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Q5NFC4

- G6PI_FRATT

UniProt

Q5NFC4 - G6PI_FRATT

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei346 – 3461Proton donorUniRule annotation
    Active sitei377 – 3771UniRule annotation
    Active sitei505 – 5051UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciFTUL177416:GNBP-1340-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:FTT_1315c
    OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
    Taxonomic identifieri177416 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001174: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Glucose-6-phosphate isomerasePRO_0000180644Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ5NFC4. 2 interactions.
    STRINGi177416.FTT_1315c.

    Structurei

    Secondary structure

    1
    540
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 53
    Helixi6 – 127
    Helixi18 – 247
    Helixi28 – 314
    Beta strandi33 – 364
    Beta strandi39 – 424
    Helixi50 – 6213
    Helixi65 – 7410
    Turni80 – 834
    Helixi88 – 925
    Helixi106 – 12520
    Beta strandi139 – 1435
    Helixi146 – 1483
    Helixi150 – 1589
    Helixi160 – 1623
    Beta strandi168 – 1725
    Beta strandi174 – 1763
    Helixi177 – 1848
    Helixi189 – 1913
    Beta strandi192 – 1976
    Beta strandi199 – 2013
    Helixi204 – 22118
    Helixi224 – 2296
    Beta strandi231 – 2344
    Helixi238 – 2447
    Helixi248 – 2503
    Beta strandi251 – 2533
    Helixi260 – 2623
    Helixi267 – 2693
    Helixi270 – 2767
    Helixi278 – 29720
    Helixi300 – 3023
    Helixi304 – 31815
    Beta strandi323 – 3286
    Helixi331 – 3333
    Helixi336 – 34813
    Beta strandi366 – 3694
    Helixi374 – 3774
    Helixi380 – 3856
    Beta strandi392 – 3998
    Beta strandi401 – 4033
    Helixi405 – 42420
    Helixi428 – 43710
    Helixi442 – 45211
    Beta strandi460 – 4667
    Helixi470 – 49122
    Helixi499 – 5013
    Helixi502 – 51615
    Helixi521 – 5255
    Helixi528 – 53811

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LJKX-ray1.48A1-540[»]
    3M5PX-ray1.65A1-540[»]
    3Q7IX-ray1.54A1-540[»]
    3Q88X-ray1.70A1-540[»]
    ProteinModelPortaliQ5NFC4.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5NFC4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261370.
    KOiK01810.
    OMAiNCHFVAN.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NFC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFCDDSKKY LKEQNINLKN EFDKDDKRVE KFSLKHQNIY FDYSKNLIND    50
    YILKSLLESA EKSSLKDKIK QMFNGAKINS TEHRAVLHTA LRDLSSTPLI 100
    VDGQDIRQEV TKEKQRVKEL VEKVVSGRWR GFSGKKITDI VNIGIGGSDL 150
    GPKMVVRALQ PYHCTDLKVH FVSNVDADSL LQALHVVDPE TTLFIIASKS 200
    FSTEETLLNS ISAREWLLDH YEDEKAVANH FVAISSKLDK VKEFGIDLEH 250
    CYKMWDWVGG RYSLWSSIGM SIAFAIGYDN FEKLLAGAYS VDKHFKETEF 300
    SKNIPVIMAL LASYYSCTYN SQSQALLPYD ERLCYFVDYL QQADMESNGK 350
    SVNIAGETVN YQTGVVLWGG VGTNGQHAFH QLLHQGNIFI PVDFIAIATS 400
    HHNYDNHQQA LLANCFAQSQ ALMFGQSYDM VYNELLKSGL NETQAKELAA 450
    HKVIPGNRPS TTILLDELSP YSLGALIALY EHKIFVQGVL WDINSYDQWG 500
    VELGKKLGKN ILKAMNDDSS DEYQNLDDST RQLIAKVKNK 540
    Length:540
    Mass (Da):61,152
    Last modified:February 1, 2005 - v1
    Checksum:i4D34257EBD77D2FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG45948.1.
    RefSeqiYP_170268.1. NC_006570.2.

    Genome annotation databases

    EnsemblBacteriaiCAG45948; CAG45948; FTT_1315c.
    GeneIDi3191335.
    KEGGiftu:FTT_1315c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG45948.1 .
    RefSeqi YP_170268.1. NC_006570.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LJK X-ray 1.48 A 1-540 [» ]
    3M5P X-ray 1.65 A 1-540 [» ]
    3Q7I X-ray 1.54 A 1-540 [» ]
    3Q88 X-ray 1.70 A 1-540 [» ]
    ProteinModelPortali Q5NFC4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5NFC4. 2 interactions.
    STRINGi 177416.FTT_1315c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG45948 ; CAG45948 ; FTT_1315c .
    GeneIDi 3191335.
    KEGGi ftu:FTT_1315c.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261370.
    KOi K01810.
    OMAi NCHFVAN.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci FTUL177416:GNBP-1340-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5NFC4.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCHU S4 / Schu 4.

    Entry informationi

    Entry nameiG6PI_FRATT
    AccessioniPrimary (citable) accession number: Q5NFC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3