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Q5NAY4

- HISX_ORYSJ

UniProt

Q5NAY4 - HISX_ORYSJ

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Protein
Histidinol dehydrogenase, chloroplastic
Gene
HDH, Os01g0232700, LOC_Os01g13190, P0702F03.3
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei162 – 1621NAD By similarity
Binding sitei224 – 2241NAD By similarity
Binding sitei247 – 2471NAD By similarity
Binding sitei273 – 2731Substrate By similarity
Metal bindingi295 – 2951Zinc By similarity
Binding sitei295 – 2951Substrate By similarity
Metal bindingi298 – 2981Zinc By similarity
Binding sitei298 – 2981Substrate By similarity
Active sitei363 – 3631Proton acceptor By similarity
Active sitei364 – 3641Proton acceptor By similarity
Binding sitei364 – 3641Substrate By similarity
Metal bindingi397 – 3971Zinc By similarity
Binding sitei397 – 3971Substrate By similarity
Binding sitei451 – 4511Substrate By similarity
Metal bindingi456 – 4561Zinc By similarity
Binding sitei456 – 4561Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
  2. pollen development Source: EnsemblPlants/Gramene
  3. response to UV Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase, chloroplastic (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:HDH
Ordered Locus Names:Os01g0232700, LOC_Os01g13190
ORF Names:P0702F03.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ5NAY4.

Subcellular locationi

Plastidchloroplast By similarity UniRule annotation

GO - Cellular componenti

  1. chloroplast stroma Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 473Histidinol dehydrogenase, chloroplasticUniRule annotationPRO_0000247479
Transit peptidei1 – ?ChloroplastUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5NAY4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiERISSFH.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5NAY4-1 [UniParc]FASTAAdd to Basket

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MSLRPGRAHP LAASPLHTPL PARPRPQLRL STSTSCAAMK SYRLSELSDA    50
EVGGLKARPR IDFSSIFGTV NPIVEDVRMR GDAAVKDYTV KFDKVALDDV 100
VVRVSDLPDV ELDPAVKEAF DVAYDNIYAF HVSQKLPEKT VENMKGVRCK 150
RITRCIGSVG LYVPGGTAVL PSTALMLAVP AQIAGCKTVV LATPPSRDGS 200
ICKEVLYCAK KAGVTHVLKA GGAQAISAMA WGTVSCPKVE KIFGPGNQYV 250
TAAKMILQNS EAMVSIDMPA GPSEVLVIAD KYANPVHVAA DLLSQAEHGP 300
DSQVVLVVAG DGVDLGAIEA EVSKQCSALP RGEFASKALG HSFTVFAKDM 350
VEAISFSNMY APEHLIINVK DAEQWEDLVE NAGSVFLGQW TPESVGDYAS 400
GTNHVLPTYG YARMYSGVSL NSFLKYITVQ SLSEEGLRSL GPHVAKMAEV 450
EGLEAHRRAV TLRLQDIEAT VTV 473
Length:473
Mass (Da):50,566
Last modified:February 1, 2005 - v1
Checksum:iE46A7D59CEC1B412
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002481 Genomic DNA. Translation: BAD81372.1.
AK069972 mRNA. No translation available.
RefSeqiNP_001042506.1. NM_001049041.1.
UniGeneiOs.27540.

Genome annotation databases

EnsemblPlantsiOS01T0232700-01; OS01T0232700-01; OS01G0232700.
GeneIDi4324282.
KEGGiosa:4324282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002481 Genomic DNA. Translation: BAD81372.1 .
AK069972 mRNA. No translation available.
RefSeqi NP_001042506.1. NM_001049041.1.
UniGenei Os.27540.

3D structure databases

ProteinModelPortali Q5NAY4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0232700-01 ; OS01T0232700-01 ; OS01G0232700 .
GeneIDi 4324282.
KEGGi osa:4324282.

Organism-specific databases

Gramenei Q5NAY4.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi ERISSFH.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHISX_ORYSJ
AccessioniPrimary (citable) accession number: Q5NAY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi