HLRQQRMGTY GVRAAWRRLP QAFRP
Length:275
Mass (Da):30,667
Last modified:February 1, 2005 - v1
Checksum:iCA3A5048712A59B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF340049 mRNA. Translation: AAQ14906.1.
AF340050 mRNA. Translation: AAQ14907.1.
RefSeqiNP_001009166.1. NM_001009166.1.
XP_009431260.1. XM_009432985.2.
XP_009431261.1. XM_009432986.1.
UniGeneiPtr.6181.

Genome annotation databases

EnsembliENSPTRT00000017489; ENSPTRP00000016198; ENSPTRG00000009534.
GeneIDi494137.
KEGGiptr:494137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF340049 mRNA. Translation: AAQ14906.1.
AF340050 mRNA. Translation: AAQ14907.1.
RefSeqiNP_001009166.1. NM_001009166.1.
XP_009431260.1. XM_009432985.2.
XP_009431261.1. XM_009432986.1.
UniGeneiPtr.6181.

3D structure databases

ProteinModelPortaliQ5NKV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016198.

Proteomic databases

PaxDbiQ5NKV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000017489; ENSPTRP00000016198; ENSPTRG00000009534.
GeneIDi494137.
KEGGiptr:494137.

Organism-specific databases

CTDi3384.

Phylogenomic databases

eggNOGiENOG410IH57. Eukaryota.
ENOG410Z9H1. LUCA.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000049136.
HOVERGENiHBG052075.
InParanoidiQ5NKV2.
KOiK06523.
OMAiNFSCLAV.
OrthoDBiEOG091G022Y.
TreeFamiTF333745.

Gene expression databases

BgeeiENSPTRG00000009534.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003988. ICAM.
IPR015653. ICAM2.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR13771:SF3. PTHR13771:SF3. 1 hit.
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiICAM2_PANTR
AccessioniPrimary (citable) accession number: Q5NKV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 1, 2005
Last modified: October 5, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.