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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

idh

Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei152SubstrateUniRule annotation1
Sitei262Critical for catalysisUniRule annotation1
Metal bindingi357Magnesium or manganeseUniRule annotation1
Sitei427Critical for catalysisUniRule annotation1
Binding sitei554SubstrateUniRule annotation1
Metal bindingi555Magnesium or manganeseUniRule annotation1
Metal bindingi559Magnesium or manganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:idhImported
Ordered Locus Names:FTT_1526cImported
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)Imported
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001174 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

IntActiQ5NET6. 2 interactors.
STRINGi177416.FTT_1526c.

Structurei

3D structure databases

ProteinModelPortaliQ5NET6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 146Substrate bindingUniRule annotation8

Phylogenomic databases

eggNOGiENOG4105E9K. Bacteria.
COG2838. LUCA.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NET6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFYLQEIFM HKIFYTFTDE APALATGSFL PIVESFTKVA DIELETKDIS
60 70 80 90 100
LSARILANFN DYLTAEQKCS DDLAILGELA KTPDANIIKL PNISASIPQL
110 120 130 140 150
TAAIKELQSK GYKIPDYPYE PKDDKEQEIK ARYAKVLGSA VNPVLREGNS
160 170 180 190 200
DRRVADAVKK YAEKHPHSMG EWTKDSKSHV ASMSADDFYA NEKSYIVPKA
210 220 230 240 250
TKVKIVHIDT KGTQTVLKDN LALEEKEIID ATKISIKALR EFYKNEIAKA
260 270 280 290 300
KKEGTLLSLH LKATMMKVSD PILFGHAVEI FFEDIFKKYA KEFKELGVNP
310 320 330 340 350
RNGWGDAVEK IKQLPQELQD KINADIEKVF AKQPDIAMVN SNKGITNLNV
360 370 380 390 400
PSDVIIDASM PAAIRSSGKM WNKDGKLQDM KAMIPDRCYA GVYAATIDFC
410 420 430 440 450
KENGAFDVAT MGDVSNVGLM AKKAEEYGSH DKTFEIQADG KVEVIDAEGN
460 470 480 490 500
VIFEHQVEKG DIWRACQTKD IAVKDWVKLV VNRAKITQNP AIFWLDSKRA
510 520 530 540 550
HDRNLIAKVN EYLTHHDTTG LDIQILSPVE ATKYSLKRMK EGKNTISVTG
560 570 580 590 600
NVLRDYLTDL FPILELGTSA KMLSIVPLLA GGGLFETGAG GSAPKHVEQL
610 620 630 640 650
IEENHLRWDS LGEFLALGAS LEDLAIKTRD AKIKVLAETL SQANKDFLDN
660 670 680 690 700
DKSPRRKVGE LDTRGSHFYL AYYWVKALAE QTGNAELKAK FEPIYIELKA
710 720 730 740
NKDKIVKELN DAQGKKVDVG GYYHMDRVKL DAVMRPSKTF NTILAQI
Length:747
Mass (Da):83,454
Last modified:February 1, 2005 - v1
Checksum:i0DA5A2486A37EEFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG46159.1.
RefSeqiWP_003022408.1. NC_006570.2.
YP_170456.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG46159; CAG46159; FTT_1526c.
GeneIDi3192248.
KEGGiftu:FTT_1526c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749949 Genomic DNA. Translation: CAG46159.1.
RefSeqiWP_003022408.1. NC_006570.2.
YP_170456.1. NC_006570.2.

3D structure databases

ProteinModelPortaliQ5NET6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5NET6. 2 interactors.
STRINGi177416.FTT_1526c.

Protocols and materials databases

DNASUi3192248.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG46159; CAG46159; FTT_1526c.
GeneIDi3192248.
KEGGiftu:FTT_1526c.

Phylogenomic databases

eggNOGiENOG4105E9K. Bacteria.
COG2838. LUCA.
HOGENOMiHOG000240860.
KOiK00031.
OMAiRDSGKMW.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5NET6_FRATT
AccessioniPrimary (citable) accession number: Q5NET6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.