Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5NE14 (Q5NE14_DANRE) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Uncharacterized protein Ensembl ENSDARP00000033668

Z-DNA binding protein kinase EMBL CAH68526.1
Gene names
Name:pkz EMBL CAH68526.1 Ensembl ENSDARP00000033668 ZFIN ZDB-GENE-050301-2
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome] EMBL CAH68526.1
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region36 – 394Acetate 2 binding PDB 4LB5
Region61 – 622Acetate 3 binding PDB 4LB5

Sequences

Sequence LengthMass (Da)Tools
Q5NE14 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 1E7E7695B63B9EEB

FASTA51158,539
        10         20         30         40         50         60 
MAKMSAENEI EMRICDYLRR HGRSTVQDIF KELKLEKSTV NRHLYSLQAS KQVFKTVEDN 

        70         80         90        100        110        120 
KRPVWNLVES MNDEQKAKPE QIKPEMTRDA IEEKHVKDLL KSGGLKASHI ASKLGQQTQS 

       130        140        150        160        170        180 
TNKLLYGLME KGEVRKCSKS HMWTLKNDQE RNGSGSDRKL TSVSGMSQTF DVIEELGDGG 

       190        200        210        220        230        240 
YGFVCKVKHK IDDKIYAVKR VEFNSEAEPE VKALARLDHP NIVRYFTCWP DSDNWMSNQE 

       250        260        270        280        290        300 
TNEKSNTTGS STDTDDTNER SASDDDVADD EDDDDDDVSD DVTLGMESLT FTESTSAAKA 

       310        320        330        340        350        360 
SGQCDPTNHR TYLFIQMEFC EGGTLTSWIG ERNYGGKQRI PLEIHRIFYE ISSGVEYIHS 

       370        380        390        400        410        420 
NNLIHRDLKP DNILFNDGKV KIGDFGLVAA QKNPSGDPIE RSKRKGTPTY MSPEQENLRN 

       430        440        450        460        470        480 
YDEKTDIFPL GLMWFEMLWK ISSGMERAEI WTNLRNQKLP DQFCERYTAE NKFIEKMLSV 

       490        500        510 
TPEDRPHAKD IRLNLETFFS LHQNSLSQKT I 

« Hide

References

« Hide 'large scale' references
[1]"A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains."
Rothenburg S., Deigendesch N., Dittmar K., Koch-Nolte F., Haag F., Lowenhaupt K., Rich A.
Proc. Natl. Acad. Sci. U.S.A. 102:1602-1607(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Whole EMBL AAI15216.1.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney EMBL AAI31858.1.
[4]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Tuebingen Ensembl ENSDARP00000033668.
[6]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen Ensembl ENSDARP00000033668.
[7]"Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ."
de Rosa M., Zacarias S., Athanasiadis A.
Nucleic Acids Res. 41:9924-9933(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 5-70 IN COMPLEX WITH ACETATE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU929278 Genomic DNA. No translation available.
BC115215 mRNA. Translation: AAI15216.1.
BC131857 mRNA. Translation: AAI31858.1.
BC162488 mRNA. Translation: AAI62488.1.
AJ852019 mRNA. Translation: CAH68526.1.
RefSeqNP_001035466.1. NM_001040376.2.
UniGeneDr.18486.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4LB5X-ray2.00A/B5-70[»]
4LB6X-ray1.80B5-70[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000038391; ENSDARP00000033668; ENSDARG00000052396.
GeneID503703.
KEGGdre:503703.

Organism-specific databases

CTD503703.
ZFINZDB-GENE-050301-2. pkz.

Phylogenomic databases

GeneTreeENSGT00530000062984.
HOVERGENHBG055855.
InParanoidQ5NE14.
KOK16195.
OMANEIEMRI.
OrthoDBEOG71VSSK.
TreeFamTF317576.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
InterProIPR000607. dsRNA_A_deaminase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00069. Pkinase. 2 hits.
PF02295. z-alpha. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866259.

Entry information

Entry nameQ5NE14_DANRE
AccessionPrimary (citable) accession number: Q5NE14
Entry history
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: March 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)