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Protein

Histidinol dehydrogenase, chloroplastic

Gene

HDH

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathway: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase, chloroplastic (Os03g0134300)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Imidazoleglycerol-phosphate dehydratase (OSJNBa0093O08.11), Imidazoleglycerol-phosphate dehydratase, Imidazoleglycerol-phosphate dehydratase
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase, chloroplastic (Os01g0232700), Histidinol dehydrogenase, chloroplastic (HDH)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei162 – 1621NADBy similarity
Binding sitei224 – 2241NADBy similarity
Binding sitei247 – 2471NADBy similarity
Binding sitei273 – 2731SubstrateBy similarity
Metal bindingi295 – 2951ZincBy similarity
Binding sitei295 – 2951SubstrateBy similarity
Metal bindingi298 – 2981ZincBy similarity
Binding sitei298 – 2981SubstrateBy similarity
Active sitei363 – 3631Proton acceptorBy similarity
Active sitei364 – 3641Proton acceptorBy similarity
Binding sitei364 – 3641SubstrateBy similarity
Metal bindingi397 – 3971ZincBy similarity
Binding sitei397 – 3971SubstrateBy similarity
Binding sitei451 – 4511SubstrateBy similarity
Metal bindingi456 – 4561ZincBy similarity
Binding sitei456 – 4561SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase, chloroplastic (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:HDH
Ordered Locus Names:Os01g0232700, LOC_Os01g13190
ORF Names:P0702F03.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
ProteomesiUP000000763 Componenti: Chromosome 1

Organism-specific databases

GrameneiQ5NAY4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 473Histidinol dehydrogenase, chloroplasticPRO_0000247479
Transit peptidei1 – ?Chloroplast

Expressioni

Gene expression databases

ExpressionAtlasiQ5NAY4. baseline.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g13190.1.

Structurei

3D structure databases

ProteinModelPortaliQ5NAY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ5NAY4.
KOiK00013.
OMAiLSVQSFL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NAY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRPGRAHP LAASPLHTPL PARPRPQLRL STSTSCAAMK SYRLSELSDA
60 70 80 90 100
EVGGLKARPR IDFSSIFGTV NPIVEDVRMR GDAAVKDYTV KFDKVALDDV
110 120 130 140 150
VVRVSDLPDV ELDPAVKEAF DVAYDNIYAF HVSQKLPEKT VENMKGVRCK
160 170 180 190 200
RITRCIGSVG LYVPGGTAVL PSTALMLAVP AQIAGCKTVV LATPPSRDGS
210 220 230 240 250
ICKEVLYCAK KAGVTHVLKA GGAQAISAMA WGTVSCPKVE KIFGPGNQYV
260 270 280 290 300
TAAKMILQNS EAMVSIDMPA GPSEVLVIAD KYANPVHVAA DLLSQAEHGP
310 320 330 340 350
DSQVVLVVAG DGVDLGAIEA EVSKQCSALP RGEFASKALG HSFTVFAKDM
360 370 380 390 400
VEAISFSNMY APEHLIINVK DAEQWEDLVE NAGSVFLGQW TPESVGDYAS
410 420 430 440 450
GTNHVLPTYG YARMYSGVSL NSFLKYITVQ SLSEEGLRSL GPHVAKMAEV
460 470
EGLEAHRRAV TLRLQDIEAT VTV
Length:473
Mass (Da):50,566
Last modified:February 1, 2005 - v1
Checksum:iE46A7D59CEC1B412
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002481 Genomic DNA. Translation: BAD81372.1.
AK069972 mRNA. No translation available.
RefSeqiNP_001042506.1. NM_001049041.1.
UniGeneiOs.27540.

Genome annotation databases

EnsemblPlantsiOS01T0232700-01; OS01T0232700-01; OS01G0232700.
GeneIDi4324282.
KEGGiosa:4324282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002481 Genomic DNA. Translation: BAD81372.1.
AK069972 mRNA. No translation available.
RefSeqiNP_001042506.1. NM_001049041.1.
UniGeneiOs.27540.

3D structure databases

ProteinModelPortaliQ5NAY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os01g13190.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS01T0232700-01; OS01T0232700-01; OS01G0232700.
GeneIDi4324282.
KEGGiosa:4324282.

Organism-specific databases

GrameneiQ5NAY4.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ5NAY4.
KOiK00013.
OMAiLSVQSFL.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Gene expression databases

ExpressionAtlasiQ5NAY4. baseline.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHISX_ORYSJ
AccessioniPrimary (citable) accession number: Q5NAY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 1, 2005
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.