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Protein

F-box only protein 39

Gene

Fbxo39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 39
Gene namesi
Name:Fbxo39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3505735. Fbxo39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199361 – 443F-box only protein 39Add BLAST443

Proteomic databases

PaxDbiQ5NBU5.
PRIDEiQ5NBU5.

PTM databases

PhosphoSitePlusiQ5NBU5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000070388.
CleanExiMM_FBXO39.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104144.

Structurei

3D structure databases

ProteinModelPortaliQ5NBU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 59F-boxPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IT1X. Eukaryota.
ENOG4111FS0. LUCA.
GeneTreeiENSGT00510000048837.
HOGENOMiHOG000112546.
HOVERGENiHBG051580.
InParanoidiQ5NBU5.
KOiK10314.
OMAiEGQCALR.
OrthoDBiEOG091G0NJN.
PhylomeDBiQ5NBU5.
TreeFamiTF321665.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5NBU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDCEVTQL QEQSCWATLP DVCLRRVFWW LGDRDRSRAA LVCRKWNQIM
60 70 80 90 100
YSADLWRYRT ITFSGRPSRV HASEFESALW YIKKFGRYLE HLEIKFLNPY
110 120 130 140 150
NAVLTKKFQV TMRGLLSCLG KSNNRLRSLS IQHLELDRLV WRNSIRGSLI
160 170 180 190 200
KSLSFFLKKM GKHLDHLSLK GARLTVEQGC HILNSLSYMQ NENMASELNI
210 220 230 240 250
EDFFSHHLAV YGSSQFNKAM ATFRNLTFLT LNYNCISDEL LETLSENNAG
260 270 280 290 300
TLRTMNIKCH VHDPHGQVVW GMSWAKLARQ ASNLKVNFFF ERVMKYERLA
310 320 330 340 350
RILLQEIPVR SISLRSCYFS DPDWSMRPTL TDLLPTFRNT LQKLTFEFNN
360 370 380 390 400
NHESLDEQLH LLILACRKLF YFKIWAFLDV KFVERILKSQ EEGQCSLHTL
410 420 430 440
KVRIYTNRYE TNEEDRTLRE IYRKYRKLID SELNYFVVAY PMM
Length:443
Mass (Da):52,554
Last modified:March 15, 2005 - v2
Checksum:i4F7D3B5F8B579213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929071 Genomic DNA. Translation: CAI36035.2.
CCDSiCCDS36214.1.
RefSeqiNP_001093158.1. NM_001099688.2.
XP_006533965.2. XM_006533902.3.
UniGeneiMm.390365.

Genome annotation databases

EnsembliENSMUST00000108504; ENSMUSP00000104144; ENSMUSG00000070388.
GeneIDi628100.
KEGGimmu:628100.
UCSCiuc007jys.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929071 Genomic DNA. Translation: CAI36035.2.
CCDSiCCDS36214.1.
RefSeqiNP_001093158.1. NM_001099688.2.
XP_006533965.2. XM_006533902.3.
UniGeneiMm.390365.

3D structure databases

ProteinModelPortaliQ5NBU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104144.

PTM databases

PhosphoSitePlusiQ5NBU5.

Proteomic databases

PaxDbiQ5NBU5.
PRIDEiQ5NBU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108504; ENSMUSP00000104144; ENSMUSG00000070388.
GeneIDi628100.
KEGGimmu:628100.
UCSCiuc007jys.2. mouse.

Organism-specific databases

CTDi162517.
MGIiMGI:3505735. Fbxo39.

Phylogenomic databases

eggNOGiENOG410IT1X. Eukaryota.
ENOG4111FS0. LUCA.
GeneTreeiENSGT00510000048837.
HOGENOMiHOG000112546.
HOVERGENiHBG051580.
InParanoidiQ5NBU5.
KOiK10314.
OMAiEGQCALR.
OrthoDBiEOG091G0NJN.
PhylomeDBiQ5NBU5.
TreeFamiTF321665.

Miscellaneous databases

PROiQ5NBU5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070388.
CleanExiMM_FBXO39.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX39_MOUSE
AccessioniPrimary (citable) accession number: Q5NBU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.