Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5NDL0

- EOGT_RAT

UniProt

Q5NDL0 - EOGT_RAT

Protein

EGF domain-specific O-linked N-acetylglucosamine transferase

Gene

Eogt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains By similarity.By similarity

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine.
    UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

    GO - Molecular functioni

    1. protein N-acetylglucosaminyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. protein O-linked glycosylation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT61. Glycosyltransferase Family 61.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF domain-specific O-linked N-acetylglucosamine transferase (EC:2.4.1.255)
    Alternative name(s):
    Extracellular O-linked N-acetylglucosamine transferase
    Gene namesi
    Name:Eogt
    Synonyms:Aer61
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1359357. Eogt.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 527508EGF domain-specific O-linked N-acetylglucosamine transferasePRO_0000301974Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5NDL0.

    PTM databases

    PhosphoSiteiQ5NDL0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5NDL0.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi295 – 2973Required for optimal activityBy similarity
    Motifi524 – 5274Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 61 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG320328.
    GeneTreeiENSGT00750000117715.
    HOGENOMiHOG000033829.
    HOVERGENiHBG056678.
    InParanoidiQ5NDL0.
    KOiK18134.
    OMAiDSKRVCF.
    OrthoDBiEOG7D2FDQ.
    PhylomeDBiQ5NDL0.
    TreeFamiTF313716.

    Family and domain databases

    InterProiIPR007657. Glycosyltransferase_AER61.
    [Graphical view]
    PfamiPF04577. DUF563. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NDL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMLLVFGVL LHEVPLSGQD EAHPEADRVP GEALYDYSSL RLPEEHIPFF    50
    LHSNRHVASV CREDSHCPYK KHLESLNSCW GYEKSCTPES RFGSPICSYV 100
    DLGWTDTLES AQDMFWKQAD FGYARERLEE IRMFCRPESA SDSSLLCSRY 150
    LQYCRATGLY LDLRNIKRNH DRFKEDFLQG GDIGGYCKLD RHALVSEGQR 200
    KSPLQSWFAE LQGYTQLNFR PIEDAKCDIV VEKPTYFMKL DAGINMYHHF 250
    CDFLNLYLTQ HINNSFSTDV YIVMWDTSSY GYGDLFSDTW KAFTDYDVIH 300
    LKTYDSKKVC FKEAVFSLLP RMRYGLFYNT PLISGCQNTG LFRAFSQHVL 350
    HRLNISQEGP KDGKLRVTIL ARSTEYRKIL NQNELVNALK TVSTFEVRVV 400
    DYKYRELGFL DQLRITHNTD IFIGMHGAGL THLLFLPDWA AVFELYNCED 450
    ERCYLDLARL RGIYYITWQK PSKVFPQDKG HHPTLGEHPK FTNYSFDVEE 500
    FMYLVLQAAE HVLQHPQWPL KKNHDEL 527
    Length:527
    Mass (Da):61,524
    Last modified:February 1, 2005 - v1
    Checksum:iCB8678AFF3B00870
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ868236 mRNA. Translation: CAI30571.1.
    RefSeqiNP_001009502.1. NM_001009502.1.
    UniGeneiRn.162760.

    Genome annotation databases

    EnsembliENSRNOT00000039353; ENSRNOP00000034561; ENSRNOG00000024533.
    GeneIDi494219.
    KEGGirno:494219.
    UCSCiRGD:1359357. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ868236 mRNA. Translation: CAI30571.1 .
    RefSeqi NP_001009502.1. NM_001009502.1.
    UniGenei Rn.162760.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT61. Glycosyltransferase Family 61.

    PTM databases

    PhosphoSitei Q5NDL0.

    Proteomic databases

    PaxDbi Q5NDL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000039353 ; ENSRNOP00000034561 ; ENSRNOG00000024533 .
    GeneIDi 494219.
    KEGGi rno:494219.
    UCSCi RGD:1359357. rat.

    Organism-specific databases

    CTDi 285203.
    RGDi 1359357. Eogt.

    Phylogenomic databases

    eggNOGi NOG320328.
    GeneTreei ENSGT00750000117715.
    HOGENOMi HOG000033829.
    HOVERGENi HBG056678.
    InParanoidi Q5NDL0.
    KOi K18134.
    OMAi DSKRVCF.
    OrthoDBi EOG7D2FDQ.
    PhylomeDBi Q5NDL0.
    TreeFami TF313716.

    Miscellaneous databases

    NextBioi 697310.
    PROi Q5NDL0.

    Gene expression databases

    Genevestigatori Q5NDL0.

    Family and domain databases

    InterProi IPR007657. Glycosyltransferase_AER61.
    [Graphical view ]
    Pfami PF04577. DUF563. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogeny of xylosyltransferases."
      Kiefer-Meyer M.C., Pagny S., Durambure G., Faye L., Gomord V., Mollicone R., Oriol R.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiEOGT_RAT
    AccessioniPrimary (citable) accession number: Q5NDL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3