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Q5NDL9

- EOGT_CANFA

UniProt

Q5NDL9 - EOGT_CANFA

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Protein
EGF domain-specific O-linked N-acetylglucosamine transferase
Gene
EOGT, AER61
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine.
UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

GO - Molecular functioni

  1. protein N-acetylglucosaminyltransferase activity Source: UniProtKB

GO - Biological processi

  1. protein O-linked glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT61. Glycosyltransferase Family 61.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF domain-specific O-linked N-acetylglucosamine transferase (EC:2.4.1.255)
Alternative name(s):
Extracellular O-linked N-acetylglucosamine transferase
Gene namesi
Name:EOGT
Synonyms:AER61
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 527510EGF domain-specific O-linked N-acetylglucosamine transferase
PRO_0000301971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000009819.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi295 – 2973Required for optimal activity By similarity
Motifi524 – 5274Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320328.
HOGENOMiHOG000033829.
HOVERGENiHBG056678.
InParanoidiQ5NDL9.
KOiK18134.
OrthoDBiEOG7D2FDQ.

Family and domain databases

InterProiIPR007657. Glycosyltransferase_AER61.
[Graphical view]
PfamiPF04577. DUF563. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NDL9-1 [UniParc]FASTAAdd to Basket

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MLKLLVLGVL LHDVSLSGQD EAPPKADGIP GEPLFNYASI RLPEEHIPFF    50
LHNNRHIATV CKKDSHCPYK KHLENLKYCW GYEKSCKPEF RFGYPVCTYI 100
DMGWTDTLES AQDIFWKQAD FGYAGERLEE LHVLCQPEEP HDSSLLCSRY 150
LQYCRAANLY LDLRNIKRNH DRFKEDFFQS GEIGGHCTLD TQTLLSEGQR 200
KSPLQSWFAE LQSYTELNFR PIEDAKCDVV IEKPTYFMKL DAGVNMYHHF 250
CDFVNLYITQ HVNNSFSTDV YIVMWDTSSY GYGDLFSDTW KAFTDYDVIH 300
LKTYDSKRVC FKEAVFSLLP RMRYGLFYNT PLISGCQNTG LFRAFSQHVL 350
HRLNITQEGP KDGKIRVTIL ARSTEYRKIL NQNELVNALK TVSTLEVQIV 400
DYKYKELGFL DQLRITHNTD IFIGMHGAGL THLLFLPDWA AVFELYNCED 450
ERCYLDLARL RGVHYITWRR QNKVFPQDKG HHPTLGEHPK FTNYSFDVEE 500
FMYLVLQAAD HVLQHPKWPF KKKRDEL 527
Length:527
Mass (Da):61,670
Last modified:February 1, 2005 - v1
Checksum:iDA5DE507862BB6AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ868227 mRNA. Translation: CAI30562.1.
RefSeqiNP_001009187.1. NM_001009187.1.
XP_005632096.1. XM_005632039.1.
XP_005632097.1. XM_005632040.1.
XP_005632098.1. XM_005632041.1.
UniGeneiCfa.16220.

Genome annotation databases

GeneIDi494221.
KEGGicfa:494221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ868227 mRNA. Translation: CAI30562.1 .
RefSeqi NP_001009187.1. NM_001009187.1.
XP_005632096.1. XM_005632039.1.
XP_005632097.1. XM_005632040.1.
XP_005632098.1. XM_005632041.1.
UniGenei Cfa.16220.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000009819.

Protein family/group databases

CAZyi GT61. Glycosyltransferase Family 61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 494221.
KEGGi cfa:494221.

Organism-specific databases

CTDi 285203.

Phylogenomic databases

eggNOGi NOG320328.
HOGENOMi HOG000033829.
HOVERGENi HBG056678.
InParanoidi Q5NDL9.
KOi K18134.
OrthoDBi EOG7D2FDQ.

Miscellaneous databases

NextBioi 20865674.

Family and domain databases

InterProi IPR007657. Glycosyltransferase_AER61.
[Graphical view ]
Pfami PF04577. DUF563. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of xylosyltransferases."
    Kiefer-Meyer M.C., Pagny S., Durambure G., Faye L., Gomord V., Mollicone R., Oriol R.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEOGT_CANFA
AccessioniPrimary (citable) accession number: Q5NDL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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