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Q5NET6

- Q5NET6_FRATT

UniProt

Q5NET6 - Q5NET6_FRATT

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene
idh, FTT_1526c
Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521Substrate By similarityUniRule annotation
Sitei262 – 2621Critical for catalysis By similarity
Metal bindingi357 – 3571Magnesium or manganese By similarityUniRule annotation
Sitei427 – 4271Critical for catalysis By similarityUniRule annotation
Binding sitei554 – 5541Substrate By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium or manganese By similarityUniRule annotation
Metal bindingi559 – 5591Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFTUL177416:GNBP-1564-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:idhImported
Ordered Locus Names:FTT_1526cImported
OrganismiFrancisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)Imported
Taxonomic identifieri177416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001174: Chromosome

Interactioni

Protein-protein interaction databases

IntActiQ5NET6. 2 interactions.
STRINGi177416.FTT_1526c.

Structurei

3D structure databases

ProteinModelPortaliQ5NET6.
SMRiQ5NET6. Positions 12-747.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1468Substrate binding By similarityUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5NET6-1 [UniParc]FASTAAdd to Basket

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MKFYLQEIFM HKIFYTFTDE APALATGSFL PIVESFTKVA DIELETKDIS    50
LSARILANFN DYLTAEQKCS DDLAILGELA KTPDANIIKL PNISASIPQL 100
TAAIKELQSK GYKIPDYPYE PKDDKEQEIK ARYAKVLGSA VNPVLREGNS 150
DRRVADAVKK YAEKHPHSMG EWTKDSKSHV ASMSADDFYA NEKSYIVPKA 200
TKVKIVHIDT KGTQTVLKDN LALEEKEIID ATKISIKALR EFYKNEIAKA 250
KKEGTLLSLH LKATMMKVSD PILFGHAVEI FFEDIFKKYA KEFKELGVNP 300
RNGWGDAVEK IKQLPQELQD KINADIEKVF AKQPDIAMVN SNKGITNLNV 350
PSDVIIDASM PAAIRSSGKM WNKDGKLQDM KAMIPDRCYA GVYAATIDFC 400
KENGAFDVAT MGDVSNVGLM AKKAEEYGSH DKTFEIQADG KVEVIDAEGN 450
VIFEHQVEKG DIWRACQTKD IAVKDWVKLV VNRAKITQNP AIFWLDSKRA 500
HDRNLIAKVN EYLTHHDTTG LDIQILSPVE ATKYSLKRMK EGKNTISVTG 550
NVLRDYLTDL FPILELGTSA KMLSIVPLLA GGGLFETGAG GSAPKHVEQL 600
IEENHLRWDS LGEFLALGAS LEDLAIKTRD AKIKVLAETL SQANKDFLDN 650
DKSPRRKVGE LDTRGSHFYL AYYWVKALAE QTGNAELKAK FEPIYIELKA 700
NKDKIVKELN DAQGKKVDVG GYYHMDRVKL DAVMRPSKTF NTILAQI 747
Length:747
Mass (Da):83,454
Last modified:February 1, 2005 - v1
Checksum:i0DA5A2486A37EEFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG46159.1.
RefSeqiYP_170456.1. NC_006570.2.

Genome annotation databases

EnsemblBacteriaiCAG46159; CAG46159; FTT_1526c.
GeneIDi3192248.
KEGGiftu:FTT_1526c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ749949 Genomic DNA. Translation: CAG46159.1 .
RefSeqi YP_170456.1. NC_006570.2.

3D structure databases

ProteinModelPortali Q5NET6.
SMRi Q5NET6. Positions 12-747.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5NET6. 2 interactions.
STRINGi 177416.FTT_1526c.

Protocols and materials databases

DNASUi 3192248.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG46159 ; CAG46159 ; FTT_1526c .
GeneIDi 3192248.
KEGGi ftu:FTT_1526c.

Phylogenomic databases

HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci FTUL177416:GNBP-1564-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCHU S4 / Schu 4.

Entry informationi

Entry nameiQ5NET6_FRATT
AccessioniPrimary (citable) accession number: Q5NET6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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