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Q5NE14

- Q5NE14_DANRE

UniProt

Q5NE14 - Q5NE14_DANRE

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Protein
Submitted name:

Protein kinase containing Z-DNA binding domains

Gene

pkz

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. double-stranded RNA adenosine deaminase activity Source: InterPro
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
  4. RNA binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase containing Z-DNA binding domainsImported
Submitted name:
Uncharacterized proteinImported
Submitted name:
Z-DNA binding protein kinaseImported
Gene namesi
Name:pkzImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-050301-2. pkz.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LB5X-ray2.00A/B5-70[»]
4LB6X-ray1.80B5-70[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni36 – 394Acetate 2 bindingImported
Regioni61 – 622Acetate 3 bindingImported

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000062984.
HOVERGENiHBG055855.
KOiK16195.
OMAiNEIEMRI.
OrthoDBiEOG71VSSK.
TreeFamiTF317576.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR000607. dsRNA_A_deaminase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF02295. z-alpha. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NE14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKMSAENEI EMRICDYLRR HGRSTVQDIF KELKLEKSTV NRHLYSLQAS
60 70 80 90 100
KQVFKTVEDN KRPVWNLVES MNDEQKAKPE QIKPEMTRDA IEEKHVKDLL
110 120 130 140 150
KSGGLKASHI ASKLGQQTQS TNKLLYGLME KGEVRKCSKS HMWTLKNDQE
160 170 180 190 200
RNGSGSDRKL TSVSGMSQTF DVIEELGDGG YGFVCKVKHK IDDKIYAVKR
210 220 230 240 250
VEFNSEAEPE VKALARLDHP NIVRYFTCWP DSDNWMSNQE TNEKSNTTGS
260 270 280 290 300
STDTDDTNER SASDDDVADD EDDDDDDVSD DVTLGMESLT FTESTSAAKA
310 320 330 340 350
SGQCDPTNHR TYLFIQMEFC EGGTLTSWIG ERNYGGKQRI PLEIHRIFYE
360 370 380 390 400
ISSGVEYIHS NNLIHRDLKP DNILFNDGKV KIGDFGLVAA QKNPSGDPIE
410 420 430 440 450
RSKRKGTPTY MSPEQENLRN YDEKTDIFPL GLMWFEMLWK ISSGMERAEI
460 470 480 490 500
WTNLRNQKLP DQFCERYTAE NKFIEKMLSV TPEDRPHAKD IRLNLETFFS
510
LHQNSLSQKT I
Length:511
Mass (Da):58,539
Last modified:February 1, 2005 - v1
Checksum:i1E7E7695B63B9EEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929278 Genomic DNA. No translation available.
BC115215 mRNA. Translation: AAI15216.1.
BC131857 mRNA. Translation: AAI31858.1.
BC162488 mRNA. Translation: AAI62488.1.
AJ852019 mRNA. Translation: CAH68526.1.
RefSeqiNP_001035466.1. NM_001040376.2.
UniGeneiDr.18486.

Genome annotation databases

EnsembliENSDART00000038391; ENSDARP00000033668; ENSDARG00000052396.
GeneIDi503703.
KEGGidre:503703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929278 Genomic DNA. No translation available.
BC115215 mRNA. Translation: AAI15216.1 .
BC131857 mRNA. Translation: AAI31858.1 .
BC162488 mRNA. Translation: AAI62488.1 .
AJ852019 mRNA. Translation: CAH68526.1 .
RefSeqi NP_001035466.1. NM_001040376.2.
UniGenei Dr.18486.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4LB5 X-ray 2.00 A/B 5-70 [» ]
4LB6 X-ray 1.80 B 5-70 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000038391 ; ENSDARP00000033668 ; ENSDARG00000052396 .
GeneIDi 503703.
KEGGi dre:503703.

Organism-specific databases

CTDi 503703.
ZFINi ZDB-GENE-050301-2. pkz.

Phylogenomic databases

GeneTreei ENSGT00530000062984.
HOVERGENi HBG055855.
KOi K16195.
OMAi NEIEMRI.
OrthoDBi EOG71VSSK.
TreeFami TF317576.

Miscellaneous databases

NextBioi 20866259.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR000607. dsRNA_A_deaminase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 2 hits.
PF02295. z-alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains."
    Rothenburg S., Deigendesch N., Dittmar K., Koch-Nolte F., Haag F., Lowenhaupt K., Rich A.
    Proc. Natl. Acad. Sci. U.S.A. 102:1602-1607(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: WholeImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  4. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  6. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  7. "Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ."
    de Rosa M., Zacarias S., Athanasiadis A.
    Nucleic Acids Res. 41:9924-9933(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 5-70.

Entry informationi

Entry nameiQ5NE14_DANRE
AccessioniPrimary (citable) accession number: Q5NE14
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3