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Q5NHN8

- GCSPA_FRATT

UniProt

Q5NHN8 - GCSPA_FRATT

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:FTT_0409
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045654Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

IntActiQ5NHN8. 3 interactions.
STRINGi177416.FTT_0409.

Structurei

3D structure databases

ProteinModelPortaliQ5NHN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NHN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFIPHKLEQ IKKMLDTIGA SSVDQLFDEI PRHLRADTLK IKDGINEIQL
60 70 80 90 100
ANLMRKRANK NHHNINYIGA GAYSHHIPAA IWDIVARGEF YTAYTPYQAE
110 120 130 140 150
ASQGGLQVIY EFQTMMAGLT GMDASNASMY DGATALAESV LMAIRSNKKA
160 170 180 190 200
KSQKVLIAEA LHPTYLRVLE TITKHQGIEF DIVNLDSKNG KTDVTKLEDF
210 220 230 240 250
ANTNYAAVVI QSPNFLGQLA DVDGITNWAH KHGALVIAVT NPMSLAILKS
260 270 280 290 300
PAEWGDNGAD IVCGEGQPMG VPLASGGPYF GFMTCKMAHV RQMPGRIVGR
310 320 330 340 350
TVDLDGNEGF CLTLQAREQH IRRAKATSNI CTNQGLMVTA ATIYMSLLGA
360 370 380 390 400
EGLERVASIS HENTQTLATE LAKINGVSIR FNSAFFNEVV IDLPVNAETF
410 420 430 440 450
VTEMEKEAID AGYFLGEYHS DLANSIMVCA TEIHTSEDIK EYIEATKKVL

ARIGG
Length:455
Mass (Da):49,699
Last modified:February 1, 2005 - v1
Checksum:i0196338700D98186
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45042.1.
RefSeqiYP_169454.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45042; CAG45042; FTT_0409.
GeneIDi3192502.
KEGGiftu:FTT_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45042.1 .
RefSeqi YP_169454.1. NC_006570.2.

3D structure databases

ProteinModelPortali Q5NHN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5NHN8. 3 interactions.
STRINGi 177416.FTT_0409.

Protocols and materials databases

DNASUi 3192502.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG45042 ; CAG45042 ; FTT_0409 .
GeneIDi 3192502.
KEGGi ftu:FTT_0409.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci FTUL177416:GNBP-418-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiGCSPA_FRATT
AccessioniPrimary (citable) accession number: Q5NHN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3