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Q5NF57

- PANC_FRATT

UniProt

Q5NF57 - PANC_FRATT

Protein

Pantothenate synthetase

Gene

panC

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361Proton donorUniRule annotation
    Binding sitei60 – 601Beta-alanineUniRule annotation
    Binding sitei60 – 601PantoateUniRule annotation
    Binding sitei153 – 1531PantoateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 368ATPUniRule annotation
    Nucleotide bindingi147 – 1504ATPUniRule annotation
    Nucleotide bindingi184 – 1874ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFTUL177416:GNBP-1421-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:FTT_1390
    OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
    Taxonomic identifieri177416 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001174: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Pantothenate synthetasePRO_0000305450Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi177416.FTT_1390.

    Structurei

    Secondary structure

    1
    261
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 43
    Helixi7 – 159
    Beta strandi23 – 286
    Helixi34 – 4613
    Beta strandi48 – 547
    Helixi58 – 603
    Helixi64 – 696
    Helixi74 – 8310
    Beta strandi87 – 904
    Helixi94 – 974
    Beta strandi104 – 1085
    Helixi111 – 1144
    Helixi117 – 1204
    Helixi124 – 13916
    Beta strandi142 – 1476
    Helixi151 – 16313
    Beta strandi169 – 1735
    Helixi186 – 1905
    Helixi193 – 20715
    Helixi214 – 2229
    Turni223 – 2253
    Beta strandi227 – 2348
    Beta strandi237 – 2448
    Beta strandi247 – 2548
    Turni255 – 2573

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3N8HX-ray2.00A/B1-261[»]
    3QTTX-ray2.60A/B1-258[»]
    ProteinModelPortaliQ5NF57.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5NF57.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175517.
    KOiK01918.
    OMAiAYMGSTR.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5NF57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIADNIKQF HSIRNSLIKQ QKIGFVPTMG ALHNGHISLI KKAKSENDVV    50
    IVSIFVNPTQ FNNPNDYQTY PNQLQQDIQI LASLDVDVLF NPSEKDIYPD 100
    GNLLRIEPKL EIANILEGKS RPGHFSGMLT VVLKLLQITK PNNLYLGEKD 150
    YQQVMLIKQL VKDFFINTKI IVCPTQRQPS GLPLSSRNKN LTSTDIEIAN 200
    KIYEILRQDD FSNLEELTNK INSTGAKLQY IQKLNNRIFL AFYIGKVRLI 250
    DNFLKETGPS C 261
    Length:261
    Mass (Da):29,715
    Last modified:February 1, 2005 - v1
    Checksum:i9EF115B43EDC2FDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG46023.1.
    RefSeqiYP_170335.1. NC_006570.2.

    Genome annotation databases

    EnsemblBacteriaiCAG46023; CAG46023; FTT_1390.
    GeneIDi3191378.
    KEGGiftu:FTT_1390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ749949 Genomic DNA. Translation: CAG46023.1 .
    RefSeqi YP_170335.1. NC_006570.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3N8H X-ray 2.00 A/B 1-261 [» ]
    3QTT X-ray 2.60 A/B 1-258 [» ]
    ProteinModelPortali Q5NF57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177416.FTT_1390.

    Protocols and materials databases

    DNASUi 3191378.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG46023 ; CAG46023 ; FTT_1390 .
    GeneIDi 3191378.
    KEGGi ftu:FTT_1390.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175517.
    KOi K01918.
    OMAi AYMGSTR.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci FTUL177416:GNBP-1421-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5NF57.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCHU S4 / Schu 4.

    Entry informationi

    Entry nameiPANC_FRATT
    AccessioniPrimary (citable) accession number: Q5NF57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3