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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-941-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
Including the following 2 domains:
23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
Gene namesi
Name:rlmLUniRule annotation
Ordered Locus Names:FTT_0923
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001174 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Ribosomal RNA large subunit methyltransferase K/LPRO_0000366756Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ5NGC3. 3 interactions.
STRINGi177416.FTT_0923.

Structurei

3D structure databases

ProteinModelPortaliQ5NGC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 155112THUMPUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
Contains 1 THUMP domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4H. Bacteria.
COG0116. LUCA.
COG1092. LUCA.
HOGENOMiHOG000218371.
KOiK12297.
OMAiMSNTYLN.
OrthoDBiEOG6HJ238.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NGC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKFTFFVSC AKGIELLLKD ELERLGISSQ EKLAGVEFEG SIKDAYKVCI
60 70 80 90 100
YSYLASQVML KVATDKVINQ QDLYEFISSI NWMDYFAVDK TFKIIISGKH
110 120 130 140 150
YDFNNTMFVS QKTKDAIVDQ FRNVTNQRPN IDTENPDNVI KLHLHKQFVN
160 170 180 190 200
VFLCLNIDSL HKRSYRQFQG QAPLKESLAA AILIKAGWLE ELKKHQPILI
210 220 230 240 250
DPMCGSGTIL IEAALMAKNI APVLLNKEFK IFNSKFHNQE LWDNLLEIAK
260 270 280 290 300
NSQKVTNAII CGFDIDNNVL DKAQRNIYQA GVEDVITVKR QDIRDLENEF
310 320 330 340 350
ESEGLIVTNP PYGERLYGDQ LDELLDIFNG FGNRLSQDFY GWKVAVLTSF
360 370 380 390 400
ADSIKEMQLR TTERNKFYNG AIETILYQFE INEHAKFKHE TQLEKNIRIA
410 420 430 440 450
EASAQKSDEH IDFANKLKKN LKSLKPWLKQ TGLECYRLYD ADIPTFAVAV
460 470 480 490 500
DVYSEHIFLQ EYRADATIDQ NIAKQRFYQA IYQIHKTLDI KYENIHTRVR
510 520 530 540 550
QRQKGKEQYQ KENDKNKFHI INEFDAKFYV NFDDYLDTGI FLDHRKIRQL
560 570 580 590 600
VAKAAKNKTL LNLFSYTCTA SVHAALKGAK TTSVDMSNTY LEWGKNNFTL
610 620 630 640 650
NNIDAKKHSF IQADCISWLK TNKDKFDVIF LDPPTFSNSK RMDDILDIQR
660 670 680 690 700
DHELLINLAM DSLKKDGILY FSNNYRRFKM SPQILEKFNC ENIDKICLSR
710
DFLSNKNIHN CWEIKYK
Length:717
Mass (Da):83,483
Last modified:February 1, 2005 - v1
Checksum:iF2705792DB8B92AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45556.1.
RefSeqiWP_003020954.1. NZ_CP010290.1.
YP_169919.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45556; CAG45556; FTT_0923.
GeneIDi3192468.
KEGGiftu:FTT_0923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45556.1.
RefSeqiWP_003020954.1. NZ_CP010290.1.
YP_169919.1. NC_006570.2.

3D structure databases

ProteinModelPortaliQ5NGC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5NGC3. 3 interactions.
STRINGi177416.FTT_0923.

Protocols and materials databases

DNASUi3192468.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG45556; CAG45556; FTT_0923.
GeneIDi3192468.
KEGGiftu:FTT_0923.

Phylogenomic databases

eggNOGiENOG4105C4H. Bacteria.
COG0116. LUCA.
COG1092. LUCA.
HOGENOMiHOG000218371.
KOiK12297.
OMAiMSNTYLN.
OrthoDBiEOG6HJ238.

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-941-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiRLMKL_FRATT
AccessioniPrimary (citable) accession number: Q5NGC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 1, 2005
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.