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Q5NFM5

- RPIA_FRATT

UniProt

Q5NFM5 - RPIA_FRATT

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Protein

Ribose-5-phosphate isomerase A

Gene
rpiA, FTT_1208
Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate By similarity.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091Proton acceptor Inferred
Binding sitei127 – 1271Substrate

GO - Molecular functioni

  1. ribose-5-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt, non-oxidative branch Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-1226-MONOMER.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase A (EC:5.3.1.6)
Alternative name(s):
Phosphoriboisomerase A
Short name:
PRI
Gene namesi
Name:rpiA
Ordered Locus Names:FTT_1208
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Ribose-5-phosphate isomerase AUniRule annotationPRO_0000158419Add
BLAST

Interactioni

Subunit structurei

Homodimer and homotetramer.2 Publications

Protein-protein interaction databases

STRINGi177416.FTT_1208.

Structurei

Secondary structure

1
224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 2114
Beta strandi26 – 327
Helixi36 – 449
Helixi45 – 484
Turni49 – 513
Beta strandi52 – 587
Helixi60 – 689
Helixi76 – 794
Beta strandi81 – 877
Beta strandi90 – 923
Beta strandi102 – 1043
Helixi106 – 1149
Beta strandi119 – 1246
Helixi125 – 1273
Beta strandi130 – 1323
Beta strandi137 – 1415
Helixi143 – 1453
Helixi146 – 15611
Beta strandi159 – 1624
Beta strandi173 – 1797
Helixi185 – 1939
Beta strandi198 – 2047
Beta strandi210 – 2167
Turni217 – 2193
Beta strandi220 – 2245

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KWMX-ray2.32A/B/C/D1-224[»]
4IO1X-ray1.65A/B1-224[»]
ProteinModelPortaliQ5NFM5.
SMRiQ5NFM5. Positions 8-219.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 374Substrate binding Inferred
Regioni87 – 904Substrate binding By similarity
Regioni100 – 1034Substrate binding Inferred

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0120.
HOGENOMiHOG000276368.
KOiK01807.
OMAiMDQLEMK.
OrthoDBiEOG67MF61.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NFM5-1 [UniParc]FASTAAdd to Basket

« Hide

MFFNKKNNQD ELKKLAATEA AKSITTEITL GVGTGSTVGF LIEELVNYRD    50
KIKTVVSSSE DSTRKLKALG FDVVDLNYAG EIDLYIDGAD ECNNHKELIK 100
GGGAALTREK ICVAAAKKFI CIIDESKKVN TLGNFPLPIE VIPMARSYIA 150
RQIVKLGGQP VYREQTITDN GNVILDVYNL KIDNPLKLET ELNQITGVVT 200
NGIFALKPAD TVIMATKDSN IVVL 224
Length:224
Mass (Da):24,466
Last modified:February 1, 2005 - v1
Checksum:i46ACC58D7487CC2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45841.1.
RefSeqiYP_170167.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45841; CAG45841; FTT_1208.
GeneIDi3192024.
KEGGiftu:FTT_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45841.1 .
RefSeqi YP_170167.1. NC_006570.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KWM X-ray 2.32 A/B/C/D 1-224 [» ]
4IO1 X-ray 1.65 A/B 1-224 [» ]
ProteinModelPortali Q5NFM5.
SMRi Q5NFM5. Positions 8-219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177416.FTT_1208.

Protocols and materials databases

DNASUi 3192024.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG45841 ; CAG45841 ; FTT_1208 .
GeneIDi 3192024.
KEGGi ftu:FTT_1208.

Phylogenomic databases

eggNOGi COG0120.
HOGENOMi HOG000276368.
KOi K01807.
OMAi MDQLEMK.
OrthoDBi EOG67MF61.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00412 .
BioCyci FTUL177416:GNBP-1226-MONOMER.

Family and domain databases

HAMAPi MF_00170. Rib_5P_isom_A.
InterProi IPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view ]
PANTHERi PTHR11934. PTHR11934. 1 hit.
Pfami PF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00021. rpiA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.
  2. "Crystal structure of ribose-5-isomerase A."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Orlikowska M., Rostankowski R., Nakka C., Hattne J., Grimshaw S., Borek D., Otwinowski Z.
    Submitted (DEC-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.
  3. "Structural and biophysical studies of Ribose-5-Phosphate Isomerase A from Francisella tularensis."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Rostankowski R., Orlikowska M., Nakka C., Grimshaw S., Borek D., Otwinowski Z.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.

Entry informationi

Entry nameiRPIA_FRATT
AccessioniPrimary (citable) accession number: Q5NFM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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