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Q5NFC4

- G6PI_FRATT

UniProt

Q5NFC4 - G6PI_FRATT

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei346 – 3461Proton donorUniRule annotation
Active sitei377 – 3771UniRule annotation
Active sitei505 – 5051UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-1340-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:FTT_1315c
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Glucose-6-phosphate isomerasePRO_0000180644Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ5NFC4. 2 interactions.
STRINGi177416.FTT_1315c.

Structurei

Secondary structure

1
540
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Helixi6 – 127Combined sources
Helixi18 – 247Combined sources
Helixi28 – 314Combined sources
Beta strandi33 – 364Combined sources
Beta strandi39 – 424Combined sources
Helixi50 – 6213Combined sources
Helixi65 – 7410Combined sources
Turni80 – 834Combined sources
Helixi88 – 925Combined sources
Helixi106 – 12520Combined sources
Beta strandi139 – 1435Combined sources
Helixi146 – 1483Combined sources
Helixi150 – 1589Combined sources
Helixi160 – 1623Combined sources
Beta strandi168 – 1725Combined sources
Beta strandi174 – 1763Combined sources
Helixi177 – 1848Combined sources
Helixi189 – 1913Combined sources
Beta strandi192 – 1976Combined sources
Beta strandi199 – 2013Combined sources
Helixi204 – 22118Combined sources
Helixi224 – 2296Combined sources
Beta strandi231 – 2344Combined sources
Helixi238 – 2447Combined sources
Helixi248 – 2503Combined sources
Beta strandi251 – 2533Combined sources
Helixi260 – 2623Combined sources
Helixi267 – 2693Combined sources
Helixi270 – 2767Combined sources
Helixi278 – 29720Combined sources
Helixi300 – 3023Combined sources
Helixi304 – 31815Combined sources
Beta strandi323 – 3286Combined sources
Helixi331 – 3333Combined sources
Helixi336 – 34813Combined sources
Beta strandi366 – 3694Combined sources
Helixi374 – 3774Combined sources
Helixi380 – 3856Combined sources
Beta strandi392 – 3998Combined sources
Beta strandi401 – 4033Combined sources
Helixi405 – 42420Combined sources
Helixi428 – 43710Combined sources
Helixi442 – 45211Combined sources
Beta strandi460 – 4667Combined sources
Helixi470 – 49122Combined sources
Helixi499 – 5013Combined sources
Helixi502 – 51615Combined sources
Helixi521 – 5255Combined sources
Helixi528 – 53811Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LJKX-ray1.48A1-540[»]
3M5PX-ray1.65A1-540[»]
3Q7IX-ray1.54A1-540[»]
3Q88X-ray1.70A1-540[»]
ProteinModelPortaliQ5NFC4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5NFC4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiNCHFVAN.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NFC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFCDDSKKY LKEQNINLKN EFDKDDKRVE KFSLKHQNIY FDYSKNLIND
60 70 80 90 100
YILKSLLESA EKSSLKDKIK QMFNGAKINS TEHRAVLHTA LRDLSSTPLI
110 120 130 140 150
VDGQDIRQEV TKEKQRVKEL VEKVVSGRWR GFSGKKITDI VNIGIGGSDL
160 170 180 190 200
GPKMVVRALQ PYHCTDLKVH FVSNVDADSL LQALHVVDPE TTLFIIASKS
210 220 230 240 250
FSTEETLLNS ISAREWLLDH YEDEKAVANH FVAISSKLDK VKEFGIDLEH
260 270 280 290 300
CYKMWDWVGG RYSLWSSIGM SIAFAIGYDN FEKLLAGAYS VDKHFKETEF
310 320 330 340 350
SKNIPVIMAL LASYYSCTYN SQSQALLPYD ERLCYFVDYL QQADMESNGK
360 370 380 390 400
SVNIAGETVN YQTGVVLWGG VGTNGQHAFH QLLHQGNIFI PVDFIAIATS
410 420 430 440 450
HHNYDNHQQA LLANCFAQSQ ALMFGQSYDM VYNELLKSGL NETQAKELAA
460 470 480 490 500
HKVIPGNRPS TTILLDELSP YSLGALIALY EHKIFVQGVL WDINSYDQWG
510 520 530 540
VELGKKLGKN ILKAMNDDSS DEYQNLDDST RQLIAKVKNK
Length:540
Mass (Da):61,152
Last modified:February 1, 2005 - v1
Checksum:i4D34257EBD77D2FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45948.1.
RefSeqiYP_170268.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45948; CAG45948; FTT_1315c.
GeneIDi3191335.
KEGGiftu:FTT_1315c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45948.1 .
RefSeqi YP_170268.1. NC_006570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LJK X-ray 1.48 A 1-540 [» ]
3M5P X-ray 1.65 A 1-540 [» ]
3Q7I X-ray 1.54 A 1-540 [» ]
3Q88 X-ray 1.70 A 1-540 [» ]
ProteinModelPortali Q5NFC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5NFC4. 2 interactions.
STRINGi 177416.FTT_1315c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG45948 ; CAG45948 ; FTT_1315c .
GeneIDi 3191335.
KEGGi ftu:FTT_1315c.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261370.
KOi K01810.
OMAi NCHFVAN.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci FTUL177416:GNBP-1340-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5NFC4.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiG6PI_FRATT
AccessioniPrimary (citable) accession number: Q5NFC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3