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Protein

4-hydroxybenzoate octaprenyltransferase

Gene

ubiA

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.UniRule annotation

Catalytic activityi

4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate octaprenyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
4-HB polyprenyltransferaseUniRule annotation
Gene namesi
Name:ubiAUniRule annotation
Ordered Locus Names:FTT_0856c
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001174 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalUniRule annotationAdd BLAST21
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei107 – 127HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21
Transmembranei211 – 231HelicalUniRule annotationAdd BLAST21
Transmembranei233 – 253HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002627971 – 2844-hydroxybenzoate octaprenyltransferaseAdd BLAST284

Interactioni

Protein-protein interaction databases

STRINGi177416.FTT_0856c.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C4G. Bacteria.
COG0382. LUCA.
HOGENOMiHOG000003696.
KOiK03179.
OMAiILSICWG.

Family and domain databases

HAMAPiMF_01635. UbiA. 1 hit.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NGI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQQLKAYF MLMRLHRPIP ILLILWPTLT ALVLASHGLP DISYLVIFTI
60 70 80 90 100
GVVVMRTVGC IINDIADVDF DKHVARTNTR PLTSGQLSIK NAIWLCISLT
110 120 130 140 150
LVAFICVLFL NLYTILLSFV ALFLAILYPF CKRFFAIPQL ILGLAFNFGI
160 170 180 190 200
FMAFSTIQNQ IPVEAWIFYI ATICWTIAYD TIYALADREF DLEIGIKSSA
210 220 230 240 250
VLFGNKVFRY ILLFNFLSLL LLIILGIYCD FNSFFYLGVV ICSLFFVRNY
260 270 280
FLYKKLGITN CINAFSANHW IGLIIFIIAV IQYI
Length:284
Mass (Da):32,489
Last modified:February 1, 2005 - v1
Checksum:i31B73AF6BB804F15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45489.1.
RefSeqiWP_003020835.1. NZ_CP010290.1.
YP_169858.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45489; CAG45489; FTT_0856c.
GeneIDi3192470.
KEGGiftu:FTT_0856c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45489.1.
RefSeqiWP_003020835.1. NZ_CP010290.1.
YP_169858.1. NC_006570.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi177416.FTT_0856c.

Protocols and materials databases

DNASUi3192470.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG45489; CAG45489; FTT_0856c.
GeneIDi3192470.
KEGGiftu:FTT_0856c.

Phylogenomic databases

eggNOGiENOG4105C4G. Bacteria.
COG0382. LUCA.
HOGENOMiHOG000003696.
KOiK03179.
OMAiILSICWG.

Enzyme and pathway databases

UniPathwayiUPA00232.

Family and domain databases

HAMAPiMF_01635. UbiA. 1 hit.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBIA_FRATT
AccessioniPrimary (citable) accession number: Q5NGI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.