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Q5NIP6

- GATA_FRATT

UniProt

Q5NIP6 - GATA_FRATT

Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Charge relay systemUniRule annotation
    Active sitei149 – 1491Charge relay systemUniRule annotation
    Active sitei173 – 1731Acyl-ester intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFTUL177416:GNBP-20-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
    Short name:
    Glu-ADT subunit AUniRule annotation
    Gene namesi
    Name:gatAUniRule annotation
    Ordered Locus Names:FTT_0020
    OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
    Taxonomic identifieri177416 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001174: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Glutamyl-tRNA(Gln) amidotransferase subunit APRO_0000241103Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of A, B and C subunits.UniRule annotation

    Protein-protein interaction databases

    IntActiQ5NIP6. 15 interactions.
    STRINGi177416.FTT_0020.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NIP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the amidase family. GatA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0154.
    HOGENOMiHOG000116699.
    KOiK02433.
    OMAiGKPFAEE.
    OrthoDBiEOG61P6R9.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    HAMAPiMF_00120. GatA.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 1 hit.
    TIGRFAMsiTIGR00132. gatA. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NIP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYIKKLRAR LDSGEISAVE LTKEYLAKIK EQDKRINSVI TLCEAEALKE    50
    AEDADAIISA GKQGLLTGIP ILHKDLFCTK GIRTTAASKM LDNFVAPYDS 100
    TVTKNCKDQG MVTLGKLNMD EFAMGSTNEY SYYGAVSNPW DLERVPGGSS 150
    GGSAAAVAAG FAPISTGSDT GGSVRQPASF CGLTAMKPSY GSTSRFGMVA 200
    FASSFDQAGV LGHYAEDVAI MLDAIAGECE FDSTCVGVKQ NHFTQDLEKD 250
    ISGKVIGVDE SLIKDLPAQI QEAVSKTLDN FKKLGAEIKS VKVPDLKEAL 300
    STYYIITPAE AAANLARYDG IRYGYRNPEA RDLDELYRKS RTDGFGAEVK 350
    RRIMIGNYVL ASSQYDSYYN KAQQLRKVMT DQINQIFTQV DAIFMPASPS 400
    EAFKKGDKLD PVSAYLSDIY TIPANISGLP AIAFPIGFAN NLPVGGQLMA 450
    KAFNDNILTQ MVVQYQKHYG IEEFILQQAR I 481
    Length:481
    Mass (Da):52,303
    Last modified:February 1, 2005 - v1
    Checksum:iCA141F67B99F5F72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG44653.1.
    RefSeqiYP_169096.1. NC_006570.2.

    Genome annotation databases

    EnsemblBacteriaiCAG44653; CAG44653; FTT_0020.
    GeneIDi3191915.
    KEGGiftu:FTT_0020.
    PATRICi17962991. VBIFraTul2086_0023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG44653.1 .
    RefSeqi YP_169096.1. NC_006570.2.

    3D structure databases

    ProteinModelPortali Q5NIP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5NIP6. 15 interactions.
    STRINGi 177416.FTT_0020.

    Protocols and materials databases

    DNASUi 3191915.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG44653 ; CAG44653 ; FTT_0020 .
    GeneIDi 3191915.
    KEGGi ftu:FTT_0020.
    PATRICi 17962991. VBIFraTul2086_0023.

    Phylogenomic databases

    eggNOGi COG0154.
    HOGENOMi HOG000116699.
    KOi K02433.
    OMAi GKPFAEE.
    OrthoDBi EOG61P6R9.

    Enzyme and pathway databases

    BioCyci FTUL177416:GNBP-20-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    HAMAPi MF_00120. GatA.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 1 hit.
    TIGRFAMsi TIGR00132. gatA. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCHU S4 / Schu 4.

    Entry informationi

    Entry nameiGATA_FRATT
    AccessioniPrimary (citable) accession number: Q5NIP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3