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Protein

Heat shock factor protein 5

Gene

Hsf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transcriptional factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi11 – 228By similarityAdd BLAST218

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor protein 5
Short name:
HSF 5
Alternative name(s):
Heat shock transcription factor 5
Short name:
HSTF 5
Protein expressed in male leptotene and zygotene spermatocytes 220
Short name:
MLZ-220
Gene namesi
Name:Hsf5
Synonyms:Gm739
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2685585. Hsf5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330421 – 624Heat shock factor protein 5Add BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei600PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5ND04.
PeptideAtlasiQ5ND04.
PRIDEiQ5ND04.

PTM databases

iPTMnetiQ5ND04.
PhosphoSitePlusiQ5ND04.

Expressioni

Tissue specificityi

Expressed in adult but not fetal testis. Not expressed in ovary.1 Publication

Gene expression databases

BgeeiENSMUSG00000070345.
GenevisibleiQ5ND04. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091488.

Structurei

3D structure databases

ProteinModelPortaliQ5ND04.
SMRiQ5ND04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 129Gly-richAdd BLAST74

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00510000048674.
HOGENOMiHOG000059263.
HOVERGENiHBG096755.
InParanoidiQ5ND04.
OMAiFHSPHFR.
OrthoDBiEOG091G07YE.
PhylomeDBiQ5ND04.
TreeFamiTF330401.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR027736. HSF5.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PTHR10015:SF138. PTHR10015:SF138. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5ND04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEALLSTPI NPNNFPAKLW RLVNSPRYRS IRWDGRGEGL LIDQPLFEAE
60 70 80 90 100
LLSPPGPGAG GAGGAGSSGG GGGSGVGAAG AEPELFKTTN FTSFIRQLNL
110 120 130 140 150
YGFRKVVLGG PGAAGPGPGP GAGGPAGDGP LHHFHSPHFR RDQPQLLVHL
160 170 180 190 200
KRLTSANKAK LAAGLEVPCR PPNRFQRLLI TSASASASAS TSPLQHQDPP
210 220 230 240 250
PQPAGPRPEQ HGPVAVGQFH RSFRRDNLSP YSYVSTSSHN HSAFPLKGLD
260 270 280 290 300
RTPIPPRTWQ NSLGMHPGQV ETSPTFSDKG VPFPVLQRFP TEVTYTLQPS
310 320 330 340 350
ATSVHVQQGP QTMVSSSQKY SNYTPSAQYS QAYYPTAVLQ CCSPPTHMDA
360 370 380 390 400
LSSCVTPTAS SYAHCNYFQN PPMQSSYPVE FLPSNWPCSA TDENKKTEVN
410 420 430 440 450
LEAVFQIVDE LHSSPKLEMV KVEPVETQCP SSQANRGQHI LPNANSSNPS
460 470 480 490 500
STSQASQLEP LTPVGSDITS FVVGTEQAIT CSLPQSPEYI YTIHTAQPLE
510 520 530 540 550
NSTMQESATI QQTHVKLKEQ LNHNPSPSSV VFVQEGLPFS TPQVDSSIKC
560 570 580 590 600
QTNPSENILP SEQMGFLISE MGPANKSTKD TGLSTPARYR ERRSNSQGKS
610 620
PDLHLLVDVA CKQEHFPKEE ELKE
Length:624
Mass (Da):67,316
Last modified:February 1, 2005 - v1
Checksum:i26E6C5406679104B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596086 Genomic DNA. Translation: CAI35140.1.
CU393486 Genomic DNA. Translation: CAQ52066.1.
AK166561 mRNA. Translation: BAE38854.1.
CCDSiCCDS36269.1.
RefSeqiNP_001038992.1. NM_001045527.1.
UniGeneiMm.390371.

Genome annotation databases

EnsembliENSMUST00000093956; ENSMUSP00000091488; ENSMUSG00000070345.
GeneIDi327992.
KEGGimmu:327992.
UCSCiuc007kuc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596086 Genomic DNA. Translation: CAI35140.1.
CU393486 Genomic DNA. Translation: CAQ52066.1.
AK166561 mRNA. Translation: BAE38854.1.
CCDSiCCDS36269.1.
RefSeqiNP_001038992.1. NM_001045527.1.
UniGeneiMm.390371.

3D structure databases

ProteinModelPortaliQ5ND04.
SMRiQ5ND04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091488.

PTM databases

iPTMnetiQ5ND04.
PhosphoSitePlusiQ5ND04.

Proteomic databases

PaxDbiQ5ND04.
PeptideAtlasiQ5ND04.
PRIDEiQ5ND04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093956; ENSMUSP00000091488; ENSMUSG00000070345.
GeneIDi327992.
KEGGimmu:327992.
UCSCiuc007kuc.1. mouse.

Organism-specific databases

CTDi124535.
MGIiMGI:2685585. Hsf5.

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00510000048674.
HOGENOMiHOG000059263.
HOVERGENiHBG096755.
InParanoidiQ5ND04.
OMAiFHSPHFR.
OrthoDBiEOG091G07YE.
PhylomeDBiQ5ND04.
TreeFamiTF330401.

Miscellaneous databases

PROiQ5ND04.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070345.
GenevisibleiQ5ND04. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR027736. HSF5.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PTHR10015:SF138. PTHR10015:SF138. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHSF5_MOUSE
AccessioniPrimary (citable) accession number: Q5ND04
Secondary accession number(s): B2KGG8, Q3TLD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.