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Protein

Up-regulator of cell proliferation

Gene

Urgcp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cell cycle progression through the regulation of cyclin D1 expression.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulator of cell proliferation
Alternative name(s):
HBV X protein up-regulated gene 4 protein homolog
HBxAg up-regulated gene 4 protein homolog
Gene namesi
Name:Urgcp
Synonyms:Urg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919296. Urgcp.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926Up-regulator of cell proliferationPRO_0000337149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5NCI0.
MaxQBiQ5NCI0.
PaxDbiQ5NCI0.
PeptideAtlasiQ5NCI0.
PRIDEiQ5NCI0.

PTM databases

iPTMnetiQ5NCI0.
PhosphoSiteiQ5NCI0.

Expressioni

Gene expression databases

BgeeiQ5NCI0.
ExpressionAtlasiQ5NCI0. baseline and differential.
GenevisibleiQ5NCI0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091053.

Structurei

3D structure databases

ProteinModelPortaliQ5NCI0.
SMRiQ5NCI0. Positions 692-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini689 – 924236VLIG-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IG57. Eukaryota.
ENOG410Y9GN. LUCA.
GeneTreeiENSGT00530000063016.
HOGENOMiHOG000154797.
HOVERGENiHBG108652.
InParanoidiQ5NCI0.
OMAiLAFCDPE.
OrthoDBiEOG7TQV06.
PhylomeDBiQ5NCI0.
TreeFamiTF335271.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030383. G_VLIG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51717. G_VLIG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q5NCI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPGIEVEL LVKGHSDLGE VAPEVKPSDS QTSVAIADLE WREMEGDDCG
60 70 80 90 100
FHYGDGTNEA QDNDFPTVER SRLQEMLSLL GLETYQAQKL TLQDSLQISF
110 120 130 140 150
DSMKNWAPQV PKDLPWHFLR KLQALNAEAR NTTMVLDVPP EAWPAEKESQ
160 170 180 190 200
AEEEMMYWDP AEDVAADIYS FSELPMPDTP VNPLDLLCAL LLSSDTFLQQ
210 220 230 240 250
EVLLKMSLCQ FALPLVLPDS ENHYHTFLLW ALRGVVRTWW FQPLRSLGSF
260 270 280 290 300
REDSVVLSRV PTFAFVRMDV SSNSKSQLLN AVLSPARRQW DCFWHRDLNL
310 320 330 340 350
GTNPREISDG LVEISWFFPS GKEDLDVFPE PMAFLNLRGD IGSHWLQFKL
360 370 380 390 400
LTEVSSAVFI LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF
410 420 430 440 450
LNRLIPVLKI DHSHVLVKVS STDSEGFVRR IRAIMCSVAR SPCRRVSVED
460 470 480 490 500
MAHAARKLGL RVDEDFEECQ KAKDRMEKIL RKIKDVDAYK RDELRLQGEP
510 520 530 540 550
ARRAAQAERE FCQLQWVPEP PEKHRAELRR RVLELRVQQN GQEPTSGVQE
560 570 580 590 600
FILGISSPSP SERQYFLRWM EWGLARLGQP RPRQPPETLL TLRPKLGGPS
610 620 630 640 650
DLTEPLWPEP LGVEHFLREM GQFYEAESCL IEAGRLPAGQ RRFAHFPGVA
660 670 680 690 700
VELLLGGLPL ELVDGATLSI PVRWVTGLLK ELHTRLDRRS RLVVLSALGV
710 720 730 740 750
PGTGKSTLLN TMFGLKFATG RSCSPRGAFM QLLPVAEGFS QDLGCDQILV
760 770 780 790 800
IDSGGLISGA LASAGDRFEL EASLATLLMG LSNVTVVSLA ETKDIPPAVL
810 820 830 840 850
HAFLRLEKMG HMPNYQFVYQ NLHDLPVPSP KPRDRRQLLD PPSDLSRATH
860 870 880 890 900
LEKQGGGFRT LAGLAERQHV WHIPALWHGA PPMAAVSLGY SEAIFELKRC
910 920
LLENIRNGLS NQNQNIQQLI ELLRRL
Length:926
Mass (Da):104,683
Last modified:February 1, 2005 - v1
Checksum:i34C1CC4AAC0D131C
GO
Isoform 21 Publication (identifier: Q5NCI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:883
Mass (Da):100,110
Checksum:i9D5B26E43BAB1588
GO

Sequence cautioni

The sequence AAH16589.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC28370.1 differs from that shown. Reason: Frameshift at position 804. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601A → T in BAE38807 (PubMed:16141072).Curated
Sequence conflicti291 – 2911D → Y in BAC29111 (PubMed:16141072).Curated
Sequence conflicti518 – 5181P → T in BAC29111 (PubMed:16141072).Curated
Sequence conflicti684 – 6841T → A in BAE38807 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 2. 1 PublicationVSP_052800Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033577 mRNA. Translation: BAC28370.1. Frameshift.
AK035580 mRNA. Translation: BAC29111.1.
AK041953 mRNA. Translation: BAC31109.1.
AK166495 mRNA. Translation: BAE38807.1.
AL627069 Genomic DNA. Translation: CAI25432.1.
AL627069 Genomic DNA. Translation: CAQ11138.1.
BC016589 mRNA. Translation: AAH16589.1. Sequence problems.
CCDSiCCDS36104.1. [Q5NCI0-1]
CCDS36105.1. [Q5NCI0-2]
RefSeqiNP_001071129.1. NM_001077661.1. [Q5NCI0-2]
NP_848738.2. NM_178623.3. [Q5NCI0-1]
XP_006514877.1. XM_006514814.2. [Q5NCI0-2]
XP_006514878.1. XM_006514815.2. [Q5NCI0-2]
XP_011242057.1. XM_011243755.1. [Q5NCI0-2]
XP_011242060.1. XM_011243758.1. [Q5NCI0-2]
UniGeneiMm.271657.

Genome annotation databases

EnsembliENSMUST00000053427; ENSMUSP00000055821; ENSMUSG00000049680. [Q5NCI0-2]
ENSMUST00000093362; ENSMUSP00000091053; ENSMUSG00000049680. [Q5NCI0-1]
ENSMUST00000118076; ENSMUSP00000113589; ENSMUSG00000049680. [Q5NCI0-2]
ENSMUST00000120306; ENSMUSP00000113060; ENSMUSG00000049680. [Q5NCI0-2]
ENSMUST00000170116; ENSMUSP00000133216; ENSMUSG00000049680. [Q5NCI0-2]
GeneIDi72046.
KEGGimmu:72046.
UCSCiuc007hwu.1. mouse. [Q5NCI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033577 mRNA. Translation: BAC28370.1. Frameshift.
AK035580 mRNA. Translation: BAC29111.1.
AK041953 mRNA. Translation: BAC31109.1.
AK166495 mRNA. Translation: BAE38807.1.
AL627069 Genomic DNA. Translation: CAI25432.1.
AL627069 Genomic DNA. Translation: CAQ11138.1.
BC016589 mRNA. Translation: AAH16589.1. Sequence problems.
CCDSiCCDS36104.1. [Q5NCI0-1]
CCDS36105.1. [Q5NCI0-2]
RefSeqiNP_001071129.1. NM_001077661.1. [Q5NCI0-2]
NP_848738.2. NM_178623.3. [Q5NCI0-1]
XP_006514877.1. XM_006514814.2. [Q5NCI0-2]
XP_006514878.1. XM_006514815.2. [Q5NCI0-2]
XP_011242057.1. XM_011243755.1. [Q5NCI0-2]
XP_011242060.1. XM_011243758.1. [Q5NCI0-2]
UniGeneiMm.271657.

3D structure databases

ProteinModelPortaliQ5NCI0.
SMRiQ5NCI0. Positions 692-759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091053.

PTM databases

iPTMnetiQ5NCI0.
PhosphoSiteiQ5NCI0.

Proteomic databases

EPDiQ5NCI0.
MaxQBiQ5NCI0.
PaxDbiQ5NCI0.
PeptideAtlasiQ5NCI0.
PRIDEiQ5NCI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053427; ENSMUSP00000055821; ENSMUSG00000049680. [Q5NCI0-2]
ENSMUST00000093362; ENSMUSP00000091053; ENSMUSG00000049680. [Q5NCI0-1]
ENSMUST00000118076; ENSMUSP00000113589; ENSMUSG00000049680. [Q5NCI0-2]
ENSMUST00000120306; ENSMUSP00000113060; ENSMUSG00000049680. [Q5NCI0-2]
ENSMUST00000170116; ENSMUSP00000133216; ENSMUSG00000049680. [Q5NCI0-2]
GeneIDi72046.
KEGGimmu:72046.
UCSCiuc007hwu.1. mouse. [Q5NCI0-1]

Organism-specific databases

CTDi55665.
MGIiMGI:1919296. Urgcp.

Phylogenomic databases

eggNOGiENOG410IG57. Eukaryota.
ENOG410Y9GN. LUCA.
GeneTreeiENSGT00530000063016.
HOGENOMiHOG000154797.
HOVERGENiHBG108652.
InParanoidiQ5NCI0.
OMAiLAFCDPE.
OrthoDBiEOG7TQV06.
PhylomeDBiQ5NCI0.
TreeFamiTF335271.

Miscellaneous databases

ChiTaRSiUrgcp. mouse.
PROiQ5NCI0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5NCI0.
ExpressionAtlasiQ5NCI0. baseline and differential.
GenevisibleiQ5NCI0. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030383. G_VLIG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51717. G_VLIG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6JImported.
    Tissue: CecumImported, Mammary glandImported, ThymusImported and Urinary bladderImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 518-816 (ISOFORMS 1/2).
    Tissue: Mammary tumorImported.

Entry informationi

Entry nameiURGCP_MOUSE
AccessioniPrimary (citable) accession number: Q5NCI0
Secondary accession number(s): A0PJ66
, Q3TLI5, Q8C9K3, Q8CBP7, Q8CC98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 1, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.