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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei346Proton donorUniRule annotation1
Active sitei377UniRule annotation1
Active sitei505UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:FTT_1315c
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001174 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806441 – 540Glucose-6-phosphate isomeraseAdd BLAST540

Interactioni

Protein-protein interaction databases

IntActiQ5NFC4. 2 interactors.
STRINGi177416.FTT_1315c.

Structurei

Secondary structure

1540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi6 – 12Combined sources7
Helixi18 – 24Combined sources7
Helixi28 – 31Combined sources4
Beta strandi33 – 36Combined sources4
Beta strandi39 – 42Combined sources4
Helixi50 – 62Combined sources13
Helixi65 – 74Combined sources10
Turni80 – 83Combined sources4
Helixi88 – 92Combined sources5
Helixi106 – 125Combined sources20
Beta strandi139 – 143Combined sources5
Helixi146 – 148Combined sources3
Helixi150 – 158Combined sources9
Helixi160 – 162Combined sources3
Beta strandi168 – 172Combined sources5
Beta strandi174 – 176Combined sources3
Helixi177 – 184Combined sources8
Helixi189 – 191Combined sources3
Beta strandi192 – 197Combined sources6
Beta strandi199 – 201Combined sources3
Helixi204 – 221Combined sources18
Helixi224 – 229Combined sources6
Beta strandi231 – 234Combined sources4
Helixi238 – 244Combined sources7
Helixi248 – 250Combined sources3
Beta strandi251 – 253Combined sources3
Helixi260 – 262Combined sources3
Helixi267 – 269Combined sources3
Helixi270 – 276Combined sources7
Helixi278 – 297Combined sources20
Helixi300 – 302Combined sources3
Helixi304 – 318Combined sources15
Beta strandi323 – 328Combined sources6
Helixi331 – 333Combined sources3
Helixi336 – 348Combined sources13
Beta strandi366 – 369Combined sources4
Helixi374 – 377Combined sources4
Helixi380 – 385Combined sources6
Beta strandi392 – 399Combined sources8
Beta strandi401 – 403Combined sources3
Helixi405 – 424Combined sources20
Helixi428 – 437Combined sources10
Helixi442 – 452Combined sources11
Beta strandi460 – 466Combined sources7
Helixi470 – 491Combined sources22
Helixi499 – 501Combined sources3
Helixi502 – 516Combined sources15
Helixi521 – 525Combined sources5
Helixi528 – 538Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LJKX-ray1.48A1-540[»]
3M5PX-ray1.65A1-540[»]
3Q7IX-ray1.54A1-540[»]
3Q88X-ray1.70A1-540[»]
ProteinModelPortaliQ5NFC4.
SMRiQ5NFC4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5NFC4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiWLLEHSK.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NFC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFCDDSKKY LKEQNINLKN EFDKDDKRVE KFSLKHQNIY FDYSKNLIND
60 70 80 90 100
YILKSLLESA EKSSLKDKIK QMFNGAKINS TEHRAVLHTA LRDLSSTPLI
110 120 130 140 150
VDGQDIRQEV TKEKQRVKEL VEKVVSGRWR GFSGKKITDI VNIGIGGSDL
160 170 180 190 200
GPKMVVRALQ PYHCTDLKVH FVSNVDADSL LQALHVVDPE TTLFIIASKS
210 220 230 240 250
FSTEETLLNS ISAREWLLDH YEDEKAVANH FVAISSKLDK VKEFGIDLEH
260 270 280 290 300
CYKMWDWVGG RYSLWSSIGM SIAFAIGYDN FEKLLAGAYS VDKHFKETEF
310 320 330 340 350
SKNIPVIMAL LASYYSCTYN SQSQALLPYD ERLCYFVDYL QQADMESNGK
360 370 380 390 400
SVNIAGETVN YQTGVVLWGG VGTNGQHAFH QLLHQGNIFI PVDFIAIATS
410 420 430 440 450
HHNYDNHQQA LLANCFAQSQ ALMFGQSYDM VYNELLKSGL NETQAKELAA
460 470 480 490 500
HKVIPGNRPS TTILLDELSP YSLGALIALY EHKIFVQGVL WDINSYDQWG
510 520 530 540
VELGKKLGKN ILKAMNDDSS DEYQNLDDST RQLIAKVKNK
Length:540
Mass (Da):61,152
Last modified:February 1, 2005 - v1
Checksum:i4D34257EBD77D2FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45948.1.
RefSeqiWP_003022047.1. NZ_CP010290.1.
YP_170268.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG45948; CAG45948; FTT_1315c.
GeneIDi3191335.
KEGGiftu:FTT_1315c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG45948.1.
RefSeqiWP_003022047.1. NZ_CP010290.1.
YP_170268.1. NC_006570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LJKX-ray1.48A1-540[»]
3M5PX-ray1.65A1-540[»]
3Q7IX-ray1.54A1-540[»]
3Q88X-ray1.70A1-540[»]
ProteinModelPortaliQ5NFC4.
SMRiQ5NFC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5NFC4. 2 interactors.
STRINGi177416.FTT_1315c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG45948; CAG45948; FTT_1315c.
GeneIDi3191335.
KEGGiftu:FTT_1315c.

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiWLLEHSK.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Miscellaneous databases

EvolutionaryTraceiQ5NFC4.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_FRATT
AccessioniPrimary (citable) accession number: Q5NFC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.