Q5NET6 (Q5NET6_FRATT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase EMBL CAG46159.1
EC=1.1.1.42 EMBL CAG46159.1

Gene names

Name:	idh EMBL CAG46159.1
Ordered Locus Names:	FTT_1526c

Organism

Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [Reference proteome] [HAMAP] EMBL CAG46159.1

Taxonomic identifier

177416 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella tularensis subsp. tularensis

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL CAG46159.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	139 – 146	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	357	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	555	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	559	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	152	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	554	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	262	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	427	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	Q5NET6 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 0DA5A2486A37EEFD	FASTA	747	83,454
	10 20 30 40 50 60 MKFYLQEIFM HKIFYTFTDE APALATGSFL PIVESFTKVA DIELETKDIS LSARILANFN 70 80 90 100 110 120 DYLTAEQKCS DDLAILGELA KTPDANIIKL PNISASIPQL TAAIKELQSK GYKIPDYPYE 130 140 150 160 170 180 PKDDKEQEIK ARYAKVLGSA VNPVLREGNS DRRVADAVKK YAEKHPHSMG EWTKDSKSHV 190 200 210 220 230 240 ASMSADDFYA NEKSYIVPKA TKVKIVHIDT KGTQTVLKDN LALEEKEIID ATKISIKALR 250 260 270 280 290 300 EFYKNEIAKA KKEGTLLSLH LKATMMKVSD PILFGHAVEI FFEDIFKKYA KEFKELGVNP 310 320 330 340 350 360 RNGWGDAVEK IKQLPQELQD KINADIEKVF AKQPDIAMVN SNKGITNLNV PSDVIIDASM 370 380 390 400 410 420 PAAIRSSGKM WNKDGKLQDM KAMIPDRCYA GVYAATIDFC KENGAFDVAT MGDVSNVGLM 430 440 450 460 470 480 AKKAEEYGSH DKTFEIQADG KVEVIDAEGN VIFEHQVEKG DIWRACQTKD IAVKDWVKLV 490 500 510 520 530 540 VNRAKITQNP AIFWLDSKRA HDRNLIAKVN EYLTHHDTTG LDIQILSPVE ATKYSLKRMK 550 560 570 580 590 600 EGKNTISVTG NVLRDYLTDL FPILELGTSA KMLSIVPLLA GGGLFETGAG GSAPKHVEQL 610 620 630 640 650 660 IEENHLRWDS LGEFLALGAS LEDLAIKTRD AKIKVLAETL SQANKDFLDN DKSPRRKVGE 670 680 690 700 710 720 LDTRGSHFYL AYYWVKALAE QTGNAELKAK FEPIYIELKA NKDKIVKELN DAQGKKVDVG 730 740 GYYHMDRVKL DAVMRPSKTF NTILAQI

References

[1]

"The complete genome sequence of Francisella tularensis, the causative agent of tularemia." Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H., Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D., Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S., Sjoestedt A. , Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W., Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W. Nat. Genet. 37:153-159(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCHU S4 / Schu 4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ749949 Genomic DNA. Translation: CAG46159.1.
RefSeq	YP_170456.1. NC_006570.2.
3D structure databases
ProteinModelPortal	Q5NET6.
SMR	Q5NET6. Positions 12-747.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5NET6. 2 interactions.
STRING	177416.FTT_1526c.
Protocols and materials databases
DNASU	3192248.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG46159; CAG46159; FTT_1526c.
GeneID	3192248.
KEGG	ftu:FTT_1526c.
Phylogenomic databases
HOGENOM	HOG000240860.
KO	K00031.
OMA	FRMCQTK.
ProtClustDB	CLSK867411.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5NET6_FRATT

Accession

Primary (citable) accession number: Q5NET6

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)