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Q5NAY4

- HISX_ORYSJ

UniProt

Q5NAY4 - HISX_ORYSJ

Protein

Histidinol dehydrogenase, chloroplastic

Gene

HDH

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei162 – 1621NADBy similarity
    Binding sitei224 – 2241NADBy similarity
    Binding sitei247 – 2471NADBy similarity
    Binding sitei273 – 2731SubstrateBy similarity
    Metal bindingi295 – 2951ZincBy similarity
    Binding sitei295 – 2951SubstrateBy similarity
    Metal bindingi298 – 2981ZincBy similarity
    Binding sitei298 – 2981SubstrateBy similarity
    Active sitei363 – 3631Proton acceptorBy similarity
    Active sitei364 – 3641Proton acceptorBy similarity
    Binding sitei364 – 3641SubstrateBy similarity
    Metal bindingi397 – 3971ZincBy similarity
    Binding sitei397 – 3971SubstrateBy similarity
    Binding sitei451 – 4511SubstrateBy similarity
    Metal bindingi456 – 4561ZincBy similarity
    Binding sitei456 – 4561SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway
    2. pollen development Source: EnsemblPlants/Gramene
    3. response to UV Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase, chloroplastic (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:HDH
    Ordered Locus Names:Os01g0232700, LOC_Os01g13190
    ORF Names:P0702F03.3
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 1

    Organism-specific databases

    GrameneiQ5NAY4.

    Subcellular locationi

    Plastidchloroplast By similarity

    GO - Cellular componenti

    1. chloroplast stroma Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 473Histidinol dehydrogenase, chloroplasticPRO_0000247479
    Transit peptidei1 – ?Chloroplast

    Structurei

    3D structure databases

    ProteinModelPortaliQ5NAY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiERISSFH.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5NAY4-1 [UniParc]FASTAAdd to Basket

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    MSLRPGRAHP LAASPLHTPL PARPRPQLRL STSTSCAAMK SYRLSELSDA    50
    EVGGLKARPR IDFSSIFGTV NPIVEDVRMR GDAAVKDYTV KFDKVALDDV 100
    VVRVSDLPDV ELDPAVKEAF DVAYDNIYAF HVSQKLPEKT VENMKGVRCK 150
    RITRCIGSVG LYVPGGTAVL PSTALMLAVP AQIAGCKTVV LATPPSRDGS 200
    ICKEVLYCAK KAGVTHVLKA GGAQAISAMA WGTVSCPKVE KIFGPGNQYV 250
    TAAKMILQNS EAMVSIDMPA GPSEVLVIAD KYANPVHVAA DLLSQAEHGP 300
    DSQVVLVVAG DGVDLGAIEA EVSKQCSALP RGEFASKALG HSFTVFAKDM 350
    VEAISFSNMY APEHLIINVK DAEQWEDLVE NAGSVFLGQW TPESVGDYAS 400
    GTNHVLPTYG YARMYSGVSL NSFLKYITVQ SLSEEGLRSL GPHVAKMAEV 450
    EGLEAHRRAV TLRLQDIEAT VTV 473
    Length:473
    Mass (Da):50,566
    Last modified:February 1, 2005 - v1
    Checksum:iE46A7D59CEC1B412
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002481 Genomic DNA. Translation: BAD81372.1.
    AK069972 mRNA. No translation available.
    RefSeqiNP_001042506.1. NM_001049041.1.
    UniGeneiOs.27540.

    Genome annotation databases

    EnsemblPlantsiOS01T0232700-01; OS01T0232700-01; OS01G0232700.
    GeneIDi4324282.
    KEGGiosa:4324282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002481 Genomic DNA. Translation: BAD81372.1 .
    AK069972 mRNA. No translation available.
    RefSeqi NP_001042506.1. NM_001049041.1.
    UniGenei Os.27540.

    3D structure databases

    ProteinModelPortali Q5NAY4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS01T0232700-01 ; OS01T0232700-01 ; OS01G0232700 .
    GeneIDi 4324282.
    KEGGi osa:4324282.

    Organism-specific databases

    Gramenei Q5NAY4.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi ERISSFH.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence and structure of rice chromosome 1."
      Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
      , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
      Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiHISX_ORYSJ
    AccessioniPrimary (citable) accession number: Q5NAY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3