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Q5NHQ9

- GLMS_FRATT

UniProt

Q5NHQ9 - GLMS_FRATT

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei607 – 6071For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciFTUL177416:GNBP-396-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:FTT_0388
    OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
    Taxonomic identifieri177416 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001174: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 612611Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135332Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ5NHQ9. 2 interactions.
    STRINGi177416.FTT_0388.

    Structurei

    Secondary structure

    1
    612
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi253 – 2597
    Helixi261 – 27010
    Helixi280 – 2823
    Helixi287 – 2926
    Beta strandi296 – 3016
    Helixi303 – 31816
    Beta strandi324 – 3285
    Helixi329 – 3324
    Beta strandi343 – 35210
    Helixi355 – 36410
    Turni365 – 3684
    Beta strandi369 – 38113
    Helixi382 – 3865
    Beta strandi387 – 3926
    Beta strandi400 – 4023
    Helixi405 – 42420
    Helixi430 – 44112
    Helixi443 – 4519
    Helixi454 – 4618
    Helixi462 – 4643
    Beta strandi469 – 4746
    Helixi478 – 49316
    Beta strandi496 – 5016
    Helixi502 – 5043
    Turni505 – 5128
    Beta strandi518 – 5236
    Helixi529 – 54113
    Beta strandi545 – 5517
    Helixi552 – 5576
    Beta strandi564 – 5685
    Helixi575 – 59521

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TBFX-ray2.28A/B/C/D/E/F/G/H241-612[»]
    ProteinModelPortaliQ5NHQ9.
    SMRiQ5NHQ9. Positions 2-612.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini287 – 427141SIS 1UniRule annotationAdd
    BLAST
    Domaini460 – 602143SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NHQ9-1 [UniParc]FASTAAdd to Basket

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    MCGIVGANST RNVTNILIEG LKKLEYRGYD SAGLAIIDDK NNIDICKEVG    50
    KVIELEKSVH NLANFKGDIG IAHTRWATHG KPSKNNSHPH ASESFCIVHN 100
    GVIENFAELK KVLINDGYKF KSDTDTEVIA HLLQKEWRDN FSIVDNIKYI 150
    MAMLKGAYAV AIISQKFSDK IVAVRSGSPL VIGVGIDENF ISSDALSLLP 200
    VTNKFSYLDE GDIAIISKDN VEVFDNNGAA KNLEVEEYNY SSSSASKDGY 250
    KHYMLKEIYE QPEAVSNTIL ASLADGEISL DSFDKRAKEL FEKTKHICIV 300
    ACGTSYNAGM TAKYWIEKYA KVPCSVEIAS EIRYRDNVVV DGSLFVSISQ 350
    SGETADTLES LRKSKKQNYV GSMCICNVPN SSLVRESDIA FMTKAGVEIG 400
    VASTKAFTTQ LVALAIFTLV IAKLKNSLTD QQIAKYTEEL KNIRALVMGA 450
    LKLDTEIDQI SEYFSDKEHT IFLGRGLYYP IAIEGALKLK EISYIHAEAY 500
    PSGELKHGPL ALVDKNMPIV AVVPNDELLD KTLSNLQEVH ARGGKLILFV 550
    DKAVKERVNF DNSIVLELDA GHDFSAPVVF TIPLQLLSYH VAIIKGTDVD 600
    QPRNLAKSVT VE 612
    Length:612
    Mass (Da):67,444
    Last modified:January 23, 2007 - v3
    Checksum:i5B358856A65E7245
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG45021.1.
    RefSeqiYP_169433.1. NC_006570.2.

    Genome annotation databases

    EnsemblBacteriaiCAG45021; CAG45021; FTT_0388.
    GeneIDi3192352.
    KEGGiftu:FTT_0388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG45021.1 .
    RefSeqi YP_169433.1. NC_006570.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TBF X-ray 2.28 A/B/C/D/E/F/G/H 241-612 [» ]
    ProteinModelPortali Q5NHQ9.
    SMRi Q5NHQ9. Positions 2-612.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5NHQ9. 2 interactions.
    STRINGi 177416.FTT_0388.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    DNASUi 3192352.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG45021 ; CAG45021 ; FTT_0388 .
    GeneIDi 3192352.
    KEGGi ftu:FTT_0388.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci FTUL177416:GNBP-396-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCHU S4 / Schu 4.

    Entry informationi

    Entry nameiGLMS_FRATT
    AccessioniPrimary (citable) accession number: Q5NHQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3