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Q5NFM5

- RPIA_FRATT

UniProt

Q5NFM5 - RPIA_FRATT

Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

    Catalytic activityi

    D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei109 – 1091Proton acceptorCurated
    Binding sitei127 – 1271Substrate2 PublicationsUniRule annotation

    GO - Molecular functioni

    1. ribose-5-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt, non-oxidative branch Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciFTUL177416:GNBP-1226-MONOMER.
    UniPathwayiUPA00115; UER00412.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
    Alternative name(s):
    Phosphoriboisomerase AUniRule annotation
    Short name:
    PRIUniRule annotation
    Gene namesi
    Name:rpiAUniRule annotation
    Ordered Locus Names:FTT_1208
    OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
    Taxonomic identifieri177416 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001174: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Ribose-5-phosphate isomerase APRO_0000158419Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer and homotetramer.2 PublicationsUniRule annotation

    Protein-protein interaction databases

    STRINGi177416.FTT_1208.

    Structurei

    Secondary structure

    1
    224
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi8 – 2114
    Beta strandi26 – 327
    Helixi36 – 449
    Helixi45 – 484
    Turni49 – 513
    Beta strandi52 – 587
    Helixi60 – 689
    Helixi76 – 794
    Beta strandi81 – 877
    Beta strandi90 – 923
    Beta strandi102 – 1043
    Helixi106 – 1149
    Beta strandi119 – 1246
    Helixi125 – 1273
    Beta strandi130 – 1323
    Beta strandi137 – 1415
    Helixi143 – 1453
    Helixi146 – 15611
    Beta strandi159 – 1624
    Beta strandi173 – 1797
    Helixi185 – 1939
    Beta strandi198 – 2047
    Beta strandi210 – 2167
    Turni217 – 2193
    Beta strandi220 – 2245

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KWMX-ray2.32A/B/C/D1-224[»]
    4IO1X-ray1.65A/B1-224[»]
    ProteinModelPortaliQ5NFM5.
    SMRiQ5NFM5. Positions 8-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 374Substrate bindingCurated
    Regioni87 – 904Substrate bindingUniRule annotation
    Regioni100 – 1034Substrate bindingCurated

    Sequence similaritiesi

    Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0120.
    HOGENOMiHOG000276368.
    KOiK01807.
    OMAiMDQLEMK.
    OrthoDBiEOG67MF61.

    Family and domain databases

    HAMAPiMF_00170. Rib_5P_isom_A.
    InterProiIPR004788. Ribose5P_isomerase_typA.
    IPR020672. Ribose5P_isomerase_typA_subgr.
    [Graphical view]
    PANTHERiPTHR11934. PTHR11934. 1 hit.
    PfamiPF06026. Rib_5-P_isom_A. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00021. rpiA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5NFM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFNKKNNQD ELKKLAATEA AKSITTEITL GVGTGSTVGF LIEELVNYRD    50
    KIKTVVSSSE DSTRKLKALG FDVVDLNYAG EIDLYIDGAD ECNNHKELIK 100
    GGGAALTREK ICVAAAKKFI CIIDESKKVN TLGNFPLPIE VIPMARSYIA 150
    RQIVKLGGQP VYREQTITDN GNVILDVYNL KIDNPLKLET ELNQITGVVT 200
    NGIFALKPAD TVIMATKDSN IVVL 224
    Length:224
    Mass (Da):24,466
    Last modified:February 1, 2005 - v1
    Checksum:i46ACC58D7487CC2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG45841.1.
    RefSeqiYP_170167.1. NC_006570.2.

    Genome annotation databases

    EnsemblBacteriaiCAG45841; CAG45841; FTT_1208.
    GeneIDi3192024.
    KEGGiftu:FTT_1208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG45841.1 .
    RefSeqi YP_170167.1. NC_006570.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KWM X-ray 2.32 A/B/C/D 1-224 [» ]
    4IO1 X-ray 1.65 A/B 1-224 [» ]
    ProteinModelPortali Q5NFM5.
    SMRi Q5NFM5. Positions 8-219.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177416.FTT_1208.

    Protocols and materials databases

    DNASUi 3192024.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG45841 ; CAG45841 ; FTT_1208 .
    GeneIDi 3192024.
    KEGGi ftu:FTT_1208.

    Phylogenomic databases

    eggNOGi COG0120.
    HOGENOMi HOG000276368.
    KOi K01807.
    OMAi MDQLEMK.
    OrthoDBi EOG67MF61.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00412 .
    BioCyci FTUL177416:GNBP-1226-MONOMER.

    Family and domain databases

    HAMAPi MF_00170. Rib_5P_isom_A.
    InterProi IPR004788. Ribose5P_isomerase_typA.
    IPR020672. Ribose5P_isomerase_typA_subgr.
    [Graphical view ]
    PANTHERi PTHR11934. PTHR11934. 1 hit.
    Pfami PF06026. Rib_5-P_isom_A. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00021. rpiA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCHU S4 / Schu 4.
    2. "Crystal structure of ribose-5-isomerase A."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Orlikowska M., Rostankowski R., Nakka C., Hattne J., Grimshaw S., Borek D., Otwinowski Z.
      Submitted (DEC-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.
    3. "Structural and biophysical studies of Ribose-5-Phosphate Isomerase A from Francisella tularensis."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Rostankowski R., Orlikowska M., Nakka C., Grimshaw S., Borek D., Otwinowski Z.
      Submitted (JAN-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.

    Entry informationi

    Entry nameiRPIA_FRATT
    AccessioniPrimary (citable) accession number: Q5NFM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3