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Q5NAY4 (HISX_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase, chloroplastic

Short name=HDH
EC=1.1.1.23
Gene names
Name:HDH
Ordered Locus Names:Os01g0232700, LOC_Os01g13190
ORF Names:P0702F03.3
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Subcellular location

Plastidchloroplast By similarity HAMAP-Rule MF_01024.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

pollen development

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to UV

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentchloroplast stroma

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Chloroplast HAMAP-Rule MF_01024
Chain? – 473Histidinol dehydrogenase, chloroplastic HAMAP-Rule MF_01024PRO_0000247479

Sites

Active site3631Proton acceptor By similarity
Active site3641Proton acceptor By similarity
Metal binding2951Zinc By similarity
Metal binding2981Zinc By similarity
Metal binding3971Zinc By similarity
Metal binding4561Zinc By similarity
Binding site1621NAD By similarity
Binding site2241NAD By similarity
Binding site2471NAD By similarity
Binding site2731Substrate By similarity
Binding site2951Substrate By similarity
Binding site2981Substrate By similarity
Binding site3641Substrate By similarity
Binding site3971Substrate By similarity
Binding site4511Substrate By similarity
Binding site4561Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5NAY4 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: E46A7D59CEC1B412

FASTA47350,566
        10         20         30         40         50         60 
MSLRPGRAHP LAASPLHTPL PARPRPQLRL STSTSCAAMK SYRLSELSDA EVGGLKARPR 

        70         80         90        100        110        120 
IDFSSIFGTV NPIVEDVRMR GDAAVKDYTV KFDKVALDDV VVRVSDLPDV ELDPAVKEAF 

       130        140        150        160        170        180 
DVAYDNIYAF HVSQKLPEKT VENMKGVRCK RITRCIGSVG LYVPGGTAVL PSTALMLAVP 

       190        200        210        220        230        240 
AQIAGCKTVV LATPPSRDGS ICKEVLYCAK KAGVTHVLKA GGAQAISAMA WGTVSCPKVE 

       250        260        270        280        290        300 
KIFGPGNQYV TAAKMILQNS EAMVSIDMPA GPSEVLVIAD KYANPVHVAA DLLSQAEHGP 

       310        320        330        340        350        360 
DSQVVLVVAG DGVDLGAIEA EVSKQCSALP RGEFASKALG HSFTVFAKDM VEAISFSNMY 

       370        380        390        400        410        420 
APEHLIINVK DAEQWEDLVE NAGSVFLGQW TPESVGDYAS GTNHVLPTYG YARMYSGVSL 

       430        440        450        460        470 
NSFLKYITVQ SLSEEGLRSL GPHVAKMAEV EGLEAHRRAV TLRLQDIEAT VTV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP002481 Genomic DNA. Translation: BAD81372.1.
AK069972 mRNA. No translation available.
RefSeqNP_001042506.1. NM_001049041.1.
UniGeneOs.27540.

3D structure databases

ProteinModelPortalQ5NAY4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS01T0232700-01; OS01T0232700-01; OS01G0232700.
GeneID4324282.
KEGGosa:4324282.

Organism-specific databases

GrameneQ5NAY4.

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
ProtClustDBPLN02926.

Enzyme and pathway databases

UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_ORYSJ
AccessionPrimary (citable) accession number: Q5NAY4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways