Q5NGI4 (UBIA_FRATT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxybenzoate octaprenyltransferase
EC=2.5.1.-

Alternative name(s):
4-HB polyprenyltransferase

Gene names

Name:	ubiA
Ordered Locus Names:	FTT_0856c

Organism

Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [Reference proteome] [HAMAP]

Taxonomic identifier

177416 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella tularensis subsp. tularensis

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesis of 3-octaprenyl-4-hydroxybenzoate By similarity. HAMAP-Rule MF_01635
Catalytic activity	4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate. HAMAP-Rule MF_01635
Cofactor	Magnesium By similarity. HAMAP-Rule MF_01635
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01635
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01635.
Sequence similarities	Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	4-hydroxybenzoate octaprenyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	4-hydroxybenzoate octaprenyltransferase HAMAP-Rule MF_01635		PRO_0000262797
Regions
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	107 – 127	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	211 – 231	21	Helical; Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Transmembrane	261 – 281	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5NGI4 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 31B73AF6BB804F15	FASTA	284	32,489
	10 20 30 40 50 60 MNKQQLKAYF MLMRLHRPIP ILLILWPTLT ALVLASHGLP DISYLVIFTI GVVVMRTVGC 70 80 90 100 110 120 IINDIADVDF DKHVARTNTR PLTSGQLSIK NAIWLCISLT LVAFICVLFL NLYTILLSFV 130 140 150 160 170 180 ALFLAILYPF CKRFFAIPQL ILGLAFNFGI FMAFSTIQNQ IPVEAWIFYI ATICWTIAYD 190 200 210 220 230 240 TIYALADREF DLEIGIKSSA VLFGNKVFRY ILLFNFLSLL LLIILGIYCD FNSFFYLGVV 250 260 270 280 ICSLFFVRNY FLYKKLGITN CINAFSANHW IGLIIFIIAV IQYI

References

[1]

"The complete genome sequence of Francisella tularensis, the causative agent of tularemia." Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H., Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D., Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S., Sjoestedt A. , Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W., Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W. Nat. Genet. 37:153-159(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCHU S4 / Schu 4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ749949 Genomic DNA. Translation: CAG45489.1.
RefSeq	YP_169858.1. NC_006570.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	177416.FTT_0856c.
Protocols and materials databases
DNASU	3192470.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG45489; CAG45489; FTT_0856c.
GeneID	3192470.
KEGG	ftu:FTT_0856c.
Phylogenomic databases
eggNOG	COG0382.
HOGENOM	HOG000003696.
KO	K03179.
OMA	YHYTLIR.
ProtClustDB	PRK12847.
Enzyme and pathway databases
UniPathway	UPA00232.
Family and domain databases
HAMAP	MF_01635. UbiA.
InterPro	IPR006370. HB_polyprenyl-transferase. IPR000537. UbiA_prenyltransferase. [Graphical view]
Pfam	PF01040. UbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01474. ubiA_proteo. 1 hit.
PROSITE	PS00943. UBIA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIA_FRATT

Accession

Primary (citable) accession number: Q5NGI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program