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Q5NAY4

- HISX_ORYSJ

UniProt

Q5NAY4 - HISX_ORYSJ

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Protein

Histidinol dehydrogenase, chloroplastic

Gene

HDH

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei162 – 1621NADBy similarity
Binding sitei224 – 2241NADBy similarity
Binding sitei247 – 2471NADBy similarity
Binding sitei273 – 2731SubstrateBy similarity
Metal bindingi295 – 2951ZincBy similarity
Binding sitei295 – 2951SubstrateBy similarity
Metal bindingi298 – 2981ZincBy similarity
Binding sitei298 – 2981SubstrateBy similarity
Active sitei363 – 3631Proton acceptorBy similarity
Active sitei364 – 3641Proton acceptorBy similarity
Binding sitei364 – 3641SubstrateBy similarity
Metal bindingi397 – 3971ZincBy similarity
Binding sitei397 – 3971SubstrateBy similarity
Binding sitei451 – 4511SubstrateBy similarity
Metal bindingi456 – 4561ZincBy similarity
Binding sitei456 – 4561SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: EnsemblPlants/Gramene
  3. zinc ion binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
  2. pollen development Source: EnsemblPlants/Gramene
  3. spermidine biosynthetic process Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase, chloroplastic (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:HDH
Ordered Locus Names:Os01g0232700, LOC_Os01g13190
ORF Names:P0702F03.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ5NAY4.

Subcellular locationi

Plastidchloroplast By similarity

GO - Cellular componenti

  1. chloroplast stroma Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 473Histidinol dehydrogenase, chloroplasticPRO_0000247479
Transit peptidei1 – ?Chloroplast

Expressioni

Gene expression databases

ExpressionAtlasiQ5NAY4. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ5NAY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ5NAY4.
KOiK00013.
OMAiERISSFH.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NAY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLRPGRAHP LAASPLHTPL PARPRPQLRL STSTSCAAMK SYRLSELSDA
60 70 80 90 100
EVGGLKARPR IDFSSIFGTV NPIVEDVRMR GDAAVKDYTV KFDKVALDDV
110 120 130 140 150
VVRVSDLPDV ELDPAVKEAF DVAYDNIYAF HVSQKLPEKT VENMKGVRCK
160 170 180 190 200
RITRCIGSVG LYVPGGTAVL PSTALMLAVP AQIAGCKTVV LATPPSRDGS
210 220 230 240 250
ICKEVLYCAK KAGVTHVLKA GGAQAISAMA WGTVSCPKVE KIFGPGNQYV
260 270 280 290 300
TAAKMILQNS EAMVSIDMPA GPSEVLVIAD KYANPVHVAA DLLSQAEHGP
310 320 330 340 350
DSQVVLVVAG DGVDLGAIEA EVSKQCSALP RGEFASKALG HSFTVFAKDM
360 370 380 390 400
VEAISFSNMY APEHLIINVK DAEQWEDLVE NAGSVFLGQW TPESVGDYAS
410 420 430 440 450
GTNHVLPTYG YARMYSGVSL NSFLKYITVQ SLSEEGLRSL GPHVAKMAEV
460 470
EGLEAHRRAV TLRLQDIEAT VTV
Length:473
Mass (Da):50,566
Last modified:February 1, 2005 - v1
Checksum:iE46A7D59CEC1B412
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002481 Genomic DNA. Translation: BAD81372.1.
AK069972 mRNA. No translation available.
RefSeqiNP_001042506.1. NM_001049041.1.
UniGeneiOs.27540.

Genome annotation databases

EnsemblPlantsiOS01T0232700-01; OS01T0232700-01; OS01G0232700.
GeneIDi4324282.
KEGGiosa:4324282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002481 Genomic DNA. Translation: BAD81372.1 .
AK069972 mRNA. No translation available.
RefSeqi NP_001042506.1. NM_001049041.1.
UniGenei Os.27540.

3D structure databases

ProteinModelPortali Q5NAY4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0232700-01 ; OS01T0232700-01 ; OS01G0232700 .
GeneIDi 4324282.
KEGGi osa:4324282.

Organism-specific databases

Gramenei Q5NAY4.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
InParanoidi Q5NAY4.
KOi K00013.
OMAi ERISSFH.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Gene expression databases

ExpressionAtlasi Q5NAY4. baseline.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHISX_ORYSJ
AccessioniPrimary (citable) accession number: Q5NAY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3