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Q5NIP6

- GATA_FRATT

UniProt

Q5NIP6 - GATA_FRATT

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Protein
Glutamyl-tRNA(Gln) amidotransferase subunit A
Gene
gatA, FTT_0020
Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Charge relay system By similarity
Active sitei149 – 1491Charge relay system By similarity
Active sitei173 – 1731Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-20-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit A (EC:6.3.5.7)
Short name:
Glu-ADT subunit A
Gene namesi
Name:gatA
Ordered Locus Names:FTT_0020
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation
PRO_0000241103Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ5NIP6. 15 interactions.
STRINGi177416.FTT_0020.

Structurei

3D structure databases

ProteinModelPortaliQ5NIP6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0154.
HOGENOMiHOG000116699.
KOiK02433.
OMAiGKPFAEE.
OrthoDBiEOG61P6R9.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
TIGRFAMsiTIGR00132. gatA. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NIP6-1 [UniParc]FASTAAdd to Basket

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MSYIKKLRAR LDSGEISAVE LTKEYLAKIK EQDKRINSVI TLCEAEALKE    50
AEDADAIISA GKQGLLTGIP ILHKDLFCTK GIRTTAASKM LDNFVAPYDS 100
TVTKNCKDQG MVTLGKLNMD EFAMGSTNEY SYYGAVSNPW DLERVPGGSS 150
GGSAAAVAAG FAPISTGSDT GGSVRQPASF CGLTAMKPSY GSTSRFGMVA 200
FASSFDQAGV LGHYAEDVAI MLDAIAGECE FDSTCVGVKQ NHFTQDLEKD 250
ISGKVIGVDE SLIKDLPAQI QEAVSKTLDN FKKLGAEIKS VKVPDLKEAL 300
STYYIITPAE AAANLARYDG IRYGYRNPEA RDLDELYRKS RTDGFGAEVK 350
RRIMIGNYVL ASSQYDSYYN KAQQLRKVMT DQINQIFTQV DAIFMPASPS 400
EAFKKGDKLD PVSAYLSDIY TIPANISGLP AIAFPIGFAN NLPVGGQLMA 450
KAFNDNILTQ MVVQYQKHYG IEEFILQQAR I 481
Length:481
Mass (Da):52,303
Last modified:February 1, 2005 - v1
Checksum:iCA141F67B99F5F72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG44653.1.
RefSeqiYP_169096.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG44653; CAG44653; FTT_0020.
GeneIDi3191915.
KEGGiftu:FTT_0020.
PATRICi17962991. VBIFraTul2086_0023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG44653.1 .
RefSeqi YP_169096.1. NC_006570.2.

3D structure databases

ProteinModelPortali Q5NIP6.
ModBasei Search...

Protein-protein interaction databases

IntActi Q5NIP6. 15 interactions.
STRINGi 177416.FTT_0020.

Protocols and materials databases

DNASUi 3191915.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG44653 ; CAG44653 ; FTT_0020 .
GeneIDi 3191915.
KEGGi ftu:FTT_0020.
PATRICi 17962991. VBIFraTul2086_0023.

Phylogenomic databases

eggNOGi COG0154.
HOGENOMi HOG000116699.
KOi K02433.
OMAi GKPFAEE.
OrthoDBi EOG61P6R9.

Enzyme and pathway databases

BioCyci FTUL177416:GNBP-20-MONOMER.

Family and domain databases

Gene3Di 3.90.1300.10. 1 hit.
HAMAPi MF_00120. GatA.
InterProi IPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view ]
PANTHERi PTHR11895. PTHR11895. 1 hit.
Pfami PF01425. Amidase. 1 hit.
[Graphical view ]
SUPFAMi SSF75304. SSF75304. 1 hit.
TIGRFAMsi TIGR00132. gatA. 1 hit.
PROSITEi PS00571. AMIDASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiGATA_FRATT
AccessioniPrimary (citable) accession number: Q5NIP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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