Q5NF67 (Q5NF67_FRATT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl carrier protein HAMAP-Rule MF_01217
Short name=ACP HAMAP-Rule MF_01217

Gene names

Name:	acpP HAMAP-Rule MF_01217
Ordered Locus Names:	FTT_1376

Organism

Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [Reference proteome] [HAMAP] EMBL CAG46009.1

Taxonomic identifier

177416 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella tularensis subsp. tularensis

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis By similarity. HAMAP-Rule MF_01217 RuleBase RU003545
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP-Rule MF_01217 RuleBase RU003545 SAAS SAAS006162
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01217.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group By similarity. HAMAP-Rule MF_01217 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS By similarity. RuleBase RU003545
Sequence similarities	Contains 1 acyl carrier domain. HAMAP-Rule MF_01217 RuleBase RU003545 SAAS SAAS006162

Ontologies

Keywords
Biological process	Fatty acid biosynthesis HAMAP-Rule MF_01217 SAAS SAAS006162 Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm HAMAP-Rule MF_01217
Ligand	Phosphopantetheine HAMAP-Rule MF_01217 RuleBase RU000721
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	52	1	O-(pantetheine 4'-phosphoryl)serine By similarity HAMAP-Rule MF_01217

Sequences

	Sequence		Length	Mass (Da)
	Q5NF67 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 9392F7F4A5EBC07F	FASTA	94	10,660
	10 20 30 40 50 60 MSTHNEDSKK NNADEKAKIF SRVNHIIVEQ LGVKEEDLKP EASFIDDLGA DSLDTVELVM 70 80 90 ALEEEFDTEI PDEDAEKIRT VKDVYDYIES KDVG

References

[1]

"The complete genome sequence of Francisella tularensis, the causative agent of tularemia." Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H., Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D., Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S., Sjoestedt A. , Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W., Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W. Nat. Genet. 37:153-159(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCHU S4 / Schu 4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ749949 Genomic DNA. Translation: CAG46009.1.
RefSeq	YP_170325.1. NC_006570.2.
3D structure databases
ProteinModelPortal	Q5NF67.
SMR	Q5NF67. Positions 22-91.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5NF67. 5 interactions.
STRING	177416.FTT_1376.
Protocols and materials databases
DNASU	3192405.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG46009; CAG46009; FTT_1376.
GeneID	3192405.
KEGG	ftu:FTT_1376.
Phylogenomic databases
HOGENOM	HOG000178184.
KO	K02078.
OMA	ANFANDL.
ProtClustDB	PRK00982.
Enzyme and pathway databases
UniPathway	UPA00094.
Family and domain databases
Gene3D	1.10.1200.10. 1 hit.
HAMAP	MF_01217. Acyl_carrier.
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006162. PPantetheine_attach_site. [Graphical view]
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
ProDom	PD000887. PD000887. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR00517. acyl_carrier. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5NF67_FRATT

Accession

Primary (citable) accession number: Q5NF67

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)