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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateUniRule annotation
Binding sitei113 – 1131SubstrateUniRule annotation
Binding sitei146 – 1461SubstrateUniRule annotation
Binding sitei197 – 1971ATPUniRule annotation
Binding sitei319 – 3191ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi345 – 3484ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-1398-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:FTT_1367c
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Phosphoglycerate kinasePRO_1000057994Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi177416.FTT_1367c.

Structurei

Secondary structure

1
392
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83Combined sources
Beta strandi15 – 195Combined sources
Beta strandi30 – 323Combined sources
Helixi35 – 395Combined sources
Helixi41 – 5010Combined sources
Beta strandi53 – 575Combined sources
Helixi70 – 723Combined sources
Helixi75 – 8511Combined sources
Beta strandi89 – 946Combined sources
Turni95 – 973Combined sources
Beta strandi106 – 1094Combined sources
Helixi112 – 1143Combined sources
Turni116 – 1216Combined sources
Helixi123 – 1319Combined sources
Beta strandi134 – 1385Combined sources
Helixi141 – 1433Combined sources
Turni149 – 1524Combined sources
Helixi153 – 1575Combined sources
Beta strandi158 – 1636Combined sources
Helixi165 – 17814Combined sources
Beta strandi183 – 19210Combined sources
Helixi194 – 20411Combined sources
Turni205 – 2073Combined sources
Beta strandi209 – 2157Combined sources
Helixi216 – 2249Combined sources
Helixi236 – 2383Combined sources
Helixi239 – 25113Combined sources
Beta strandi260 – 26910Combined sources
Beta strandi275 – 2784Combined sources
Helixi279 – 2813Combined sources
Beta strandi287 – 2915Combined sources
Helixi293 – 30513Combined sources
Beta strandi307 – 3126Combined sources
Helixi321 – 3233Combined sources
Helixi325 – 33713Combined sources
Beta strandi339 – 3457Combined sources
Helixi346 – 3549Combined sources
Helixi358 – 3603Combined sources
Beta strandi361 – 3655Combined sources
Helixi369 – 3757Combined sources
Helixi381 – 3888Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EHJX-ray2.71A/B1-392[»]
4FEYX-ray2.30A1-392[»]
ProteinModelPortaliQ5NF76.
SMRiQ5NF76. Positions 2-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingUniRule annotation
Regioni59 – 624Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NF76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLTLKDVD LKDKKVLVRV DFNVPVKDGK VTSKVRIEAA IPTIQYILDQ
60 70 80 90 100
GGAVILMSHL GRPTEGEYDS QFSLEPVAKA LSEIINKPVK FAKDWLDGVD
110 120 130 140 150
VKAGEIVMCE NVRFNSGEKK STDDLSKKIA SLGDVFVMDA FATAHRAQAS
160 170 180 190 200
TYGVAKYIPV ACAGILLTNE IQALEKALKS PKKPMAAIVG GSKVSTKLSV
210 220 230 240 250
LNNLLDKVEI LIVGGGIANT FIKAEGFDVG NSLYEQDLVA EATEILAKAK
260 270 280 290 300
ALGVNIPVPV DVRVAKEFSE NAQAIIKKVS DVVADEMILD IGPESQKIIA
310 320 330 340 350
ELLKSANTIL WNGPVGVFEF DNFAEGTKAL SLAIAQSHAF SVAGGGDTIA
360 370 380 390
AIEKFGIKDQ VSYISTAGGA FLEFLEGKKL PAIEILKEKA IR
Length:392
Mass (Da):41,937
Last modified:February 1, 2005 - v1
Checksum:i15AEE0E9ED62DFD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG46000.1.
RefSeqiYP_170316.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG46000; CAG46000; FTT_1367c.
GeneIDi3191360.
KEGGiftu:FTT_1367c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG46000.1.
RefSeqiYP_170316.1. NC_006570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EHJX-ray2.71A/B1-392[»]
4FEYX-ray2.30A1-392[»]
ProteinModelPortaliQ5NF76.
SMRiQ5NF76. Positions 2-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi177416.FTT_1367c.

Protocols and materials databases

DNASUi3191360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG46000; CAG46000; FTT_1367c.
GeneIDi3191360.
KEGGiftu:FTT_1367c.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciFTUL177416:GNBP-1398-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiPGK_FRATT
AccessioniPrimary (citable) accession number: Q5NF76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 1, 2005
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.