Crk

Functionⁱ

GO - Molecular functionⁱ

cytoskeletal protein binding Source: Ensembl
ephrin receptor binding Source: Ensembl
insulin-like growth factor receptor binding Source: Ensembl
phosphotyrosine binding Source: Ensembl
protein self-association Source: Ensembl
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
SH2 domain binding Source: Ensembl
SH3/SH2 adaptor activity Source: Ensembl
SH3 domain binding Source: Ensembl

GO - Biological processⁱ

cellular response to endothelin Source: Ensembl
cellular response to insulin-like growth factor stimulus Source: Ensembl
cellular response to nerve growth factor stimulus Source: Ensembl
cellular response to nitric oxide Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
ephrin receptor signaling pathway Source: Ensembl
negative regulation of cell motility Source: Ensembl
negative regulation of natural killer cell mediated cytotoxicity Source: Ensembl
negative regulation of wound healing Source: Ensembl
positive regulation of smooth muscle cell migration Source: Ensembl
positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
regulation of actin cytoskeleton organization Source: Ensembl
regulation of cell shape Source: Ensembl
regulation of GTPase activity Source: Ensembl
regulation of protein binding Source: Ensembl
regulation of Rac protein signal transduction Source: Ensembl
response to cholecystokinin Source: Ensembl
response to hepatocyte growth factor Source: Ensembl
response to hydrogen peroxide Source: Ensembl
response to yeast Source: Ensembl
SH2 domain-mediated complex assembly Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported Submitted name: V-crk sarcoma virus CT10 oncogene homolog (Avian), isoform CRA_aImported Submitted name: V-crk sarcoma virus CT10 oncogene-like proteinImported
Gene namesⁱ	Name:CrkImported ORF Names:mCG_10785Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:88508. Crk.

Subcellular locationⁱ

GO - Cellular componentⁱ

actin cytoskeleton Source: Ensembl
extracellular exosome Source: Ensembl
membrane raft Source: Ensembl
protein complex Source: Ensembl

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000017776.
ExpressionAtlasⁱ	Q5ND51. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

cytoskeletal protein binding Source: Ensembl
ephrin receptor binding Source: Ensembl
insulin-like growth factor receptor binding Source: Ensembl
phosphotyrosine binding Source: Ensembl
protein self-association Source: Ensembl
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
SH2 domain binding Source: Ensembl
SH3/SH2 adaptor activity Source: Ensembl
SH3 domain binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q5ND51.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 118	SH2InterPro annotationAdd BLAST		106
Domainⁱ	132 – 192	SH3InterPro annotationAdd BLAST		61

Keywords - Domainⁱ

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG4792. Eukaryota. ENOG4110574. LUCA.
HOVERGENⁱ	HBG105616.
KEGG Orthology (KO) More...KOⁱ	K04438.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JPQ.

Family and domain databases

Gene3Dⁱ	3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit.
PRINTSⁱ	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMARTⁱ	View protein in SMART SM00252. SH2. 1 hit. SM00326. SH3. 2 hits.
SUPFAMⁱ	SSF50044. SSF50044. 3 hits. SSF55550. SSF55550. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50001. SH2. 1 hit. PS50002. SH3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5ND51-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS 
        60         70         80         90        100
VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL 
       110        120        130        140        150
LEFYKIHYLD TTTLIEPVAR SRQGSGVILR QEEAEYVRAL FDFNGNDEED 
       160        170        180        190        200
LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL 
       210        220        230        240        250
IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA RVIQKRVPNA 
       260        270        280        290        300
YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 

EDFS

Length:304

Mass (Da):33,815

Last modified:May 10, 2005 - v1

Checksum:ⁱ5491896FC7A89065

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902336 Genomic DNA. Translation: AAX90621.1. AK154987 mRNA. Translation: BAE32976.1. AK161761 mRNA. Translation: BAE36562.1. CH466596 Genomic DNA. Translation: EDL12834.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_598417.2. NM_133656.5.
UniGeneⁱ	Mm.280125.

Genome annotation databases

GeneIDⁱ	12928.
KEGGⁱ	mmu:12928.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902336 Genomic DNA. Translation: AAX90621.1. AK154987 mRNA. Translation: BAE32976.1. AK161761 mRNA. Translation: BAE36562.1. CH466596 Genomic DNA. Translation: EDL12834.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_598417.2. NM_133656.5.
UniGeneⁱ	Mm.280125.

3D structure databases

SMRⁱ	Q5ND51.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	12928.
KEGGⁱ	mmu:12928.

Organism-specific databases

CTDⁱ	1398.
MGIⁱ	MGI:88508. Crk.

Phylogenomic databases

eggNOGⁱ	KOG4792. Eukaryota. ENOG4110574. LUCA.
HOVERGENⁱ	HBG105616.
KEGG Orthology (KO) More...KOⁱ	K04438.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JPQ.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017776.
ExpressionAtlasⁱ	Q5ND51. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit.
PRINTSⁱ	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMARTⁱ	View protein in SMART SM00252. SH2. 1 hit. SM00326. SH3. 2 hits.
SUPFAMⁱ	SSF50044. SSF50044. 3 hits. SSF55550. SSF55550. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50001. SH2. 1 hit. PS50002. SH3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5ND51_MOUSE
Accessionⁱ	Q5ND51Primary (citable) accession number: Q5ND51
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	July 5, 2017
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q5ND51 (Q5ND51_MOUSE)

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Putative uncharacterized protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5ND51 (Q5ND51_MOUSE)

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Putative uncharacterized protein

Crk

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ