SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5NFK5

- TYSY_FRATT

UniProt

Q5NFK5 - TYSY_FRATT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thymidylate synthase

Gene
thyA, FTT_1229
Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-1247-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:FTT_1229
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Thymidylate synthaseUniRule annotationPRO_0000140959Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ5NFK5. 1 interaction.
STRINGi177416.FTT_1229.

Structurei

3D structure databases

ProteinModelPortaliQ5NFK5.
SMRiQ5NFK5. Positions 2-274.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5NFK5-1 [UniParc]FASTAAdd to Basket

« Hide

MQEYLNFLKY IKENGVLKGD RTGTGTRSIF GYQMRFDLQK GFPLVTTKKI    50
HIPSVVHELL WFLSGSTNIK YLNDNNVRIW NEWATVDGEL GPIYGKQWRD 100
FNGQGIDQIA DVIQMLKTNP NSRRILVSAW NPCVVPSEKI SPQENVVKGN 150
SALPPCHAMF QFYVANNKLS CMLTQRSADA FLGVPFNIAS YSLLTNMVAQ 200
QCNLDVGEFI WSGGDCHIYN NHIEQVNEQL SREPLALPTL KILRKPNSIF 250
DYKYEDFEFE NYNHHPAIKA KISV 274
Length:274
Mass (Da):31,325
Last modified:February 1, 2005 - v1
Checksum:iA1AFE1C25D79A803
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45862.1.
RefSeqiYP_170187.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45862; CAG45862; FTT_1229.
GeneIDi3190786.
KEGGiftu:FTT_1229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45862.1 .
RefSeqi YP_170187.1. NC_006570.2.

3D structure databases

ProteinModelPortali Q5NFK5.
SMRi Q5NFK5. Positions 2-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5NFK5. 1 interaction.
STRINGi 177416.FTT_1229.

Protocols and materials databases

DNASUi 3190786.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG45862 ; CAG45862 ; FTT_1229 .
GeneIDi 3190786.
KEGGi ftu:FTT_1229.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci FTUL177416:GNBP-1247-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiTYSY_FRATT
AccessioniPrimary (citable) accession number: Q5NFK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi