Q5NID9 (EFTU_FRATT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor Tu
Short name=EF-Tu

Gene names

Name:	tuf
Ordered Locus Names:	FTT_0137

Organism

Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [Reference proteome] [HAMAP]

Taxonomic identifier

177416 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella tularensis subsp. tularensis

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Elongation factor Tu HAMAP-Rule MF_00118		PRO_1000015664
Regions
	Nucleotide binding	19 – 26	8	GTP By similarity
	Nucleotide binding	81 – 85	5	GTP By similarity
	Nucleotide binding	136 – 139	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5NID9 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 53C103C67BE3ACFE	FASTA	394	43,405
	10 20 30 40 50 60 MAKEKFERSK PHVNVGTIGH VDHGKTTLTA AITKVMAEKN GGMARKFDEI DSAPEEKARG 70 80 90 100 110 120 ITINTSHVEY ESPNRHYAHV DCPGHADYVK NMITGAAQMD GAILVCSAAD GPMPQTREHI 130 140 150 160 170 180 LLSRQVGVPK IVVFLNKCDM VDDEELLELV EMEVRELLDQ YEFPGDDTPV IMGSALRAIE 190 200 210 220 230 240 GDEAYVEKIV ELVQAMDDYI PAPERDTEKP FILPIEDVFS ISGRGTVVTG RIERGVVNIG 250 260 270 280 290 300 DEVEVVGIRP TQKTTVTGVE MFRKLLDRGE AGDNVGILVR GLKRDDVERG QVLCKPGSIK 310 320 330 340 350 360 PHTKFEAEVY VLSKEEGGRH TPFFKGYRPQ FYFRTTDITG AVELPEGVEM VMPGDNVKMT 370 380 390 ITLINPIAMD EGLRFAIREG GRTVGAGVVA KIIE

References

[1]

"The complete genome sequence of Francisella tularensis, the causative agent of tularemia." Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H., Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D., Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S., Sjoestedt A. , Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W., Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W. Nat. Genet. 37:153-159(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCHU S4 / Schu 4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ749949 Genomic DNA. Translation: CAG44770.1.
RefSeq	YP_169203.1. NC_006570.2.
3D structure databases
HSSP	HSSP built from PDB template 1XB2 based on UniProtKB P49410.
ProteinModelPortal	Q5NID9.
SMR	Q5NID9. Positions 2-393.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5NID9. 11 interactions.
STRING	177416.FTT_0137.
Protocols and materials databases
DNASU	3190712.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG44770; CAG44770; FTT_0137.
GeneID	3190712.
KEGG	ftu:FTT_0137.
PATRIC	17963262. VBIFraTul2086_0153.
Phylogenomic databases
eggNOG	COG0050.
HOGENOM	HOG000229290.
KO	K02358.
OMA	CEFVGYN.
ProtClustDB	PRK12735.
Family and domain databases
HAMAP	MF_00118_B. EF_Tu_B.
InterPro	IPR000795. EF_GTP-bd_dom. IPR005225. Small_GTP-bd_dom. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004161. Transl_elong_EFTu/EF1A_2. IPR004541. Transl_elong_EFTu/EF1A_bac/org. IPR004160. Transl_elong_EFTu/EF1A_C. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF50465. Elong_init_C. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00485. EF-Tu. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFTU_FRATT

Accession

Primary (citable) accession number: Q5NID9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program