Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5NFK5

- TYSY_FRATT

UniProt

Q5NFK5 - TYSY_FRATT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thymidylate synthase

Gene

thyA

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-1247-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:FTT_1229
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Thymidylate synthasePRO_0000140959Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ5NFK5. 1 interaction.
STRINGi177416.FTT_1229.

Structurei

3D structure databases

ProteinModelPortaliQ5NFK5.
SMRiQ5NFK5. Positions 2-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5NFK5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEYLNFLKY IKENGVLKGD RTGTGTRSIF GYQMRFDLQK GFPLVTTKKI
60 70 80 90 100
HIPSVVHELL WFLSGSTNIK YLNDNNVRIW NEWATVDGEL GPIYGKQWRD
110 120 130 140 150
FNGQGIDQIA DVIQMLKTNP NSRRILVSAW NPCVVPSEKI SPQENVVKGN
160 170 180 190 200
SALPPCHAMF QFYVANNKLS CMLTQRSADA FLGVPFNIAS YSLLTNMVAQ
210 220 230 240 250
QCNLDVGEFI WSGGDCHIYN NHIEQVNEQL SREPLALPTL KILRKPNSIF
260 270
DYKYEDFEFE NYNHHPAIKA KISV
Length:274
Mass (Da):31,325
Last modified:February 1, 2005 - v1
Checksum:iA1AFE1C25D79A803
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45862.1.
RefSeqiYP_170187.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45862; CAG45862; FTT_1229.
GeneIDi3190786.
KEGGiftu:FTT_1229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG45862.1 .
RefSeqi YP_170187.1. NC_006570.2.

3D structure databases

ProteinModelPortali Q5NFK5.
SMRi Q5NFK5. Positions 2-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5NFK5. 1 interaction.
STRINGi 177416.FTT_1229.

Protocols and materials databases

DNASUi 3190786.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG45862 ; CAG45862 ; FTT_1229 .
GeneIDi 3190786.
KEGGi ftu:FTT_1229.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci FTUL177416:GNBP-1247-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiTYSY_FRATT
AccessioniPrimary (citable) accession number: Q5NFK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3