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Q5NGI4 (UBIA_FRATT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxybenzoate octaprenyltransferase

EC=2.5.1.-
Alternative name(s):
4-HB polyprenyltransferase
Gene names
Name:ubiA
Ordered Locus Names:FTT_0856c
OrganismFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [Reference proteome] [HAMAP]
Taxonomic identifier177416 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Synthesis of 3-octaprenyl-4-hydroxybenzoate By similarity. HAMAP-Rule MF_01635

Catalytic activity

4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate. HAMAP-Rule MF_01635

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01635

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01635

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01635.

Sequence similarities

Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
   Biological processUbiquinone biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprenyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2842844-hydroxybenzoate octaprenyltransferase HAMAP-Rule MF_01635
PRO_0000262797

Regions

Transmembrane42 – 6221Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane233 – 25321Helical; Potential
Transmembrane261 – 28121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5NGI4 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 31B73AF6BB804F15

FASTA28432,489
        10         20         30         40         50         60 
MNKQQLKAYF MLMRLHRPIP ILLILWPTLT ALVLASHGLP DISYLVIFTI GVVVMRTVGC 

        70         80         90        100        110        120 
IINDIADVDF DKHVARTNTR PLTSGQLSIK NAIWLCISLT LVAFICVLFL NLYTILLSFV 

       130        140        150        160        170        180 
ALFLAILYPF CKRFFAIPQL ILGLAFNFGI FMAFSTIQNQ IPVEAWIFYI ATICWTIAYD 

       190        200        210        220        230        240 
TIYALADREF DLEIGIKSSA VLFGNKVFRY ILLFNFLSLL LLIILGIYCD FNSFFYLGVV 

       250        260        270        280 
ICSLFFVRNY FLYKKLGITN CINAFSANHW IGLIIFIIAV IQYI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ749949 Genomic DNA. Translation: CAG45489.1.
RefSeqYP_169858.1. NC_006570.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177416.FTT_0856c.

Protocols and materials databases

DNASU3192470.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG45489; CAG45489; FTT_0856c.
GeneID3192470.
KEGGftu:FTT_0856c.

Phylogenomic databases

eggNOGCOG0382.
HOGENOMHOG000003696.
KOK03179.
OMAGMPMAFT.
OrthoDBEOG680X3B.

Enzyme and pathway databases

BioCycFTUL177416:GNBP-873-MONOMER.
UniPathwayUPA00232.

Family and domain databases

HAMAPMF_01635. UbiA.
InterProIPR006370. HB_polyprenyl-transferase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01474. ubiA_proteo. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIA_FRATT
AccessionPrimary (citable) accession number: Q5NGI4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways