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Q5NE14

- Q5NE14_DANRE

UniProt

Q5NE14 - Q5NE14_DANRE

Protein
Submitted name:

Protein kinase containing Z-DNA binding domains

Gene

pkz

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. double-stranded RNA adenosine deaminase activity Source: InterPro
    3. protein serine/threonine kinase activity Source: UniProtKB-KW
    4. RNA binding Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein kinase containing Z-DNA binding domainsImported
    Submitted name:
    Uncharacterized proteinImported
    Submitted name:
    Z-DNA binding protein kinaseImported
    Gene namesi
    Name:pkzImported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 13

    Organism-specific databases

    ZFINiZDB-GENE-050301-2. pkz.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LB5X-ray2.00A/B5-70[»]
    4LB6X-ray1.80B5-70[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni36 – 394Acetate 2 bindingImported
    Regioni61 – 622Acetate 3 bindingImported

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000062984.
    HOVERGENiHBG055855.
    InParanoidiQ5NE14.
    KOiK16195.
    OMAiNEIEMRI.
    OrthoDBiEOG71VSSK.
    TreeFamiTF317576.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR000607. dsRNA_A_deaminase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 2 hits.
    PF02295. z-alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5NE14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKMSAENEI EMRICDYLRR HGRSTVQDIF KELKLEKSTV NRHLYSLQAS    50
    KQVFKTVEDN KRPVWNLVES MNDEQKAKPE QIKPEMTRDA IEEKHVKDLL 100
    KSGGLKASHI ASKLGQQTQS TNKLLYGLME KGEVRKCSKS HMWTLKNDQE 150
    RNGSGSDRKL TSVSGMSQTF DVIEELGDGG YGFVCKVKHK IDDKIYAVKR 200
    VEFNSEAEPE VKALARLDHP NIVRYFTCWP DSDNWMSNQE TNEKSNTTGS 250
    STDTDDTNER SASDDDVADD EDDDDDDVSD DVTLGMESLT FTESTSAAKA 300
    SGQCDPTNHR TYLFIQMEFC EGGTLTSWIG ERNYGGKQRI PLEIHRIFYE 350
    ISSGVEYIHS NNLIHRDLKP DNILFNDGKV KIGDFGLVAA QKNPSGDPIE 400
    RSKRKGTPTY MSPEQENLRN YDEKTDIFPL GLMWFEMLWK ISSGMERAEI 450
    WTNLRNQKLP DQFCERYTAE NKFIEKMLSV TPEDRPHAKD IRLNLETFFS 500
    LHQNSLSQKT I 511
    Length:511
    Mass (Da):58,539
    Last modified:February 1, 2005 - v1
    Checksum:i1E7E7695B63B9EEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU929278 Genomic DNA. No translation available.
    BC115215 mRNA. Translation: AAI15216.1.
    BC131857 mRNA. Translation: AAI31858.1.
    BC162488 mRNA. Translation: AAI62488.1.
    AJ852019 mRNA. Translation: CAH68526.1.
    RefSeqiNP_001035466.1. NM_001040376.2.
    UniGeneiDr.18486.

    Genome annotation databases

    EnsembliENSDART00000038391; ENSDARP00000033668; ENSDARG00000052396.
    GeneIDi503703.
    KEGGidre:503703.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU929278 Genomic DNA. No translation available.
    BC115215 mRNA. Translation: AAI15216.1 .
    BC131857 mRNA. Translation: AAI31858.1 .
    BC162488 mRNA. Translation: AAI62488.1 .
    AJ852019 mRNA. Translation: CAH68526.1 .
    RefSeqi NP_001035466.1. NM_001040376.2.
    UniGenei Dr.18486.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LB5 X-ray 2.00 A/B 5-70 [» ]
    4LB6 X-ray 1.80 B 5-70 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000038391 ; ENSDARP00000033668 ; ENSDARG00000052396 .
    GeneIDi 503703.
    KEGGi dre:503703.

    Organism-specific databases

    CTDi 503703.
    ZFINi ZDB-GENE-050301-2. pkz.

    Phylogenomic databases

    GeneTreei ENSGT00530000062984.
    HOVERGENi HBG055855.
    InParanoidi Q5NE14.
    KOi K16195.
    OMAi NEIEMRI.
    OrthoDBi EOG71VSSK.
    TreeFami TF317576.

    Miscellaneous databases

    NextBioi 20866259.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR000607. dsRNA_A_deaminase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 2 hits.
    PF02295. z-alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains."
      Rothenburg S., Deigendesch N., Dittmar K., Koch-Nolte F., Haag F., Lowenhaupt K., Rich A.
      Proc. Natl. Acad. Sci. U.S.A. 102:1602-1607(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: WholeImported.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    4. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    6. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.
    7. "Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ."
      de Rosa M., Zacarias S., Athanasiadis A.
      Nucleic Acids Res. 41:9924-9933(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 5-70.

    Entry informationi

    Entry nameiQ5NE14_DANRE
    AccessioniPrimary (citable) accession number: Q5NE14
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3