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Q5NHQ9

- GLMS_FRATT

UniProt

Q5NHQ9 - GLMS_FRATT

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei607 – 6071For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-396-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:FTT_0388
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 612611Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135332Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ5NHQ9. 2 interactions.
STRINGi177416.FTT_0388.

Structurei

Secondary structure

1
612
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi253 – 2597
Helixi261 – 27010
Helixi280 – 2823
Helixi287 – 2926
Beta strandi296 – 3016
Helixi303 – 31816
Beta strandi324 – 3285
Helixi329 – 3324
Beta strandi343 – 35210
Helixi355 – 36410
Turni365 – 3684
Beta strandi369 – 38113
Helixi382 – 3865
Beta strandi387 – 3926
Beta strandi400 – 4023
Helixi405 – 42420
Helixi430 – 44112
Helixi443 – 4519
Helixi454 – 4618
Helixi462 – 4643
Beta strandi469 – 4746
Helixi478 – 49316
Beta strandi496 – 5016
Helixi502 – 5043
Turni505 – 5128
Beta strandi518 – 5236
Helixi529 – 54113
Beta strandi545 – 5517
Helixi552 – 5576
Beta strandi564 – 5685
Helixi575 – 59521

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TBFX-ray2.28A/B/C/D/E/F/G/H241-612[»]
ProteinModelPortaliQ5NHQ9.
SMRiQ5NHQ9. Positions 2-612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini287 – 427141SIS 1UniRule annotationAdd
BLAST
Domaini460 – 602143SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NHQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGANST RNVTNILIEG LKKLEYRGYD SAGLAIIDDK NNIDICKEVG
60 70 80 90 100
KVIELEKSVH NLANFKGDIG IAHTRWATHG KPSKNNSHPH ASESFCIVHN
110 120 130 140 150
GVIENFAELK KVLINDGYKF KSDTDTEVIA HLLQKEWRDN FSIVDNIKYI
160 170 180 190 200
MAMLKGAYAV AIISQKFSDK IVAVRSGSPL VIGVGIDENF ISSDALSLLP
210 220 230 240 250
VTNKFSYLDE GDIAIISKDN VEVFDNNGAA KNLEVEEYNY SSSSASKDGY
260 270 280 290 300
KHYMLKEIYE QPEAVSNTIL ASLADGEISL DSFDKRAKEL FEKTKHICIV
310 320 330 340 350
ACGTSYNAGM TAKYWIEKYA KVPCSVEIAS EIRYRDNVVV DGSLFVSISQ
360 370 380 390 400
SGETADTLES LRKSKKQNYV GSMCICNVPN SSLVRESDIA FMTKAGVEIG
410 420 430 440 450
VASTKAFTTQ LVALAIFTLV IAKLKNSLTD QQIAKYTEEL KNIRALVMGA
460 470 480 490 500
LKLDTEIDQI SEYFSDKEHT IFLGRGLYYP IAIEGALKLK EISYIHAEAY
510 520 530 540 550
PSGELKHGPL ALVDKNMPIV AVVPNDELLD KTLSNLQEVH ARGGKLILFV
560 570 580 590 600
DKAVKERVNF DNSIVLELDA GHDFSAPVVF TIPLQLLSYH VAIIKGTDVD
610
QPRNLAKSVT VE
Length:612
Mass (Da):67,444
Last modified:January 23, 2007 - v3
Checksum:i5B358856A65E7245
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45021.1.
RefSeqiYP_169433.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45021; CAG45021; FTT_0388.
GeneIDi3192352.
KEGGiftu:FTT_0388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45021.1 .
RefSeqi YP_169433.1. NC_006570.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TBF X-ray 2.28 A/B/C/D/E/F/G/H 241-612 [» ]
ProteinModelPortali Q5NHQ9.
SMRi Q5NHQ9. Positions 2-612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5NHQ9. 2 interactions.
STRINGi 177416.FTT_0388.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

DNASUi 3192352.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG45021 ; CAG45021 ; FTT_0388 .
GeneIDi 3192352.
KEGGi ftu:FTT_0388.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci FTUL177416:GNBP-396-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiGLMS_FRATT
AccessioniPrimary (citable) accession number: Q5NHQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3