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Protein

Acyl carrier protein

Gene

acpP

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-1407-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier proteinUniRule annotation
Gene namesi
Name:acpPUniRule annotationImported
Ordered Locus Names:FTT_1376Imported
ORF Names:BZ14_1407Imported
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)Imported
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521O-(pantetheine 4'-phosphoryl)serineUniRule annotation

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.UniRule annotation
4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.UniRule annotation

Keywords - PTMi

PhosphopantetheineUniRule annotation, PhosphoproteinUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

IntActiQ5NF67. 5 interactions.
STRINGi177416.FTT_1376.

Structurei

3D structure databases

ProteinModelPortaliQ5NF67.
SMRiQ5NF67. Positions 22-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000178184.
KOiK02078.
OMAiNFKTVGD.
OrthoDBiEOG6MWNJM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier.
InterProiIPR003231. Acyl_carrier.
IPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NF67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTHNEDSKK NNADEKAKIF SRVNHIIVEQ LGVKEEDLKP EASFIDDLGA
60 70 80 90
DSLDTVELVM ALEEEFDTEI PDEDAEKIRT VKDVYDYIES KDVG
Length:94
Mass (Da):10,660
Last modified:February 1, 2005 - v1
Checksum:i9392F7F4A5EBC07F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP010290 Genomic DNA. Translation: AJI69795.1.
AJ749949 Genomic DNA. Translation: CAG46009.1.
RefSeqiYP_170325.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG46009; CAG46009; FTT_1376.
GeneIDi3192405.
KEGGiftu:FTT_1376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP010290 Genomic DNA. Translation: AJI69795.1.
AJ749949 Genomic DNA. Translation: CAG46009.1.
RefSeqiYP_170325.1. NC_006570.2.

3D structure databases

ProteinModelPortaliQ5NF67.
SMRiQ5NF67. Positions 22-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5NF67. 5 interactions.
STRINGi177416.FTT_1376.

Protocols and materials databases

DNASUi3192405.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG46009; CAG46009; FTT_1376.
GeneIDi3192405.
KEGGiftu:FTT_1376.

Phylogenomic databases

HOGENOMiHOG000178184.
KOiK02078.
OMAiNFKTVGD.
OrthoDBiEOG6MWNJM.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciFTUL177416:GNBP-1407-MONOMER.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier.
InterProiIPR003231. Acyl_carrier.
IPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4Imported and SCHU S4 / Schu 4Imported.
  2. Duffield M.L.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SCHU S4Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SHU-S4Imported.

Entry informationi

Entry nameiQ5NF67_FRATT
AccessioniPrimary (citable) accession number: Q5NF67
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.