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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA), Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109Proton acceptorCurated1
Binding sitei127SubstrateUniRule annotation2 Publications1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:FTT_1208
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001174 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001584191 – 224Ribose-5-phosphate isomerase AAdd BLAST224

Interactioni

Subunit structurei

Homodimer and homotetramer.UniRule annotation2 Publications

Protein-protein interaction databases

STRINGi177416.FTT_1208.

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 21Combined sources14
Beta strandi26 – 32Combined sources7
Helixi36 – 44Combined sources9
Helixi45 – 48Combined sources4
Turni49 – 51Combined sources3
Beta strandi52 – 58Combined sources7
Helixi60 – 68Combined sources9
Helixi76 – 79Combined sources4
Beta strandi81 – 87Combined sources7
Beta strandi90 – 92Combined sources3
Beta strandi102 – 104Combined sources3
Helixi106 – 114Combined sources9
Beta strandi119 – 124Combined sources6
Helixi125 – 127Combined sources3
Beta strandi130 – 132Combined sources3
Beta strandi137 – 141Combined sources5
Helixi143 – 145Combined sources3
Helixi146 – 156Combined sources11
Beta strandi159 – 162Combined sources4
Beta strandi173 – 179Combined sources7
Helixi185 – 193Combined sources9
Beta strandi198 – 204Combined sources7
Beta strandi210 – 216Combined sources7
Turni217 – 219Combined sources3
Beta strandi220 – 224Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KWMX-ray2.32A/B/C/D1-224[»]
4IO1X-ray1.65A/B1-224[»]
ProteinModelPortaliQ5NFM5.
SMRiQ5NFM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingCurated4
Regioni87 – 90Substrate bindingUniRule annotation4
Regioni100 – 103Substrate bindingCurated4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NFM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFNKKNNQD ELKKLAATEA AKSITTEITL GVGTGSTVGF LIEELVNYRD
60 70 80 90 100
KIKTVVSSSE DSTRKLKALG FDVVDLNYAG EIDLYIDGAD ECNNHKELIK
110 120 130 140 150
GGGAALTREK ICVAAAKKFI CIIDESKKVN TLGNFPLPIE VIPMARSYIA
160 170 180 190 200
RQIVKLGGQP VYREQTITDN GNVILDVYNL KIDNPLKLET ELNQITGVVT
210 220
NGIFALKPAD TVIMATKDSN IVVL
Length:224
Mass (Da):24,466
Last modified:February 1, 2005 - v1
Checksum:i46ACC58D7487CC2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45841.1.
RefSeqiWP_003015241.1. NZ_CP010290.1.
YP_170167.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45841; CAG45841; FTT_1208.
GeneIDi3192024.
KEGGiftu:FTT_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45841.1.
RefSeqiWP_003015241.1. NZ_CP010290.1.
YP_170167.1. NC_006570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KWMX-ray2.32A/B/C/D1-224[»]
4IO1X-ray1.65A/B1-224[»]
ProteinModelPortaliQ5NFM5.
SMRiQ5NFM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi177416.FTT_1208.

Protocols and materials databases

DNASUi3192024.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG45841; CAG45841; FTT_1208.
GeneIDi3192024.
KEGGiftu:FTT_1208.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276368.
KOiK01807.
OMAiGACHVQE.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_FRATT
AccessioniPrimary (citable) accession number: Q5NFM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.