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Q5NHN8

- GCSPA_FRATT

UniProt

Q5NHN8 - GCSPA_FRATT

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, FTT_0409
Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:FTT_0409
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000045654Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

IntActiQ5NHN8. 3 interactions.
STRINGi177416.FTT_0409.

Structurei

3D structure databases

ProteinModelPortaliQ5NHN8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NHN8-1 [UniParc]FASTAAdd to Basket

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MSFIPHKLEQ IKKMLDTIGA SSVDQLFDEI PRHLRADTLK IKDGINEIQL    50
ANLMRKRANK NHHNINYIGA GAYSHHIPAA IWDIVARGEF YTAYTPYQAE 100
ASQGGLQVIY EFQTMMAGLT GMDASNASMY DGATALAESV LMAIRSNKKA 150
KSQKVLIAEA LHPTYLRVLE TITKHQGIEF DIVNLDSKNG KTDVTKLEDF 200
ANTNYAAVVI QSPNFLGQLA DVDGITNWAH KHGALVIAVT NPMSLAILKS 250
PAEWGDNGAD IVCGEGQPMG VPLASGGPYF GFMTCKMAHV RQMPGRIVGR 300
TVDLDGNEGF CLTLQAREQH IRRAKATSNI CTNQGLMVTA ATIYMSLLGA 350
EGLERVASIS HENTQTLATE LAKINGVSIR FNSAFFNEVV IDLPVNAETF 400
VTEMEKEAID AGYFLGEYHS DLANSIMVCA TEIHTSEDIK EYIEATKKVL 450
ARIGG 455
Length:455
Mass (Da):49,699
Last modified:February 1, 2005 - v1
Checksum:i0196338700D98186
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45042.1.
RefSeqiYP_169454.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45042; CAG45042; FTT_0409.
GeneIDi3192502.
KEGGiftu:FTT_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45042.1 .
RefSeqi YP_169454.1. NC_006570.2.

3D structure databases

ProteinModelPortali Q5NHN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5NHN8. 3 interactions.
STRINGi 177416.FTT_0409.

Protocols and materials databases

DNASUi 3192502.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG45042 ; CAG45042 ; FTT_0409 .
GeneIDi 3192502.
KEGGi ftu:FTT_0409.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci FTUL177416:GNBP-418-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiGCSPA_FRATT
AccessioniPrimary (citable) accession number: Q5NHN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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